Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance

mBio, Год журнала: 2020, Номер 11(5)

Опубликована: Окт. 5, 2020

The landscape of infectious fungal agents includes previously unidentified or rare pathogens with the potential to cause unprecedented casualties in biodiversity, food security, and human health. influences activity, including crisis climate change, along globalized transport, are underlying factors shaping adaptation increased temperature expanded geographical regions. Furthermore, emergence novel antifungal-resistant strains linked excessive use antifungals (in clinic) fungicides field) offers an additional challenge protect major crop staples control dangerous outbreaks. Hence, alarming frequency infections medical agricultural settings requires effective research understand virulent nature improve outcome infection susceptible hosts. Mycology-driven has benefited from a contemporary unified approach omics technology, deepening biological, biochemical, biophysical understanding these emerging pathogens. Here, we review current state-of-the-art multi-omics technologies, explore power data integration strategies, highlight discovery-based revelations globally important taxonomically diverse This information provides new insight for through in-depth well-characterized fungi alternative therapeutic strategies defined findings virulence, adaptation, resistance.

Язык: Английский

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Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches

Microbes and Infection, Год журнала: 2019, Номер 21(5-6), С. 237 - 245

Опубликована: Июнь 1, 2019

Язык: Английский

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How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts

Journal of Molecular Biology, Год журнала: 2019, Номер 431(16), С. 2982 - 3009

Опубликована: Май 9, 2019

Язык: Английский

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The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi

Annual Review of Genetics, Год журнала: 2019, Номер 53(1), С. 417 - 444

Опубликована: Сен. 20, 2019

species utilize a variety of sexual reproduction mechanisms, which generate genetic diversity, purge deleterious mutations, and contribute to their ability occupy myriad environmental niches exhibit range pathogenic potential. The bisexual unisexual cycles

Язык: Английский

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Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection

Current Biology, Год журнала: 2020, Номер 30(8), С. 1387 - 1396.e5

Опубликована: Фев. 27, 2020

Язык: Английский

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