Journal of Medical Internet Research,
Год журнала:
2025,
Номер
27, С. e53567 - e53567
Опубликована: Апрель 1, 2025
Background
Artificial
intelligence
(AI)
has
the
potential
to
transform
cancer
diagnosis,
ultimately
leading
better
patient
outcomes.
Objective
We
performed
an
umbrella
review
summarize
and
critically
evaluate
evidence
for
AI-based
imaging
diagnosis
of
cancers.
Methods
PubMed,
Embase,
Web
Science,
Cochrane,
IEEE
databases
were
searched
relevant
systematic
reviews
from
inception
June
19,
2024.
Two
independent
investigators
abstracted
data
assessed
quality
evidence,
using
Joanna
Briggs
Institute
(JBI)
Critical
Appraisal
Checklist
Systematic
Reviews
Research
Syntheses.
further
in
each
meta-analysis
by
applying
Grading
Recommendations,
Assessment,
Development,
Evaluation
(GRADE)
criteria.
Diagnostic
performance
synthesized
narratively.
Results
In
a
comprehensive
analysis
158
included
studies
evaluating
AI
algorithms
noninvasive
across
8
major
human
system
cancers,
accuracy
classifiers
central
nervous
cancers
varied
widely
(ranging
48%
100%).
Similarities
observed
diagnostic
head
neck,
respiratory
system,
digestive
urinary
female-related
systems,
skin,
other
sites.
Most
meta-analyses
demonstrated
positive
summary
performance.
For
instance,
9
meta-analyzed
sensitivity
specificity
esophageal
cancer,
showing
ranges
90%-95%
80%-93.8%,
respectively.
case
breast
detection,
calculated
pooled
within
75.4%-92%
83%-90.6%,
Four
reported
ovarian
both
75%-94%.
Notably,
lung
was
relatively
low,
primarily
distributed
between
65%
80%.
Furthermore,
80.4%
(127/158)
high
according
JBI
Checklist,
with
remaining
classified
as
medium
quality.
The
GRADE
assessment
indicated
that
overall
moderate
low.
Conclusions
Although
shows
great
achieving
accelerated,
accurate,
more
objective
diagnoses
multiple
there
are
still
hurdles
overcome
before
its
implementation
clinical
settings.
present
findings
highlight
concerted
effort
research
community,
clinicians,
policymakers
is
required
existing
translate
this
into
improved
outcomes
health
care
delivery.
Trial
Registration
PROSPERO
CRD42022364278;
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022364278
Cancers,
Год журнала:
2023,
Номер
15(21), С. 5236 - 5236
Опубликована: Окт. 31, 2023
Lung
cancer
remains
one
of
the
leading
causes
cancer-related
deaths
worldwide,
emphasizing
need
for
improved
diagnostic
and
treatment
approaches.
In
recent
years,
emergence
artificial
intelligence
(AI)
has
sparked
considerable
interest
in
its
potential
role
lung
cancer.
This
review
aims
to
provide
an
overview
current
state
AI
applications
screening,
diagnosis,
treatment.
algorithms
like
machine
learning,
deep
radiomics
have
shown
remarkable
capabilities
detection
characterization
nodules,
thereby
aiding
accurate
screening
diagnosis.
These
systems
can
analyze
various
imaging
modalities,
such
as
low-dose
CT
scans,
PET-CT
imaging,
even
chest
radiographs,
accurately
identifying
suspicious
nodules
facilitating
timely
intervention.
models
exhibited
promise
utilizing
biomarkers
tumor
markers
supplementary
tools,
effectively
enhancing
specificity
accuracy
early
detection.
distinguish
between
benign
malignant
assisting
radiologists
making
more
informed
decisions.
Additionally,
hold
integrate
multiple
modalities
clinical
data,
providing
a
comprehensive
assessment.
By
high-quality
including
patient
demographics,
history,
genetic
profiles,
predict
responses
guide
selection
optimal
therapies.
Notably,
these
success
predicting
likelihood
response
recurrence
following
targeted
therapies
optimizing
radiation
therapy
patients.
Implementing
tools
practice
aid
diagnosis
management
potentially
improve
outcomes,
mortality
morbidity
npj Digital Medicine,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 31, 2025
The
confluence
of
new
technologies
with
artificial
intelligence
(AI)
and
machine
learning
(ML)
analytical
techniques
is
rapidly
advancing
the
field
precision
oncology,
promising
to
improve
diagnostic
approaches
therapeutic
strategies
for
patients
cancer.
By
analyzing
multi-dimensional,
multiomic,
spatial
pathology,
radiomic
data,
these
enable
a
deeper
understanding
intricate
molecular
pathways,
aiding
in
identification
critical
nodes
within
tumor's
biology
optimize
treatment
selection.
applications
AI/ML
oncology
are
extensive
include
generation
synthetic
e.g.,
digital
twins,
order
provide
necessary
information
design
or
expedite
conduct
clinical
trials.
Currently,
many
operational
technical
challenges
exist
related
data
technology,
engineering,
storage;
algorithm
development
structures;
quality
quantity
pipeline;
sharing
generalizability;
incorporation
into
current
workflow
reimbursement
models.
Cancers,
Год журнала:
2024,
Номер
16(3), С. 674 - 674
Опубликована: Фев. 5, 2024
(1)
Background:
Lung
cancer's
high
mortality
due
to
late
diagnosis
highlights
a
need
for
early
detection
strategies.
Artificial
intelligence
(AI)
in
healthcare,
particularly
lung
cancer,
offers
promise
by
analyzing
medical
data
identification
and
personalized
treatment.
This
systematic
review
evaluates
AI's
performance
cancer
detection,
its
techniques,
strengths,
limitations,
comparative
edge
over
traditional
methods.
(2)
Methods:
meta-analysis
followed
the
PRISMA
guidelines
rigorously,
outlining
comprehensive
protocol
employing
tailored
search
strategies
across
diverse
databases.
Two
reviewers
independently
screened
studies
based
on
predefined
criteria,
ensuring
selection
of
high-quality
relevant
role
detection.
The
extraction
key
study
details
metrics,
quality
assessment,
facilitated
robust
analysis
using
R
software
(Version
4.3.0).
process,
depicted
via
flow
diagram,
allowed
meticulous
evaluation
synthesis
findings
this
review.
(3)
Results:
From
1024
records,
39
met
inclusion
showcasing
AI
model
applications
emphasizing
varying
strengths
among
studies.
These
underscore
potential
but
highlight
standardization
amidst
variations.
results
demonstrate
promising
pooled
sensitivity
specificity
0.87,
signifying
accuracy
identifying
true
positives
negatives,
despite
observed
heterogeneity
attributed
parameters.
(4)
Conclusions:
demonstrates
showing
levels
However,
variations
underline
standardized
protocols
fully
leverage
revolutionizing
diagnosis,
ultimately
benefiting
patients
healthcare
professionals.
As
field
progresses,
validated
models
from
large-scale
perspective
will
greatly
benefit
clinical
practice
patient
care
future.
Abstract
Artificial
intelligence
(AI)
is
rapidly
advancing,
yet
its
applications
in
radiology
remain
relatively
nascent.
From
a
spatiotemporal
perspective,
this
review
examines
the
forces
driving
AI
development
and
integration
with
medicine
radiology,
particular
focus
on
advancements
addressing
major
diseases
that
significantly
threaten
human
health.
Temporally,
advent
of
foundational
model
architectures,
combined
underlying
drivers
development,
accelerating
progress
interventions
their
practical
applications.
Spatially,
discussion
explores
potential
evolving
methodologies
to
strengthen
interdisciplinary
within
medicine,
emphasizing
four
critical
points
imaging
process,
as
well
application
disease
management,
including
emergence
commercial
products.
Additionally,
current
utilization
deep
learning
reviewed,
future
through
multimodal
foundation
models
Generative
Pre‐trained
Transformer
are
anticipated.
Heliyon,
Год журнала:
2024,
Номер
10(2), С. e24665 - e24665
Опубликована: Янв. 1, 2024
Due
to
the
rapid
advancement
of
technology,
artificial
intelligence
(AI)
has
become
extensively
used
for
diagnosis
and
prognosis
various
diseases,
such
as
lung
cancer.
Research
in
field
literature
demonstrated
that
can
be
valuable
timely
detection
cancer
formulation
an
effective
treatment
plan.
This
study
aims
conduct
a
bibliometric
analysis
examine
illustrate
specific
areas
focus,
research
frontiers,
evolutionary
processes,
trends
existing
on
context
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration,
Год журнала:
2024,
Номер
25(5-6), С. 425 - 436
Опубликована: Апрель 2, 2024
Amyotrophic
lateral
sclerosis
(ALS)
is
a
rare
and
fatal
neurological
disease
that
leads
to
progressive
motor
function
degeneration.
Diagnosing
ALS
challenging
due
the
absence
of
specific
detection
test.
The
use
artificial
intelligence
(AI)
can
assist
in
investigation
treatment
ALS.
European Radiology,
Год журнала:
2024,
Номер
34(11), С. 7397 - 7407
Опубликована: Май 22, 2024
Abstract
Purpose
To
compare
the
diagnostic
performance
of
standalone
deep
learning
(DL)
algorithms
and
human
experts
in
lung
cancer
detection
on
chest
computed
tomography
(CT)
scans.
Materials
methods
This
study
searched
for
studies
PubMed,
Embase,
Web
Science
from
their
inception
until
November
2023.
We
focused
adult
patients
compared
efficacy
DL
expert
radiologists
disease
diagnosis
CT
Quality
assessment
was
performed
using
QUADAS-2,
QUADAS-C,
CLAIM.
Bivariate
random-effects
subgroup
analyses
were
tasks
(malignancy
classification
vs
invasiveness
classification),
imaging
modalities
(CT
low-dose
[LDCT]
high-resolution
CT),
region,
software
used,
publication
year.
Results
included
20
various
aspects
Quantitatively,
exhibited
superior
sensitivity
(82%)
specificity
(75%)
to
(sensitivity
81%,
69%).
However,
difference
statistically
significant,
whereas
not
significant.
The
algorithms’
varied
across
different
tasks,
demonstrating
need
tailored
optimization
algorithms.
Notably,
matched
standard
CT,
surpassing
them
specificity,
but
showed
higher
with
lower
LDCT
Conclusion
demonstrated
improved
accuracy
over
readers
malignancy
varies
by
modality,
underlining
importance
continued
research
fully
assess
effectiveness
cancer.
Clinical
relevance
statement
have
potential
refine
matching
specificity.
These
findings
call
further
modalities,
aiming
advance
clinical
diagnostics
patient
outcomes.
Key
Points
Lung
is
challenging
can
be
AI
integration
.
shows
than
Enhanced
could
lead
outcomes
Pharmaceutics,
Год журнала:
2023,
Номер
15(8), С. 2061 - 2061
Опубликована: Июль 31, 2023
Lung
cancer
is
a
major
public
health
problem
and
leading
cause
of
cancer-related
deaths
worldwide.
Despite
advances
in
treatment
options,
the
five-year
survival
rate
for
lung
patients
remains
low,
emphasizing
urgent
need
innovative
diagnostic
therapeutic
strategies.
MicroRNAs
(miRNAs)
have
emerged
as
potential
biomarkers
targets
due
to
their
crucial
roles
regulating
cell
proliferation,
differentiation,
apoptosis.
For
example,
miR-34a
miR-150,
once
delivered
via
liposomes
or
nanoparticles,
can
inhibit
tumor
growth
by
downregulating
critical
promoting
genes.
Conversely,
miR-21
miR-155,
frequently
overexpressed
cancer,
are
associated
with
increased
invasion,
chemotherapy
resistance.
In
this
review,
we
summarize
current
knowledge
miRNAs
carcinogenesis,
especially
those
induced
exposure
environmental
pollutants,
namely,
arsenic
benzopyrene,
which
account
up
1/10
cases.
We
then
discuss
recent
miRNA-based
therapeutics
diagnostics.
Such
information
will
provide
new
insights
into
pathogenesis
modalities
based
on
miRNAs.