An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI Creative Commons
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

Gates Open Research, Год журнала: 2024, Номер 8, С. 143 - 143

Опубликована: Дек. 23, 2024

Typhoid fever is a significant public health problem endemic in Southeast Asia and Sub-Saharan Africa. Antimicrobial treatment of typhoid however threatened by the increasing prevalence antimicrobial resistant (AMR) S. Typhi, especially globally successful lineage (4.3.1) which has rapidly spread East Southern AMR elements can be found either on plasmids or one three chromosomal integration sites, there variability this across lineage. Several previous studies with Malawian isolates indicated clonal, locally spreading chromosomally integrated resistance genes. In recent study we noted predicted genes unusual for region, here present resolved genomes these using long- short-read sequencing. Our work shows that are potentially imported cases, most closely related to recently described sub-lineage 4.3.1.EA1, although they encode IncHI1 reduced gene repertoire compared main Similar were reported large-scale five from Tanzania, highlighting urgency better coverage African continent genome understand dynamics co-circulating plasmids.

Язык: Английский

Surface-Functionalized Bacteria: Frontier Explorations in Next-Generation Live Biotherapeutics DOI
Jianqing Jiang, Fanhui Kong, Qi Lei

и другие.

Biomaterials, Год журнала: 2024, Номер 317, С. 123029 - 123029

Опубликована: Дек. 15, 2024

Язык: Английский

Процитировано

2
Characteristics of phage-plasmids and their impact on microbial communities DOI Creative Commons

Ruweyda Sayid,

Anne W.M. van den Hurk,

Daniela Rothschild-Rodriguez

и другие.

Essays in Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Abstract Bacteria host various foreign genetic elements, most notably plasmids and bacteriophages (or phages). Historically, these two classes were seen as separate, but recent research has shown considerable interplay between them. Phage-plasmids (P-Ps) exhibit characteristics of both phages plasmids, allowing them to exist extrachromosomally within bacterial hosts also infect lyse bacteria phages. This dual functionality enables P-Ps utilize the modes transmission phage facilitating rapid dissemination material, including antibiotic resistance virulence genes, throughout populations. Additionally, have been found encode toxin-antitoxin CRISPR-Cas adaptive immune systems, which enhance survival under stress provide immunity against other elements. Despite a growing body literature on P-Ps, large gaps remain in our understanding their ecological roles environmental prevalence. review aims synthesise existing knowledge identify impacts microbial communities.

Язык: Английский

Процитировано

1
An exploration of unusual antimicrobial resistance phenotypes inSalmonellaTyphi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI Creative Commons
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Abstract Typhoid fever is a significant public health problem endemic in Southeast Asia and Sub- Saharan Africa. Antimicrobial treatment of typhoid however threatened by the increasing prevalence antimicrobial resistant (AMR) S. Typhi, especially globally successful lineage (4.3.1) which has rapidly spread East Southern AMR elements can be found either on plasmids or one three chromosomal integration sites, there variability this across lineage. Several previous studies with Malawian isolates indicated clonal, locally spreading chromosomally integrated resistance genes. In recent study we noted unusual predicted profiles, here present resolved genomes these using long- short-read sequencing. Our work shows that are potentially imported cases, most closely related to recently described sub-lineage 4.3.1.EA1, encode IncHI1 reduced profiles compared major reference sequence Similar were reported large-scale five from Tanzania, highlighting urgency for better coverage African continent genome understand dynamics co-circulating plasmids.

Язык: Английский

Процитировано

0
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

VeriXiv, Год журнала: 2024, Номер 1, С. 9 - 9

Опубликована: Сен. 17, 2024

Typhoid fever is a significant public health problem endemic in Southeast Asia and Sub-Saharan Africa. Antimicrobial treatment of typhoid however threatened by the increasing prevalence antimicrobial resistant (AMR) S. Typhi, especially globally successful lineage (4.3.1) which has rapidly spread East Southern AMR elements can be found either on plasmids or one three chromosomal integration sites, there variability this across lineage. Several previous studies with Malawian isolates indicated clonal, locally spreading chromosomally integrated resistance genes. In recent study we noted unusual predicted profiles, here present resolved genomes these using long- short-read sequencing. Our work shows that are potentially imported cases, most closely related to recently described sub-lineage 4.3.1.EA1, encode IncHI1 reduced profiles compared major reference sequence Similar were reported large-scale five from Tanzania, highlighting urgency for better coverage African continent genome understand dynamics co-circulating plasmids.

Язык: Английский

Процитировано

0
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

0
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

Опубликована: Дек. 20, 2024

Язык: Английский

Процитировано

0
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids DOI Creative Commons
Allan Zuza, Alexander M. Wailan, Catherine Anscombe

и другие.

Gates Open Research, Год журнала: 2024, Номер 8, С. 143 - 143

Опубликована: Дек. 23, 2024

Typhoid fever is a significant public health problem endemic in Southeast Asia and Sub-Saharan Africa. Antimicrobial treatment of typhoid however threatened by the increasing prevalence antimicrobial resistant (AMR) S. Typhi, especially globally successful lineage (4.3.1) which has rapidly spread East Southern AMR elements can be found either on plasmids or one three chromosomal integration sites, there variability this across lineage. Several previous studies with Malawian isolates indicated clonal, locally spreading chromosomally integrated resistance genes. In recent study we noted predicted genes unusual for region, here present resolved genomes these using long- short-read sequencing. Our work shows that are potentially imported cases, most closely related to recently described sub-lineage 4.3.1.EA1, although they encode IncHI1 reduced gene repertoire compared main Similar were reported large-scale five from Tanzania, highlighting urgency better coverage African continent genome understand dynamics co-circulating plasmids.

Язык: Английский

Процитировано

0