Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Fish Physiology and Biochemistry, Год журнала: 2025, Номер 51(1)
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
1Aquaculture, Год журнала: 2025, Номер unknown, С. 742173 - 742173
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Год журнала: 2025, Номер unknown, С. 111804 - 111804
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Marine Biotechnology, Год журнала: 2025, Номер 27(1)
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0Aquaculture, Год журнала: 2025, Номер unknown, С. 742461 - 742461
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Genes, Год журнала: 2024, Номер 15(9), С. 1238 - 1238
Опубликована: Сен. 23, 2024
17α-Methyltestosterone (MT) is a widely used androgen for all-male fish production in aquaculture. However, the molecular mechanism underlying MT-induced masculinization remains unclear. In this study, we aim to identify key gene responsible using Nile tilapia (Oreochromis niloticus) amhy, dmrt1, and gsdf mutants, which exhibit male-to-female sex reversal. fry from these three mutant lines were treated with 50 μg/g MT 5 30 days after hatching (dah). The results showed that amhy but not dmrt1 masculinized by treatment. Gonadal transcriptome analysis revealed genes involved steroidogenesis germ cell development MT-treated mutants exhibited similar expression pattern of wild type (WT) XX. addition, cannot be co-treatment aromatase inhibitor fadrozole. treatment completely blocked early steroidogenic enzyme (Star2, Cyp17a2, Cyp19a1a) independent gsdf, dmrt1. A luciferase directly suppressed basal Sf-1-activated cyp19a1a promoter activity through ara arb cultured HEK293 cells. Furthermore, inhibited proliferation mutants. Consistently, was induced WT XX, -amhy, -gsdf Taken together, suggest indispensable functions inhibiting steroid synthesis activating promote testis development.
Язык: Английский
Процитировано
2Andrology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 27, 2024
Oligoasthenoteratozoospermia (OAT) is a common cause of male infertility, which the causes remain largely unknown. Recently, BCORL1 was identified as contributor to infertility from non-obstructive azoospermia (NOA) OAT.
Язык: Английский
Процитировано
1Aquaculture Reports, Год журнала: 2024, Номер 37, С. 102247 - 102247
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
0BMC Veterinary Research, Год журнала: 2024, Номер 20(1)
Опубликована: Июль 19, 2024
Abstract To evaluate Tribulus terrestris and Mucuna pruriens for inducing all-male tilapia, mixed-sex Nile Oreochromis niloticus, (mean weight 0.025 ± 0.009 g; mean length 1.25 0.012 cm) , were given a meal supplemented with either T. powder (commercial fish feed, 40% crude protein) (TT group), M. seed extract (MP MP + TT (mixed 17α-methyl testosterone (MT, control positive), or without supplements (control negative). The extracts significantly increased ( P < 0.05) the final weight, gain, gain rate, specific growth rate while feed conversion ratio was decreased 0.05). Plant markedly improved survival proportion of males, total compared to MT. Estrogen levels lower in groups plant than other groups. Fifteen days post-feeding, Amh gene expressed brain O. niloticus fries higher MP, TT, MT Additionally, expression Sox9 Dmrt1 genes as male related fry gonads revealed fed on after 30-day whereas; Foxl2 female 30 post feeding. Histologically, MT, mixture all exhibited solely reproductive traits noticeable abnormalities. This study concluded that each can induce sex reversal tilapia having no negative health impact treated group
Язык: Английский
Процитировано
0