Sclerosis,
Journal Year:
2023,
Volume and Issue:
1(2), P. 68 - 75
Published: June 21, 2023
Multiple
sclerosis
is
an
autoimmune,
inflammatory,
and
chronic
neurodegenerative
disease
caused
by
myelin
loss
in
the
central
nervous
system.
One
strategy
that
shows
evidence
of
numerous
benefits
therapeutic
exercise,
but
these
therapies,
based
on
repetitive
physical
actions,
can
sometimes
be
unmotivating
for
patients.
Our
proposal
suggests
exergame
programme
with
immersive
virtual
reality
(IVR)
feasible
people
multiple
(pwMS)
will
improve
their
function
through
more
motivational
sessions.
We
present
a
protocol
single-blind
randomised
controlled
trial
to
assess
feasibility
impact
functional
capacities
8-week
IVR
(ExeRVIEM
protocol)
pwMS.
Balance,
gait,
risk
falling,
mobility
lower
limb
strength,
fatigue,
handgrip
reaction
times
evaluated.
The
control
group
maintain
usual
activities
scheduled
centre,
experimental
add
ExeRVIEM
(two
sessions
per
week).
Therapies
combination
exercise
explored
this
study
may
offer
new
treatment
approaches
open
lines
research
field
improving
functionality
pwMS,
as
well
motivating
patients
encouraging
adherence
treatment.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 332 - 332
Published: Jan. 31, 2025
Background/Objectives:
Brain-derived
neurotrophic
factor
(BDNF)
has
been
investigated
as
a
potential
mechanistic
marker
or
therapeutic
target
to
manage
symptoms
such
fatigue,
pain,
depression,
and
sleep
disturbances.
However,
the
variability
in
BDNF
response
exercise
physical
activity
(exercise/PA)
its
clinical
relevance
symptom
management
remains
unclear.
This
scoping
review
assesses
existing
studies
exploring
relationships
between
exercise/PA,
symptoms,
levels,
specifically
focusing
on
disturbances
adults.
Methods:
Relevant
indexed
PubMed
CINAHL
were
identified.
Using
systematic
software,
two
reviewers
independently
screened
evaluated
full
texts,
based
following
criteria:
human
reporting
levels
adults,
using
exercise/PA
interventions,
assessing
(pain,
and/or
disturbance)
outcomes,
published
English.
Results:
Of
950
records,
35
records
met
inclusion
criteria.
While
is
broadly
supported
for
managing
74.3%
(n
=
26)
of
reported
increased
only
40%
14)
showed
significant
increases
exercise/PA.
Only
14%
5)
demonstrated
relationship
changes
symptoms.
No
differences
observed
different
types
(e.g.,
aerobic
vs.
strength
flexibility/stretching)
PA.
Conclusions:
The
current
literature
provides
insufficient
evidence
confirm
effectiveness
Further
investigations
are
needed
validate
target.
Multiple Sclerosis and Related Disorders,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106411 - 106411
Published: March 1, 2025
Progressive
multiple
sclerosis
(PMS)
is
characterized
by
ongoing
neurodegeneration,
which
current
therapies
inadequately
address.
Exercise
therapy
has
emerged
as
a
potential
approach
to
mitigate
this
process.
To
investigate
the
effects
of
16-week
progressive
resistance
training
(PRT)
on
neurodegeneration
and
neuronal
function
in
people
with
PMS.
In
extended-baseline
within-person
trial,
were
assessed
(i.e.
total
brain
volume
(TBV),
cortical
deep
gray
matter
(CGMV
&
DGMV)
normalized
for
intercranial
volume,
default
mode
network
(DMN)
sensorimotor
(SMN)
resting-state
functional
connectivity
blood-based
biomarkers
(brain-derived
neurotrophic
factor,
neurofilament
light,
glial
fibrillary
acidic
protein)).
Muscle
strength
changes
also
measured.
Linear
mixed
model
analysis
was
used
assess
changes.
Thirty
participants
(20
females;
mean
age
54
years)
significantly
improved
muscle
(3-11
kg).
No
significant
observed
nor
function.
CGMV
demonstrated
trend
towards
decline
during
baseline
(-0.0008,
95
%CI:-0.0017,
0.0001,
p
=
0.10)
intervention
period
(-0.0007,
%CI:-0.0016,
0.10),
but
not
follow-up
(0.0002,
%CI:-0.0007,
0.0011,
0.60).
The
PRT
did
affect
Further
research
longer-term
exercise
interventions
warranted.
The Journal of Tehran University Heart Center,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 30, 2024
Background:
Among
its
functions,
brain-derived
neurotrophic
factor
(BDNF)
regulates
endothelial
and
macrophage
activation,
possibly
playing
a
role
in
atherosclerotic
plaque
pathophysiology.
Given
contradicting
reports,
this
study
sought
to
investigate
whether
blood
levels
of
BDNF
differed
between
patients
with
coronary
heart
disease
(CHD)
controls.
Methods:
We
explored
PubMed,
Embase,
Web
Science,
Cochrane
Library
for
studies
comparing
CHD
Random-effect
meta-analysis
was
conducted
calculate
the
standardized
mean
differences
(SMD)
95%
confidence
intervals
(CI).
The
Newcastle-Ottawa
scale
used
evaluate
quality
included
articles,
statistical
analyses
were
using
R
version
4.0.4.
Results:
final
analysis
comprised
12
investigations
covering
1422
cases
929
controls
ages
59.66±13.56
53.78±13.61
years,
respectively.
initial
revealed
tendency
toward
low
group
compared
control
(SMD=
-0.41;
CI,
-1.12
0.30;
P=0.26).
After
removal
outliers,
difference
achieved
-0.56;
-0.93
-0.19;
P<0.01).
Subgroup
demonstrated
no
significant
serum
plasma
(P=0.54);
however,
subgroup
investigating
showed
that
had
significantly
lower
levels.
Conclusion:
Serum
concentrations
considerably
than
healthy
Further
higher
are
required
on
potential
as
biomarker
pathophysiology
severity.
Brain Sciences,
Journal Year:
2022,
Volume and Issue:
12(6), P. 732 - 732
Published: June 2, 2022
The
purpose
of
this
study
was
to
systematically
review
find
if
aerobic
exercise
compared
no
or
any
other
intervention
affects
brain
plasticity
among
people
with
mild
cognitive
impairment
(MCI).
Searches
were
conducted
in
the
Scopus,
SciELO,
PubMed,
Web
Science,
Science
Direct,
and
Google
Scholar
databases.
included
studies
randomized
control
trials
(RCTs)
written
English
comprising
individuals
MCI
that
evaluated
effects
training
on
brain-derived
neurotrophic
factor
(BDNF),
structures,
activity.
quality
using
PEDro
scale
for
RCTs.
Twelve
medium
high
included,
which
five
focused
(four
articles
reported
elevation
one
article
changes
BDNF
levels
following
exercise),
two
structures
(both
increases
hippocampus
volume
activity
positive
changes,
exercise).
Research
regarding
is
its
infancy.
Still,
seems
be
a
promising
therapy
MCI.
