Biological Effects of Magnetic Storms and ELF Magnetic Fields

Biology, Год журнала: 2023, Номер 12(12), С. 1506 - 1506

Опубликована: Дек. 8, 2023

Magnetic fields are a constant and essential part of our environment. The main components ambient magnetic the geomagnetic field, its fluctuations caused by storms, man-made fields. These refer to extremely-low-frequency (<1 kHz) (ELF-MFs). Since 1980s, huge amount data has been accumulated on biological effects fields, in particular ELF-MFs. However, unified picture patterns action not formed. Even though mechanism yet generally accepted, several theories have proposed. In this review, we attempted take new approach analyzing quantitative ELF-MFs identify potential areas for research. This review provides general descriptions storms anthropogenic living organisms (molecular-cellular level whole organism) brief description mechanisms field organisms. may be interest specialists biology, physics, medicine, other interdisciplinary areas.

Язык: Английский

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Quantum Control of Radical-Pair Dynamics beyond Time-Local Optimization

PRX Quantum, Год журнала: 2024, Номер 5(2)

Опубликована: Апрель 4, 2024

We realize arbitrary-wave-form-based control of spin-selective recombination reactions radical pairs in the low-magnetic-field regime. To this end, we extend gradient-ascent pulse engineering (GRAPE) paradigm to allow for optimizing reaction yields. This overcomes drawbacks previously suggested time-local optimization approaches pairs, which were limited high biasing fields. demonstrate how efficient time-global yields can be realized by gradient-based methods augmented time blocking, sparse sampling yield, and evaluation central single time-step propagators their Fréchet derivatives using iterated Trotter-Suzuki splittings. Results are shown both a toy model, used coherent radical-pair simpler high-field scenario and, furthermore, realistic exciplex-forming donor-acceptor system comprising 16 nuclear spins. raises prospects spin actual systems ambient magnetic fields, suppressing or boosting purpose-specific radio-frequency wave forms, paving way reaction-yield-dependent quantum magnetometry potentially applications biochemical reactions. latter aspect two implicated biology.2 MoreReceived 26 June 2023Revised 15 January 2024Accepted 7 March 2024DOI:https://doi.org/10.1103/PRXQuantum.5.020303Published American Physical Society under terms Creative Commons Attribution 4.0 International license. Further distribution work must maintain attribution author(s) published article's title, journal citation, DOI.Published SocietyPhysics Subject Headings (PhySH)Research AreasChemical reactionsCoherent controlQuantum controlSpin coherenceSpin dynamicsPhysical SystemsQuantum modelsQuantum Information, Science & TechnologyAtomic, Molecular OpticalPhysics Living SystemsCondensed Matter, Materials Applied PhysicsInterdisciplinary Physics

Язык: Английский

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On the optimality of the radical-pair quantum compass

Quantum Science and Technology, Год журнала: 2024, Номер 9(3), С. 035041 - 035041

Опубликована: Май 8, 2024

Abstract Quantum sensing enables the ultimate precision attainable in parameter estimation. Circumstantial evidence suggests that certain organisms, most notably migratory songbirds, also harness quantum-enhanced magnetic field via a radical-pair-based chemical compass for precise detection of weak geomagnetic field. However, what underpins acuity such operating noisy biological setting, at physiological temperatures, remains an open question. Here, we address fundamental limits inferring directions from radical-pair spin dynamics. Specifically, compare precision, as derived directional dependence recombination yield, to potentially realisable by quantum measurement on system under steady-state conditions. To this end, probe Fisher information and associated Cramér–Rao bound models realistic complexity, accounting complex inter-radical interactions, multitude hyperfine couplings, asymmetric kinetics, characteristic magnetosensory protein cryptochrome. We several implicated cryptochrome magnetoreception unveil their optimality through measurements ostensibly accessible nature. Overall, comparison provides insight into processes honed nature realise whilst constrained with mere reaction yields. Generally, inference orientation yields approaches yet levels off short theoretical optimal bounds up one or two orders magnitude, thus underscoring potential improving design principles inherent natural systems.

Язык: Английский

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Structural Rearrangements of Pigeon Cryptochrome 4 Undergoing a Complete Redox Cycle

The Journal of Physical Chemistry B, Год журнала: 2024, Номер 128(16), С. 3844 - 3855

Опубликована: Апрель 3, 2024

Cryptochrome is currently the major contender of a protein to underpin magnetoreception, ability sense Earth's magnetic field. Among various types cryptochromes, cryptochrome 4 has been identified as likely magnetoreceptor in migratory birds. All-atom molecular dynamics (MD) studies have offered first insights into structural but are limited short time scale due large computational demands. Here, we employ coarse-grained MD simulations investigate emergence long-lived states and conformational changes pigeon 4. Our complete picture by permitting observation on significantly longer scale. We observe transitions phosphate-binding loop upon activation identify prominent motions residues 440–460, suggesting possible role signaling state or gated interaction site for forming complexes that might facilitate downstream processes. The findings highlight importance considering scales studying magnetoreception. Coarse-grained offer valuable tool unravel complex behavior proteins shed new light mechanisms underlying their Further exploration these functional implications may contribute deeper understanding magnetoreception

Язык: Английский

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A structural decryption of cryptochromes

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Авг. 16, 2024

Cryptochromes (CRYs), which are signaling proteins related to DNA photolyases, play pivotal roles in sensory responses throughout biology, including growth and development, metabolic regulation, circadian rhythm entrainment geomagnetic field sensing. This review explores the evolutionary relationships functional diversity of cryptochromes from perspective their molecular structures. In general, CRY biological activities derive core structural architecture, is based on a Photolyase Homology Region (PHR) more variable functionally specific Cryptochrome C-terminal Extension (CCE). The α/β α-helical domains within PHR bind FAD, modulate redox reactive residues, accommodate antenna cofactors, recognize small molecules provide conformationally responsive interaction surfaces for range partners. CCEs add complexity divergence, doing so, influence photoreceptor reactivity tailor function. Primary secondary pockets myriad moieties collaborate with tune recognition properties propagate chemical changes downstream For some CRYs, homo hetero-oligomerization couple light-induced conformational changes, others, posttranslational modifications cascades protein interactions partners effectors. exploration underscores how broad family close relationship light-dependent enzymes achieves wide through conservation key upon function-specific features elaborated.

Язык: Английский

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Molecular hydrogen: a sustainable strategy for agricultural and food production challenges

Frontiers in Food Science and Technology, Год журнала: 2024, Номер 4

Опубликована: Сен. 18, 2024

The world is confronting numerous challenges, including global warming, health epidemics, and population growth, each presenting significant threats to the stability sustainability of our planet’s ecosystems. Such issues have collectively contributed a reduction in agricultural productivity, corresponding with an increase demand costs essential commodities. This critical situation requires more sustainable environmental, social, technological solutions. Molecular hydrogen (H 2 ) has been suggested as “green” solution for energy needs many health, agricultural, food applications. H supplementation agriculture may represent novel low-carbon biotechnological strategy applicable abundant production crops, vegetables, fruits agri-food chains. potential green alternative conventional chemical fertilizers. use hydrogen-rich water irrigation system also provide other health-related advantages, i.e., decreasing heavy metal accumulation crops. By adopting strategy, crop producers, processors, decision-makers can contribute solutions face challenges such climate change, communicable disease growing population. versatile applications H₂ wider industry position it uniquely suitable approach address today’s potentially fostering better positively impacting chain. present review timely combining latest knowledge about industry, from farm fork.

Язык: Английский

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Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects

Redox Biology, Год журнала: 2024, Номер 72, С. 103152 - 103152

Опубликована: Апрель 5, 2024

Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that sensitive applied radiofrequency (RF) and weak fields (WEMFs), known as pair mechanism (RPM). As a leading model, the RPM explains how quantum can influence biochemical cellular signalling. Consequently, generate reactive oxygen species (ROS) link redox processes, such response hypoxia circadian clock. Therapeutic nuclear resonance (tNMR) occupies unique position in paradigm because used frequencies, which far below range 0.1-100 MHz postulated for occur. Nonetheless, tNMR was shown induce like effects, increased extracellular H2O2 levels altered bioenergetics. In this study we compared impact intermittent clock, well role superoxide induced ROS partitioning. We show both, hypoxia, exert on/off clocks dependent time application (day versus night). addition, our data provide further evidence plays central signal transduction. combination with scavengers, Vitamin C, led strong product redistributions. This discovery might represent first indication triads biological systems.

Язык: Английский

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Hypomagnetic field effects as a potential avenue for testing the radical pair mechanism in biology

Frontiers in Physics, Год журнала: 2023, Номер 11

Опубликована: Янв. 24, 2023

Near-zero magnetic fields, called hypomagnetic are known to impact biological phenomena, including developmental processes, the circadian system, neuronal and brain activities, DNA methylation, calcium balance in cells, many more. However, exact mechanism underlying such effects is still elusive, as corresponding energies far smaller than thermal energies. It that chemical reactions involving radical pairs can be field dependent at very low intensities comparable or less geomagnetic field. Here, we review detail from perspective of pair mechanism, pointing out under certain conditions, they even stronger increasing We suggest an interesting avenue for testing biology.

Язык: Английский

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Theoretical evaluation of the biological activity of hydrogen

Medical Gas Research, Год журнала: 2025, Номер 15(2), С. 266 - 275

Опубликована: Янв. 18, 2025

Hydrogen (H 2 ), the simplest and most ubiquitous molecule in universe, has garnered significant scientific interest over past two decades because of its potential as an effective antioxidant anti-inflammatory agent. Traditionally considered inert, H is now being re-evaluated for unique bioactive properties. selectively neutralizes reactive oxygen nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation biological activity , focusing on pharmacokinetics, including absorption, distribution, retention within systems. The pharmacokinetic profile crucial understanding therapeutic applications. interaction with protein pockets particular interest, these sites may serve reservoirs or active influencing time. Additionally, impact signaling pathways, those regulating glucose metabolism responses, will be explored, offering insights into modulator metabolic redox homeostasis. Finally, interactions ferromagnetic molecules environments, well effects mechanisms, add another layer complexity role . By synthesizing current research, this seeks elucidate underlying mechanisms by which exert while also identifying critical areas further investigation. Understanding aspects fully characterizing pharmacodynamic assessing clinical treatment stress–related disorders.

Язык: Английский

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Magnetoreception in cryptochrome enabled by one-dimensional radical motion

AVS Quantum Science, Год журнала: 2023, Номер 5(2)

Опубликована: Апрель 7, 2023

A popular hypothesis ascribes magnetoreception to a magnetosensitive recombination reaction of pair radicals in the protein cryptochrome. Many theoretical studies this model have ignored inter-radical interactions, particularly electron–electron dipolar (EED) coupling, which detrimental effect on magnetosensitivity. Here, we set out elucidate if radical allowed undergo internal motion can yield enhanced magneto-sensitivity. Our considers effects diffusive one partner along one-dimensional coordinate. Such dynamics could, principle, be realized either via actual diffusion mobile through channel or bound pairs subjected structural rearrangements and fluctuations. We demonstrate that suppressive EED interactions alleviated these scenarios as result quantum Zeno intermittent reduction coupling during radical's excursions. results highlight importance dynamic environment entwined with ensuing magnetosensitivity under strong where it had not previously been anticipated, triplet-born develop superior sensitivity over singlet-born one.

Язык: Английский

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