Aversive memory engrams in the hippocampus
Brain Organoid and Systems Neuroscience Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Effects of ketamine on fear memory extinction: a review of preclinical literature
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 30, 2025
Ketamine,
a
multimodal
dissociative
anesthetic,
is
widely
used
as
trauma
analgesic
in
emergency
situations.
Ketamine
also
to
treat
psychiatric
disorders
due
its
broad
application
potential,
including
treatment-resistant
major
depression.
However,
impacts
on
the
development
of
post-traumatic
stress
disorder
(PTSD)
and
potential
treatment
for
PTSD
are
controversial.
marked
by
persistent
intrusive
memories
traumatic
event(s)
re-experiencing
when
exposed
trauma-related
stimuli.
Individuals
with
often
treated
prolonged
exposure
therapy
(PE),
which
they
gradually
stimuli
that
remind
them
previous
memory.
If
successful,
may
learn
previously
no
longer
threatening,
process
known
fear
extinction.
Although
extinction
can
be
studied
laboratory
animals,
preclinical
literature
effects
ketamine
has
been
inconsistent.
Thus,
we
summarized
existing
examining
molecular
mechanisms.
Studies
found
enhance,
impair,
have
effect,
or
mixed
These
discrepancies
attributed
differences
dosage,
route,
timing
administration.
We
conclude
review
recommendations
future
research
such
inclusion
more
female
subjects,
clinically
relevant
doses
routes
administration,
comprehensive
behavioral
assays
humans
enhance
translation
between
clinical
research.
Язык: Английский
Dynamic memory enqrams: Unveiling the celular mechanisms of memory encoding, consolidation, generalizaton, and updating in the brain
Brain medicine :,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Май 20, 2025
One
of
the
fundamental
questions
neuroscience
is
how
brain
can
store,
generalize,
and
update
memories.
Memories
are
believed
to
be
stored
through
biophysical
molecular
changes
in
neuronal
ensembles
called
engrams,
which
distributed
across
different
regions.
The
dynamic
that
occur
engram
cells
during
encoding,
consolidation,
generalization,
updating
memory
still
not
fully
understood.
However,
recent
advancements
techniques
for
labeling
manipulating
neural
activity
have
allowed
investigation
engrams
processes.
Understanding
dynamics
may
inform
interventions
posttraumatic
stress
disorder
disorders.
In
this
review,
we
summarize
progress
updating,
shedding
new
light
on
mechanisms
underlying
formation
maturation.
Язык: Английский