Journal of Fungi,
Год журнала:
2025,
Номер
11(1), С. 43 - 43
Опубликована: Янв. 7, 2025
Palm
trees
(Arecaceae)
are
among
the
most
popular
ornamental
plants
worldwide.
Despite
extensive
research
on
fungi
associated
with
Arecaceae,
diversity
and
ecological
dynamics
of
affecting
palms
remain
poorly
studied,
although
they
have
significant
impact
palm
health
economic
value.
Furthermore,
while
fungal
has
traditionally
focused
tropical
assemblages,
in
temperate
climates
offer
a
unique
opportunity
to
explore
non-native
habitats.
The
present
study
conducted
preliminary
assessment
ecology
potential
phytopathogenic
foliar
lesions
various
host
species
Portugal,
combining
morphological
examination,
PCR-based
genomic
fingerprinting,
biodiversity
data
analysis.
examination
134
sampled
from
100
resulted
collection
2064
leaf
spotting
(PLSF),
representing
diverse
assemblage
320
molecular
operational
taxonomic
units
(MOTUs)
across
97
genera.
overall
community
composition
revealed
distinct
dominated
by
Neosetophoma,
Alternaria,
Phoma,
Cladosporium,
profusion
infrequent
rare
taxa
consistent
logseries
distribution.
Significantly
positive
co-occurrence
(CO)
patterns
prevalent
uncommon
suggest
synergistic
interactions
enhancing
colonisation,
persistence,
pathogenicity.
structures
PLSF
contrasted
markedly
fungi,
especially
prevalence
pleosporalean
coelomycetes
Didymellaceae
Phaeosphaeriaceae,
including
recently
introduced
or
not
previously
documented
genera
Arecaceae.
This
novel
suggests
that
climatic
constraints
shape
structure
communities,
resulting
distinctive
assemblages.
In
addition,
assemblages
varied
significantly
species,
temperate-native
hosting
more
diverse,
coelomycete-enriched
communities.
findings
highlight
as
hyperdiverse
microhabitats
harbouring
communities
intricate
complex
interplay
climatic,
host,
factors.
With
climate
change
altering
environmental
conditions,
identification
thriving
inhabiting
these
becomes
crucial
for
predicting
shifts
pathogen
mitigating
future
disease
outbreaks.
Understanding
is
essential
identifying
threats
developing
effective
management
strategies
sustainability
plants.
Journal of Fungi,
Год журнала:
2024,
Номер
10(7), С. 447 - 447
Опубликована: Июнь 26, 2024
Invasive
fungal
diseases
(IFDs)
comprise
a
growing
healthcare
burden,
especially
given
the
expanding
population
of
immunocompromised
hosts.
Early
diagnosis
IFDs
is
required
to
optimise
therapy
with
antifungals,
in
setting
rising
rates
antifungal
resistance.
Molecular
techniques
including
nucleic
acid
amplification
tests
and
whole
genome
sequencing
have
potential
offer
utility
overcoming
limitations
traditional
phenotypic
testing.
However,
standardisation
methodology
interpretations
these
assays
an
ongoing
undertaking.
The
targeted
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(9)
Опубликована: Янв. 1, 2024
Abstract
Echinocandins
are
a
class
of
antifungal
drugs
that
inhibit
the
activity
β‐(1,3)‐glucan
synthase
complex,
which
synthesizes
fungal
cell
wall
β‐(1,3)‐glucan.
Echinocandin
resistance
is
linked
to
mutations
in
FKS
gene,
encodes
catalytic
subunit
glucan
complex.
We
present
molecular‐docking‐based
model
provides
insight
into
how
echinocandins
interact
with
target
Fks
protein:
form
ternary
complex
both
and
membrane
lipids.
used
reductive
dehydration
alcohols
generate
dehydroxylated
echinocandin
derivatives
evaluated
their
potency
against
panel
Candida
pathogens
constructed
by
introducing
resistance‐conferring
gene.
found
removing
hemiaminal
alcohol,
drives
significant
conformational
alterations
modified
echinocandins,
reduced
efficacy.
Conversely,
eliminating
benzylic
alcohol
enhanced
up
two
orders
magnitude,
manner
dependent
upon
mutation.
Strains
have
developed
either
rezafungin,
most
recently
clinically
approved
echinocandin,
or
its
derivative
RZF‐1,
exhibit
high
rezafungin
while
demonstrating
moderate
RZF‐1.
These
findings
provide
valuable
for
combating
through
chemical
modifications.
The Lancet Global Health,
Год журнала:
2024,
Номер
12(9), С. e1552 - e1559
Опубликована: Авг. 14, 2024
Amphotericin
B
has
long
been
crucial
for
treating
many
serious
infectious
diseases,
such
as
invasive
fungal
infections
and
visceral
leishmaniasis,
particularly
patients
who
are
immunocompromised,
including
those
with
advanced
HIV
infection.
The
conventional
amphotericin
deoxycholate
formulation
largely
replaced
in
high-income
countries
liposomal
(LAmB),
which
advantages,
lower
rates
of
adverse
events,
nephrotoxicity
anaemia.
Despite
an
evident
need
LAmB
low-income
middle-income
countries,
where
mortality
from
is
still
substantial,
often
use
the
because
a
small
number
generic
formulations
high
price
originator
LAmB.
pricing
also
highly
variable
between
countries.
Overcoming
supply
barriers
through
availability
additional
quality-assured,
at
accessible
prices
would
substantially
facilitate
equitable
access
have
substantial
effect
on
attributable
to
deadly
infections.
Current Opinion in Microbiology,
Год журнала:
2024,
Номер
81, С. 102526 - 102526
Опубликована: Авг. 24, 2024
Fungal
effector
proteins
function
at
the
interfaces
of
diverse
interactions
between
fungi
and
their
plant
animal
hosts,
facilitating
that
are
pathogenic
or
mutualistic.
Recent
advancements
in
protein
structure
prediction
have
significantly
accelerated
identification
functional
predictions
these
rapidly
evolving
proteins.
This
development
enables
scientists
to
generate
testable
hypotheses
for
validation
using
experimental
approaches.
Research
frontiers
biology
include
understanding
pathways
through
which
secreted
translocated
into
host
cells,
roles
manipulating
microbiomes,
contribution
interacting
with
immunity.
Comparative
repertoires
among
different
fungal-host
can
highlight
unique
adaptations,
providing
insights
novel
antifungal
therapies
biocontrol
strategies.
Journal of Fungi,
Год журнала:
2025,
Номер
11(1), С. 43 - 43
Опубликована: Янв. 7, 2025
Palm
trees
(Arecaceae)
are
among
the
most
popular
ornamental
plants
worldwide.
Despite
extensive
research
on
fungi
associated
with
Arecaceae,
diversity
and
ecological
dynamics
of
affecting
palms
remain
poorly
studied,
although
they
have
significant
impact
palm
health
economic
value.
Furthermore,
while
fungal
has
traditionally
focused
tropical
assemblages,
in
temperate
climates
offer
a
unique
opportunity
to
explore
non-native
habitats.
The
present
study
conducted
preliminary
assessment
ecology
potential
phytopathogenic
foliar
lesions
various
host
species
Portugal,
combining
morphological
examination,
PCR-based
genomic
fingerprinting,
biodiversity
data
analysis.
examination
134
sampled
from
100
resulted
collection
2064
leaf
spotting
(PLSF),
representing
diverse
assemblage
320
molecular
operational
taxonomic
units
(MOTUs)
across
97
genera.
overall
community
composition
revealed
distinct
dominated
by
Neosetophoma,
Alternaria,
Phoma,
Cladosporium,
profusion
infrequent
rare
taxa
consistent
logseries
distribution.
Significantly
positive
co-occurrence
(CO)
patterns
prevalent
uncommon
suggest
synergistic
interactions
enhancing
colonisation,
persistence,
pathogenicity.
structures
PLSF
contrasted
markedly
fungi,
especially
prevalence
pleosporalean
coelomycetes
Didymellaceae
Phaeosphaeriaceae,
including
recently
introduced
or
not
previously
documented
genera
Arecaceae.
This
novel
suggests
that
climatic
constraints
shape
structure
communities,
resulting
distinctive
assemblages.
In
addition,
assemblages
varied
significantly
species,
temperate-native
hosting
more
diverse,
coelomycete-enriched
communities.
findings
highlight
as
hyperdiverse
microhabitats
harbouring
communities
intricate
complex
interplay
climatic,
host,
factors.
With
climate
change
altering
environmental
conditions,
identification
thriving
inhabiting
these
becomes
crucial
for
predicting
shifts
pathogen
mitigating
future
disease
outbreaks.
Understanding
is
essential
identifying
threats
developing
effective
management
strategies
sustainability
plants.
