Common principles for odour coding across vertebrates and invertebrates
Nature reviews. Neuroscience,
Год журнала:
2024,
Номер
25(7), С. 453 - 472
Опубликована: Май 28, 2024
Язык: Английский
Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 22, 2025
While
animals
readily
adjust
their
behavior
to
adapt
relevant
changes
in
the
environment,
neural
pathways
enabling
these
remain
largely
unknown.
Here,
using
multiphoton
imaging,
we
investigate
whether
feedback
from
piriform
cortex
olfactory
bulb
supports
such
behavioral
flexibility.
To
this
end,
engage
head-fixed
male
mice
a
multimodal
rule-reversal
task
guided
by
and
auditory
cues.
Both
odor
and,
surprisingly,
sound
cues
trigger
responses
cortical
bulbar
axons
which
precede
report.
Responses
same
sensory
cue
are
strongly
modulated
upon
stimulus-reward
contingency
(rule-reversals).
The
re-shaping
of
individual
bouton
occurs
within
seconds
events
is
correlated
with
behavior.
Optogenetic
perturbation
disrupts
performance.
Our
results
indicate
that
piriform-to-olfactory
carry
stimulus
identity
reward
signals
rapidly
re-formatted
according
context.
Hernandez-Trejo,
Ciuparu,
Garcia
da
Silva
et
al.
report
mouse
carries
signals,
seconds,
Язык: Английский
Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells
PLoS Biology,
Год журнала:
2024,
Номер
22(3), С. e3002536 - e3002536
Опубликована: Март 1, 2024
Associating
values
to
environmental
cues
is
a
critical
aspect
of
learning
from
experiences,
allowing
animals
predict
and
maximise
future
rewards.
Value-related
signals
in
the
brain
were
once
considered
property
higher
sensory
regions,
but
their
wide
distribution
across
many
regions
increasingly
recognised.
Here,
we
investigate
how
reward-related
begin
be
incorporated,
mechanistically,
at
earliest
stage
olfactory
processing,
namely,
bulb.
In
head-fixed
mice
performing
Go/No-Go
discrimination
closely
related
mixtures,
rewarded
odours
evoke
widespread
inhibition
one
class
output
neurons,
that
is,
mitral
cells
not
tufted
cells.
The
temporal
characteristics
this
suggest
it
odour-driven,
also
context-dependent
since
absent
during
pseudo-conditioning
pharmacological
silencing
piriform
cortex.
Further,
modulation
present
somata
apical
dendritic
tuft
cells,
suggesting
an
involvement
circuit
components
located
deep
Depth-resolved
imaging
granule
cell
gemmules
suggests
target
receive
extrinsic
drive.
Thus,
our
study
supports
notion
value-related
characteristic
processing
primary
area
narrows
down
possible
underlying
mechanisms
deeper
contact
perisomatically.
Язык: Английский
Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 8, 2024
Abstract
Inhibitory
circuits
in
the
mammalian
olfactory
bulb
(OB)
dynamically
reformat
information
as
it
propagates
from
peripheral
receptors
to
downstream
cortex.
To
gain
mechanistic
insight
into
how
specific
OB
interneuron
types
support
this
sensory
processing,
we
examine
unitary
synaptic
interactions
between
excitatory
mitral
and
tufted
cells
(MTCs),
projection
cells,
a
conserved
population
of
anaxonic
external
plexiform
layer
interneurons
(EPL-INs)
using
pair
quartet
whole-cell
recordings
acute
mouse
brain
slices.
Physiological,
morphological,
neurochemical,
analyses
divide
EPL-INs
distinct
subtypes
reveal
that
parvalbumin-expressing
fast-spiking
(FSIs)
perisomatically
innervate
MTCs
with
release-competent
dendrites
synaptically
detonate
mediate
fast,
short-latency
recurrent
lateral
inhibition.
Sparse
MTC
synchronization
supralinearly
increases
high-fidelity
inhibition,
while
afferent
activation
combined
single-cell
silencing
reveals
individual
FSIs
account
for
substantial
fraction
total
network-driven
output
is
thus
powerfully
shaped
by
detonation-driven
perisomatic
Язык: Английский
Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb
PLoS Biology,
Год журнала:
2024,
Номер
22(8), С. e3002660 - e3002660
Опубликована: Авг. 26, 2024
Inhibitory
circuits
in
the
mammalian
olfactory
bulb
(OB)
dynamically
reformat
information
as
it
propagates
from
peripheral
receptors
to
downstream
cortex.
To
gain
mechanistic
insight
into
how
specific
OB
interneuron
types
support
this
sensory
processing,
we
examine
unitary
synaptic
interactions
between
excitatory
mitral
and
tufted
cells
(MTCs),
projection
neurons,
a
conserved
population
of
anaxonic
external
plexiform
layer
interneurons
(EPL-INs)
using
pair
quartet
whole-cell
recordings
acute
mouse
brain
slices.
Physiological,
morphological,
neurochemical,
analyses
divide
EPL-INs
distinct
subtypes
reveal
that
parvalbumin-expressing
fast-spiking
(FSIs)
perisomatically
innervate
MTCs
with
release-competent
dendrites
synaptically
detonate
mediate
fast,
short-latency
recurrent
lateral
inhibition.
Sparse
MTC
synchronization
supralinearly
increases
high-fidelity
inhibition,
while
afferent
activation
combined
single-cell
silencing
reveals
individual
FSIs
account
for
substantial
fraction
total
network-driven
output
is
thus
powerfully
shaped
by
detonation-driven
perisomatic
Язык: Английский