Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1228 - 1228

Опубликована: Янв. 19, 2024

The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in body. Existing evidence suggests that nutrients can influence modulation gut microbiota. However, there still limited regarding effects vitamin mineral supplementation on through epigenetic modification. It plausible maintaining an adequate dietary intake D, iron, fibre, zinc magnesium may have beneficial effect alleviating inflammation body, reducing oxidative stress, improving condition various mechanisms. Moreover, epigenetics involves alterations phenotype cell without changing its fundamental DNA sequence. appears by lead to regulation. correlations between are interdependent. Therefore, primary objective this review identify complex relationships diet, microbiota, These interactions could play crucial role systemic health.

Язык: Английский

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Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age

PLoS Biology, Год журнала: 2023, Номер 21(8), С. e3002230 - e3002230

Опубликована: Авг. 17, 2023

Human microbiome variation is linked to the incidence, prevalence, and mortality of many diseases associates with race ethnicity in United States. However, age at which variability emerges between these groups remains a central gap knowledge. Here, we identify that gut associated arises after 3 months persists through childhood. One-third bacterial taxa vary across caregiver-identified racial categories children are reported also adults. Machine learning modeling childhood microbiomes from 8 cohort studies (2,756 samples 729 children) distinguishes ethnic 87% accuracy. Importantly, predictive genera among top 30 most important when used predict adult self-identified ethnicity. Our results highlight critical developmental window or shortly social environmental factors drive ethnicity-associated may contribute health disparities.

Язык: Английский

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In vitro digestibility of bioprocessed Brewer’s spent yeast: Demonstrating protein quality and gut microbiome modulation potential

Food Research International, Год журнала: 2025, Номер 202, С. 115732 - 115732

Опубликована: Янв. 11, 2025

Язык: Английский

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Robust cross-cohort gut microbiome associations with COVID-19 severity

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Авг. 7, 2023

Although many recent studies have examined associations between the gut microbiome and COVID-19 disease severity in individual patient cohorts, questions remain on robustness across international cohorts of biomarkers they reported. Here, we performed a meta-analysis eight shotgun metagenomic patients (comprising 1,023 stool samples) 23 > 16S rRNA gene amplicon sequencing (16S) (2,415 total samples). We found that (as defined by WHO clinical progression scale) was associated with taxonomic functional differences. This alteration configuration peaks at days 7–30 post diagnosis, after which returns to becomes more similar healthy controls over time. Furthermore, identified core set species were consistently whose abundance can accurately predict category SARS-CoV-2 infected subjects, Actinomyces oris predicting population-level mortality rate COVID-19. Additionally, used relational diet-microbiome databases constructed from cohort microbiota-targeted diet patterns would modulate microbiota composition toward controls. Finally, demonstrated association intestinal archaeal, fungal, viral, parasitic communities. Collectively, this study has robust biomarkers, established accurate predictive models as basis for prognostic tests severity, proposed biomarker-targeted diets managing infection.

Язык: Английский

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Designing healthier bread through the lens of the gut microbiota

Trends in Food Science & Technology, Год журнала: 2023, Номер 134, С. 13 - 28

Опубликована: Фев. 8, 2023

Food systems worldwide have become industrialized over the past century with impacts on diets, nutrition and health. The trade-offs between affordability higher-quality diets can be exemplified by industrially produced, refined wheat bread. There is substantial demand for designing healthier bread, host-microbiota commensalism has emerged as a key factor in food product development aiming to deliver health benefits. Based pre-clinical clinical studies, this review provides an overview of main strategies healthy bread from microbiota perspective. We also discuss how microbiota-based precision harnessed design tailored specific individuals or populations. In addition being important source dietary fiber phytochemicals, largest contributor intake common additives countries consuming Western-like ramifications disease via gut microbiota. Pre-clinical small-scale studies suggest that use alternative grains, supplementation induce functional properties sourdough fermentation hold great potential reducing risk factors associated diet-related non-communicable diseases modulating Nevertheless, ingredients formulated may need applied targeted individual-specific manner expected benefits avoid potentially detrimental consequences. Overall, we identify major knowledge gaps research opportunities developing gut-friendly breads scientifically validated

Язык: Английский

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The human gut phageome: composition, development, and alterations in disease

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июль 5, 2023

The human gastrointestinal tract is colonized by a large number of microorganisms, including bacteria, archaea, viruses, and eukaryotes. bacterial community has been widely confirmed to have significant impact on health, while particularly phages, received less attention. Phages are viruses that specifically infect bacteria. They abundant in the biosphere exist symbiotic relationship with their host Although application high-throughput sequencing bioinformatics technology greatly improved our understanding genomic diversity, taxonomic composition, spatio-temporal dynamics gut phageome, there still portion data uncharacterized. Preliminary studies predicted phages play crucial role driving microbial ecology evolution. Prior exploring function it necessary address obstacles hinder establishing comprehensive database sufficient biological properties phage-bacteria interactions health. In this study, we provide an overview its structure, development. We also explore various factors may influence phageome based current research, age, diet, ethnicity, geographical location. Additionally, summarize between diseases, such as IBD, IBS, obesity, diabetes, metabolic syndrome.

Язык: Английский

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The heart of the matter: How gut microbiota-targeted interventions influence cardiovascular diseases

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155931 - 155931

Опубликована: Март 1, 2025

Язык: Английский

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Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 7, 2024

Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction without reliable cure. Evidence suggests that an alteration the gut microbiome may contribute to IBS pathogenesis, motivating development microbiome-targeted therapies alleviate symptoms. However, IBS-specific signatures are variable across cohorts. A total 9204 datasets were meta-analyzed, derived from fourteen discovery cohorts, three validation cohorts for diet-microbiome interactions, and five rifaximin therapy The consistent bacterial species functional associated with identified. Network analysis revealed two distinct IBS-enriched microbiota clusters; obligate anaerobes found commonly in gut, facultative typically present mouth, implying possible association between oral translocation pathogenesis. By analyzing microbiota-targeted diets can potentially modulate altered subjects toward healthy status Furthermore, treatment was linked reduction abundance facultatively anaerobic pathobionts. Gut identified inform modulation IBS. diet patterns described enable nutritional intervention trials assisting dietary management.

Язык: Английский

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Dietary Assessment and Metabolomic Methodologies in Human Feeding Studies: A Scoping Review

Advances in Nutrition, Год журнала: 2023, Номер 14(6), С. 1453 - 1465

Опубликована: Авг. 19, 2023

Dietary metabolomics is a relatively objective approach to identifying new biomarkers of dietary intake and for use alongside traditional methods. However, methods used across feeding studies vary, thus making it challenging compare results. To synthesize methodological components controlled human designed quantify the diet-related metabolome in biospecimens, including plasma, serum, urine following interventions. Six electronic databases were searched. Included (1) conducted healthy adults; (2) intervention studies; (3) focusing on patterns; (4) measured metabolome. From 12,425 texts, 50 met all inclusion criteria. Interventions primarily cross-over (n=25) parallel RCTs (n=22), with between 8 395 participants. Seventeen different patterns tested, most common being "High versus Low Glycaemic Index/Load" pattern (n=11) "Typical Country Intake" (n=11); 32 providing or majority (90%) food, 16 some two no food. Metabolites identified (n=31) plasma/serum (n=30). quantified using liquid chromatography, mass spectroscopy untargeted (n=37). There was extensive variability examining metabolome, biospecimen sample collection, metabolomic analysis techniques. improve comparability reproducibility important provide detailed information about interventions included restricted foods, food groups, meal plans provided. Strategies control individual variability, such as study design, statistical adjustment methods, dietary-controlled run-in periods, standardized meals test foods throughout should also be considered. The protocol this review has been registered at Open Science Framework (https://doi.org/10.17605/OSF.IO/DAHGS).

Язык: Английский

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The Gut Virome and Human Health: From Diversity to Personalized Medicine

Engineering Microbiology, Год журнала: 2025, Номер unknown, С. 100191 - 100191

Опубликована: Фев. 1, 2025

Язык: Английский

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