Social health and prevention of dementia: Integration of human and mice studies

International Psychogeriatrics, Год журнала: 2025, Номер unknown, С. 100054 - 100054

Опубликована: Март 1, 2025

Prevention of dementia is considered a healthcare priority. We aimed to identify potentially modifiable risk factors and mechanisms within the social health domain find novel avenues prevent cognitive decline dementia. integrated results eight sub-studies Social Health in Mice Men (SHiMMy) project that were separately published specialized journals, but not yet jointly considered. followed integrative methodology Whittemore Knafl, using conceptual framework for structure integrate human epidemiological qualitative studies experimental mice studies. This multi-method approach. Participants population-based longitudinal cohort Rotterdam study included epidemiolocal (ranging from N = 1259 3.720) (n 17). intervention performed transgenic mouse model Alzheimer's pathology matched controls, under group single housed conditions. Epidemiological include markers (loneliness, perceived support, marital status) magnetic resonance imaging brain. The semi-structured used an interview guide. assessed behavioral histological markers. In studies, we identified several similar (e.g. status, size) protective responses) factors. alignment findings showing may impact brain lend further support our hypothesis. These allow us propose evidence-based targets preventive interventions.

Язык: Английский

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Symptoms of anxiety/depression during the COVID-19 pandemic and associated lockdown in the community: longitudinal data from the TEMPO cohort in France

BMC Psychiatry, Год журнала: 2021, Номер 21(1)

Опубликована: Июль 28, 2021

Abstract Background To cope with the COVID-19 pandemic, social distancing restrictions where implemented in France, which could have led to isolation. This is expected affected mental health situation, including increasing risk of symptoms anxiety and depression general population. Persons prior difficulties be an especially vulnerable group, however, few studies tested this empirically considering preexisting difficulties. We examine association between anxiety/depression during lockdown due pandemic a longitudinal community sample. Methods A follow-up (data collection March–June 2020) was among participants TEMPO cohort. Prior knowledge included from waves data collection. Generalized estimation equations models were used estimate 662 mid-aged individuals. Results Individuals measured had 6.73 higher odds [95% CI = 4.45–10.17] lockdown. Additionally, likelihood elevated women (OR 2.07 1.32–3.25]), subjects low household income 2.28 [1.29–4.01]) persons who reported being lonely 3.94 2.47–6.28]). Conclusions Our study underlines role as vulnerability factor Interventions focusing on individuals well people feeling should considered, reduce psychological impact pandemic.

Язык: Английский

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Digital interventions to reduce social isolation and loneliness in older adults: An evidence and gap map

Campbell Systematic Reviews, Год журнала: 2023, Номер 19(4)

Опубликована: Ноя. 27, 2023

Social isolation and loneliness are more common in older adults associated with a serious impact on their well-being, mental health, physical longevity. They public health concern highlighted by the COVID-19 pandemic restrictions, hence need for digital technology tools to enable remotely delivered interventions alleviate of social during restrictions.To map available evidence effects mitigate and/or all settings except hospital settings.We searched following databases from inception May 16, 2021, no language restrictions. Ovid MEDLINE, Embase, APA PsycInfo via Ovid, CINAHL EBSCO, Web Science Clarivate, ProQuest (all databases), International Bibliography Sciences (IBSS) ProQuest, EBSCO CINAHL), Global Index Medicus, Epistemonikos.Titles abstracts full text potentially eligible articles were independently screened duplicate eligibility criteria.We developed pilot tested data extraction code set Eppi-Reviewer individually extracted coded based an intervention-outcome framework which was also used define dimensions gap map.We included 200 (103 primary studies 97 systematic reviews) that assessed reduce adults. Most reviews (72%) classified as critically low quality, only 2% high quality 25% published since pandemic. The is unevenly distributed clusters predominantly high-income countries none low-income countries. most identified enhance interactions family friends community videoconferencing telephone calls. Digital support, particularly socially assistive robots, virtual pets common. focused reducing depression improving life Major gaps level outcomes process indicators. No or affordability divide although value accessibility barriers caused discussed three reviews. Adverse reported two six study review participants LGBTQIA2S+ one restricted 80 years older. Very few described how at-risk populations recruited conducted any equity analysis assess differences experiencing inequities across PROGRESS-Plus categories.The restrictions placed people have shone spotlight onto loneliness, This shows effectiveness Although relatively large recent, it there high-quality research. can guide researchers funders consider areas major priorities further

Язык: Английский

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Tackling social disconnection: an umbrella review of RCT-based interventions targeting social isolation and loneliness

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 17, 2024

Abstract Background Social isolation and loneliness are urgent public health concerns associated with negative physical mental outcomes. Understanding effective remedies is crucial in addressing these problems. This umbrella review aimed to synthesize critically appraise scientific evidence on the effectiveness of social interventions overall across subgroups. We focused systematic reviews (SRs) randomized controlled trials (RCTs). Methods searched seven databases (June 2022 updated June 2023) supplemented search grey literature reference screening identify SRs published since 2017. Screening, data extraction, quality assessment using AMSTAR2 tool were conducted independently by author pairs, disagreements resolved through discussion. Results included 29 SRs, 16 meta-analysis 13 narrative synthesis. All loneliness, 12 additionally examining isolation. Four young people, 11 all ages, 14 older adults. The most frequently examined intervention types (social contact, support), psychological (therapy, psychoeducation, skills training), digital (e.g., computer use online support). Meta-analyses indicated small-to-moderate beneficial effects, while synthesis demonstrated mixed or no effect. for promising. However, caution warranted due effects’ small magnitude, significant heterogeneity, variable SRs. Digital other showed effect; however, advised interpreting results highly diverse nature studied. Conclusions overview shows moderate reducing ones tackling loneliness. Further rigorously RCTs needed guide policy decisions regarding implementation efficacious scalable interventions. Evaluation should focus both preventive structural tailored mitigating strategies that address specific causes

Язык: Английский

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Perceived Stress in Dentists and Dental Students of Latin America and the Caribbean during the Mandatory Social Isolation Measures for the COVID-19 Pandemic: A Cross-Sectional Study

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(11), С. 5889 - 5889

Опубликована: Май 30, 2021

This study aims to determine the impact of COVID-19 pandemic, specifically considering mandatory social isolation measures implemented, on perceived stress a sample dentists and dental students from Latin America Caribbean, as well associated sociodemographic pandemic-related variables. A cross-sectional survey was conducted with 2036 (1433 women). For main outcome, 14-item Perceived Stress Scale (PSS-14) used. The also questioned aspects, questions health variables, habits. Descriptive, bivariate, multivariate analyses (linear regression) were applied observe factors stress. PSS-14 mean score 24.76 (±11.76). Hierarchical regression models showed significant variables scores: income level during isolation, having older adults under care self-perceived concern regarding COVID-19, health, Coffee consumption isolation. In general terms, pandemic has influenced personal, social, labor, everyday life staff affected mental this population when is considered. Public policies, strategies, surveillance systems are required for population.

Язык: Английский

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Age differences in the association between loneliness and anxiety symptoms during the COVID-19 pandemic

Psychiatry Research, Год журнала: 2022, Номер 310, С. 114446 - 114446

Опубликована: Фев. 13, 2022

Язык: Английский

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The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic

BJPsych Open, Год журнала: 2022, Номер 8(2)

Опубликована: Март 1, 2022

The COVID-19 pandemic has had profound consequences for population mental health. However, it is less clear whom these effects are sustained.To investigate the prevalence, incidence, prognosis and risk factors symptoms of depression anxiety in a UK cohort over three distinct periods 2020.An online survey was completed by community at points (n = 3097 baseline, n 878 all surveys): April (baseline), July to September (time point 2) November December 3). Participants validated measures on each occasion, we prospectively explored role sociodemographic psychological (loneliness, positive mood perceived worry about COVID-19) as factors.Depression (Patient Health Questionnaire-9 means: 7.69; time 2, 5.53; 3, 6.06) scores (Generalised Anxiety Disorder-7 6.59; 4.60; 4.98) were considerably greater than pre-pandemic norms points. Women reported men. Younger age, history health disorder, more COVID-19-related negative life events, loneliness lower baseline significant predictors poorer 3.The impact persisted some degree. people individuals with prior disorders greatest risk. Easing restrictions resumption social interaction could mitigate mood.

Язык: Английский

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Workplace isolation, loneliness and wellbeing at work: The mediating role of task interdependence and supportive behaviours

Applied Ergonomics, Год журнала: 2022, Номер 106, С. 103894 - 103894

Опубликована: Сен. 22, 2022

Despite the negative impact of social isolation on wellbeing, research has yet to address how organisations may mitigate effects workplace and loneliness. The main objective study is explore mediating role task interdependence supportive behaviours colleagues relationship between wellbeing. A total 137 volunteers completed a survey assessing isolation, loneliness, interdependence, wellbeing at work. SEM analyses supported company While had role, did not mediate relationships findings show that increased opportunities for interpersonal interactions work through greater are enough reverse In contrast, an investment in environment highlighting importance culture.

Язык: Английский

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The Psychological Network of Loneliness Symptoms Among Chinese Residents During the COVID-19 Outbreak

Psychology Research and Behavior Management, Год журнала: 2023, Номер Volume 16, С. 3767 - 3776

Опубликована: Сен. 1, 2023

Social distancing measures implemented during the COVID-19 pandemic have contributed to increased levels of loneliness, but specific interactions between loneliness symptoms in context remain unknown. This study characterized psychological network residents initial wave outbreak China.The recruited 8472 Chinese (61.5% women, aged 33.0±10.6 years) through online snowball sampling. The Six-item De Jong Gierveld Loneliness Scale (DJGLS) was used measure symptoms. Central and bridge emotional social subscales were identified based on centrality indices, respectively. Network stability examined using case-dropping procedures.The nodes separated into two groups, corresponding domains DJGLS. strongest direction association "no reliable people" trustworthy (edge weight=0.546). "No has highest node strength (1.047) network, followed by "emptiness sense" (0.767) (0.749). "Feeling rejection" (1.672) close (0.403) showed first second strengths, Both accuracy tests supported robustness whole network.Interventions targeting central symptom "feeling may be effective for alleviating overall level pandemic-affected residents.

Язык: Английский

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Postpartum loneliness predicts future depressive symptoms: a nationwide Japanese longitudinal study

Archives of Women s Mental Health, Год журнала: 2024, Номер 27(3), С. 447 - 457

Опубликована: Янв. 27, 2024

Язык: Английский

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