Nature Microbiology, Год журнала: 2023, Номер 8(6), С. 1095 - 1107
Опубликована: Май 15, 2023
Язык: Английский
Nature Immunology, Год журнала: 2023, Номер 24(10), С. 1616 - 1627
Опубликована: Сен. 4, 2023
Язык: Английский
Процитировано
195
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(6), С. 321 - 344
Опубликована: Апрель 19, 2023
Acute COVID-19 infection is followed by prolonged symptoms in approximately one ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host (chronic inflammation, metabolic endocrine dysregulation, immune autoimmunity); downstream impacts (tissue damage from the initial infection, tissue hypoxia, dysbiosis, autonomic nervous system dysfunction). These mechanisms culminate long-term persistence disorder characterized a thrombotic endothelialitis, endothelial hyperactivated platelets, fibrinaloid microclots. abnormalities blood vessels coagulation affect every organ represent unifying pathway for various
Язык: Английский
Процитировано
153
Journal of Medical Virology, Год журнала: 2023, Номер 95(2)
Опубликована: Фев. 1, 2023
ABSTRACT SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in death millions worldwide since beginning pandemic December 2019. While much progress been made to understand acute manifestations SARS‐CoV‐2 infection, less is known about post‐acute sequelae (PASC). We investigated levels both Spike protein (Spike) and viral RNA circulating patients hospitalized with without PASC. found that were more likely be present Among these patients, 30% positive for RNA; whereas, none individuals PASC both. The and/or PASC+ve increased or remained same as phase; PASC−ve group, components decreased totally absent. Additionally, this first report show part linked extracellular vesicles any presence vesicles. In conclusion, our findings suggest fragments persist recovered up 1 year longer after infection.
Язык: Английский
Процитировано
90
Viruses, Год журнала: 2023, Номер 15(2), С. 400 - 400
Опубликована: Янв. 31, 2023
A novel syndrome called long-haul COVID or long is increasingly recognized in a significant percentage of individuals within few months after infection with SARS-CoV-2. This disorder characterized by wide range persisting, returning even new but related symptoms that involve different tissues and organs, including respiratory, cardiac, vascular, gastrointestinal, musculo-skeletal, neurological, endocrine systemic. Some overlapping symptomatologies exist between myalgic encephalomyelitis/chronic fatigue (ME/CFS). Very much like ME/CFS, infections herpes family viruses, immune dysregulation, the persistence inflammation have been reported as most common pattern for development COVID. review describes several factors determinants proposed, elaborating mainly on viral persistence, reactivation latent viruses such Epstein–Barr virus human herpesvirus 6 which are also associated pathology superantigen activation system, disturbance gut microbiome, multiple tissue damage autoimmunity. Based these factors, we propose diagnostic strategies measurement IgG IgM antibodies against SARS-CoV-2, EBV, HHV-6, superantigens, microbiota, biomarkers autoimmunity to better understand manage this multi-factorial continues affect millions people world.
Язык: Английский
Процитировано
84
Cell, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
42
Frontiers in Molecular Biosciences, Год журнала: 2023, Номер 10
Опубликована: Апрель 26, 2023
The emergence of persistent ill-health in the aftermath SARS-CoV-2 infection has presented significant challenges to patients, healthcare workers and researchers. Termed long COVID, or post-acute sequelae COVID-19 (PASC), symptoms this condition are highly variable span multiple body systems. underlying pathophysiology remains poorly understood, with no therapeutic agents proven be effective. This narrative review describes predominant clinical features phenotypes COVID alongside data supporting potential pathogenesis these including ongoing immune dysregulation, viral persistence, endotheliopathy, gastrointestinal microbiome disturbance, autoimmunity, dysautonomia. Finally, we describe current therapies under investigation, as well future options based on proposed research.
Язык: Английский
Процитировано
37
The Lancet Microbe, Год журнала: 2023, Номер 4(9), С. e745 - e756
Опубликована: Июнь 26, 2023
In this Personal View, we discuss current knowledge on SARS-CoV-2 RNA or antigen persistence in children infected with SARS-CoV-2. Based the evidence that virus can persist adults, have done a literature review and analysed studies looked for antigens undergoing autopsy, biopsy, surgery either death from COVID-19 multisystem inflammatory syndrome, assessments long other conditions. Our analysis suggests children, independent disease severity, spread systemically weeks to months. We what is known about biological effects of viral infections highlight new scenarios clinical, pharmacological, basic research exploration. Such an approach will improve understanding management post-viral syndromes.
Язык: Английский
Процитировано
33
Cell Reports Medicine, Год журнала: 2024, Номер 5(2), С. 101392 - 101392
Опубликована: Янв. 26, 2024
Lassa fever (LF) is an acute viral illness that causes thousands of deaths annually in West Africa. There are currently no virus (LASV) vaccines or antivirals approved for human use. Recently, we showed combinations broadly neutralizing monoclonal antibodies (BNhuMAbs) known as Arevirumab-2 Arevirumab-3 protected up to 100% cynomolgus macaques against challenge with diverse lineages LASV when treatment was initiated at advanced stages disease. This previous work assessed efficacy parenteral exposure. However, transmission humans occurs primarily by mucosal exposure shed from Mastomys rodents. Here, describe the development a lethal intranasal macaque model LF. employed show Arevirumab cocktails rescue infection 8 days after Our demonstrates BNhuMAbs have utility treating acquired through
Язык: Английский
Процитировано
10
Infection, Год журнала: 2024, Номер 52(5), С. 2043 - 2059
Опубликована: Май 27, 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of highly contagious disease Corona Virus Disease 2019 (COVID-19) that may lead to various neurological and psychological disorders can be acute, lasting days weeks or months possibly longer. latter known as long-COVID more recently post-acute sequelae COVID (PASC). During COVID-19 infection, a strong inflammatory response, cytokine storm, occurs in some patients. levels interferon-γ (IFN-γ), interferon-β (IFN-β), interleukin-6 (IL-6) tumour necrosis factor-alpha (TNF-α) are particularly increased. These cytokines activate enzyme indoleamine 2,3-dioxygenase 1 (IDO-1), catalysing first step tryptophan (Trp) catabolism through kynurenine pathway (KP) leading production several neurotoxic immunosuppressive metabolites. There already data showing elevation KP metabolites both acutely PASC, especially regarding cognitive impairment. Thus, it likely involvement significant SARS-CoV-2 pathogenesis neurologically.
Язык: Английский
Процитировано
10
The Lancet Infectious Diseases, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2