Acta Neurologica Belgica, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Biomedicines, Год журнала: 2025, Номер 13(2), С. 332 - 332
Опубликована: Янв. 31, 2025
Background/Objectives: Brain-derived neurotrophic factor (BDNF) has been investigated as a potential mechanistic marker or therapeutic target to manage symptoms such fatigue, pain, depression, and sleep disturbances. However, the variability in BDNF response exercise physical activity (exercise/PA) its clinical relevance symptom management remains unclear. This scoping review assesses existing studies exploring relationships between exercise/PA, symptoms, levels, specifically focusing on disturbances adults. Methods: Relevant indexed PubMed CINAHL were identified. Using systematic software, two reviewers independently screened evaluated full texts, based following criteria: human reporting levels adults, using exercise/PA interventions, assessing (pain, and/or disturbance) outcomes, published English. Results: Of 950 records, 35 records met inclusion criteria. While is broadly supported for managing 74.3% (n = 26) of reported increased only 40% 14) showed significant increases exercise/PA. Only 14% 5) demonstrated relationship changes symptoms. No differences observed different types (e.g., aerobic vs. strength flexibility/stretching) PA. Conclusions: The current literature provides insufficient evidence confirm effectiveness Further investigations are needed validate target.
Язык: Английский
Процитировано
2
Multiple Sclerosis and Related Disorders, Год журнала: 2022, Номер 65, С. 103984 - 103984
Опубликована: Июнь 18, 2022
Язык: Английский
Процитировано
32
Multiple Sclerosis and Related Disorders, Год журнала: 2022, Номер 69, С. 104460 - 104460
Опубликована: Дек. 9, 2022
Язык: Английский
Процитировано
21
The Journal of Tehran University Heart Center, Год журнала: 2024, Номер unknown
Опубликована: Янв. 30, 2024
Background: Among its functions, brain-derived neurotrophic factor (BDNF) regulates endothelial and macrophage activation, possibly playing a role in atherosclerotic plaque pathophysiology. Given contradicting reports, this study sought to investigate whether blood levels of BDNF differed between patients with coronary heart disease (CHD) controls. Methods: We explored PubMed, Embase, Web Science, Cochrane Library for studies comparing CHD Random-effect meta-analysis was conducted calculate the standardized mean differences (SMD) 95% confidence intervals (CI). The Newcastle-Ottawa scale used evaluate quality included articles, statistical analyses were using R version 4.0.4. Results: final analysis comprised 12 investigations covering 1422 cases 929 controls ages 59.66±13.56 53.78±13.61 years, respectively. initial revealed tendency toward low group compared control (SMD= -0.41; CI, -1.12 0.30; P=0.26). After removal outliers, difference achieved -0.56; -0.93 -0.19; P<0.01). Subgroup demonstrated no significant serum plasma (P=0.54); however, subgroup investigating showed that had significantly lower levels. Conclusion: Serum concentrations considerably than healthy Further higher are required on potential as biomarker pathophysiology severity.
Язык: Английский
Процитировано
3
Multiple Sclerosis and Related Disorders, Год журнала: 2025, Номер unknown, С. 106411 - 106411
Опубликована: Март 1, 2025
Progressive multiple sclerosis (PMS) is characterized by ongoing neurodegeneration, which current therapies inadequately address. Exercise therapy has emerged as a potential approach to mitigate this process. To investigate the effects of 16-week progressive resistance training (PRT) on neurodegeneration and neuronal function in people with PMS. In extended-baseline within-person trial, were assessed (i.e. total brain volume (TBV), cortical deep gray matter (CGMV & DGMV) normalized for intercranial volume, default mode network (DMN) sensorimotor (SMN) resting-state functional connectivity blood-based biomarkers (brain-derived neurotrophic factor, neurofilament light, glial fibrillary acidic protein)). Muscle strength changes also measured. Linear mixed model analysis was used assess changes. Thirty participants (20 females; mean age 54 years) significantly improved muscle (3-11 kg). No significant observed nor function. CGMV demonstrated trend towards decline during baseline (-0.0008, 95 %CI:-0.0017, 0.0001, p = 0.10) intervention period (-0.0007, %CI:-0.0016, 0.10), but not follow-up (0.0002, %CI:-0.0007, 0.0011, 0.60). The PRT did affect Further research longer-term exercise interventions warranted.
Язык: Английский
Процитировано
0
Neurotherapeutics, Год журнала: 2025, Номер unknown, С. e00603 - e00603
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Brain Sciences, Год журнала: 2022, Номер 12(6), С. 732 - 732
Опубликована: Июнь 2, 2022
The purpose of this study was to systematically review find if aerobic exercise compared no or any other intervention affects brain plasticity among people with mild cognitive impairment (MCI). Searches were conducted in the Scopus, SciELO, PubMed, Web Science, Science Direct, and Google Scholar databases. included studies randomized control trials (RCTs) written English comprising individuals MCI that evaluated effects training on brain-derived neurotrophic factor (BDNF), structures, activity. quality using PEDro scale for RCTs. Twelve medium high included, which five focused (four articles reported elevation one article changes BDNF levels following exercise), two structures (both increases hippocampus volume activity positive changes, exercise). Research regarding is its infancy. Still, seems be a promising therapy MCI.
Язык: Английский
Процитировано
13
Multiple Sclerosis and Related Disorders, Год журнала: 2023, Номер 71, С. 104567 - 104567
Опубликована: Фев. 12, 2023
Язык: Английский
Процитировано
6
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(5), С. 1880 - 1880
Опубликована: Фев. 27, 2023
Physical rehabilitation and physical activity are known non-pharmacological methods of treating multiple sclerosis. Both lead to an improvement in fitness patients with movement deficits while improving cognitive function coordination. These changes occur through the induction brain plasticity. This review presents basics plasticity response rehabilitation. It also analyzes latest literature evaluating impact traditional methods, as well innovative virtual reality-based on
Язык: Английский
Процитировано
6
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(19), С. 5845 - 5845
Опубликована: Сен. 30, 2024
Background: Multiple sclerosis is a chronic, inflammatory, neurodegenerative autoimmune disease caused by myelin loss in the central nervous system, which leads to motor and non-motor problems. The main objective of this study was explore whether an immersive virtual reality (IVR) exercise programme would be feasible as form physical therapy for people with MS (pwMS). Methods: 18 participants (13 women; 45.06 years) were assigned experimental group (EG, n = 8) control (CG, 10). EG took part twice-weekly IVR exergame programme—ExeRVIEM programme. A randomised, single-blind clinical trial conducted registered clinicaltrials (NCT05870254). Results: intervention safe. completed no adverse effects (no symptoms on Simulator Sickness Questionnaire), high usability (System Usability Scale 90.31%), outstandingly positive post-game experiences (Game Experience Questionnaire 3.10/4). In addition, GE significantly improved several their functional capacities: increased lower limb strength (Five Times Sit-to-Stand Test p 0.042), mobility, reduced fall risk (Timed Up Go Test-simple 0.009; Timed Test-cognitive 0.003). There statistically significant differences between groups. Conclusions: findings support that use exergames pwMS Furthermore, there suggestion possible benefits participants’ abilities, all position promising tool rehabilitation pathology affecting young adults.
Язык: Английский
Процитировано
2