Journal of Fungi,
Год журнала:
2024,
Номер
10(1), С. 85 - 85
Опубликована: Янв. 22, 2024
Mucormycosis
presents
a
formidable
challenge
to
clinicians
and
researchers.
Animal
models
are
an
essential
part
of
the
effort
decipher
pathogenesis
mucormycosis
develop
novel
pharmacotherapeutics
against
it.
Diverse
model
systems
have
been
established,
using
range
animal
hosts,
immune
metabolic
perturbations,
infection
routes.
An
understanding
characteristics,
strengths,
drawbacks
these
is
needed
optimize
their
use
for
specific
research
aims.
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 495 - 498
Опубликована: Янв. 1, 2025
Gastrointestinal
mucormycosis
is
one
of
the
most
difficult
forms
disease
to
diagnose
due
its
lack
specific
clinical
features.
It
extremely
rare
observe
gastrointestinal
in
pediatric
acute
leukemia
patients
undergoing
chemotherapy.
In
this
report,
we
describe
a
case
child
with
who
developed
invasive
mucormycosis,
leading
appendiceal
perforation
and
abdominal
wall
infection.
Initially,
surgical
intervention
was
delayed
concerns
over
exacerbating
bone
marrow
suppression,
which
ultimately
resulted
progression
intra-abdominal
However,
after
thorough
debridement
infection
treatment
liposomal
amphotericin
B,
patient
gradually
recovered.
This
highlights
importance
early
complete
infections
abscesses
prevent
further
spread
shorten
course
disease,
improve
outcomes.
Vaccines,
Год журнала:
2023,
Номер
11(3), С. 555 - 555
Опубликована: Фев. 27, 2023
Coronavirus
disease
2019
(COVID-19)
infection
is
currently
a
great
cause
of
concern
for
the
healthcare
sector
around
globe.
SARS-CoV-2
an
RNA
virus
that
causes
serious
associated
with
numerous
adverse
effects
and
multiple
complications
different
organs
systems
during
its
pathogenic
cycle
in
humans.
Individuals
affected
by
COVID-19,
especially
elderly
populations
immunocompromised
people,
are
greatly
vulnerable
to
opportunistic
fungal
pathogens.
Aspergillosis,
invasive
candidiasis,
mucormycosis
widespread
coinfections
COVID-19
patients.
Other
infections
rare
but
exhibiting
increased
incidence
current
scenario
include
caused
Pneumocystis
jirovecii,
Histoplasma
sp.,
Cryptococcus
etc.
By
producing
virulent
spores,
these
pathogens
increase
severity
morbidity
fatality
rates
patients
globally.
These
generally
occur
recovering
from
infection,
resulting
rehospitalization.
Older
individuals
at
higher
risk
developing
infections.
This
review
focuses
on
understanding
prevalent
patients,
people.
We
have
also
highlighted
important
preventive
methods,
diagnostic
approaches,
prophylactic
measures
Journal of Fungi,
Год журнала:
2023,
Номер
9(6), С. 659 - 659
Опубликована: Июнь 12, 2023
Mucormycosis
is
an
uncommon,
yet
deadly
invasive
fungal
infection
caused
by
the
Mucorales
moulds.
These
pathogens
are
a
WHO-assigned
high-priority
pathogen
group,
as
mucormycosis
incidence
increasing,
and
there
unacceptably
high
mortality
with
current
antifungal
therapies.
Current
diagnostic
methods
have
inadequate
sensitivity
specificity
may
issues
accessibility
or
turnaround
time.
Patients
diabetes
mellitus
immune
compromise
predisposed
to
these
environmental
fungi,
but
COVID-19
has
established
itself
new
risk
factor.
also
cause
healthcare-associated
outbreaks,
clusters
associated
natural
disasters
been
identified.
Robust
epidemiological
surveillance
into
burden
of
disease,
at-risk
populations,
emerging
required.
Emerging
serological
molecular
techniques
offer
faster
route
diagnosis,
while
newly
developed
agents
show
promise
in
preliminary
studies.
Equitable
access
therapies
will
be
key
identifying
treating
mucormycosis,
delayed
initiation
therapy
higher
mortality.
Functional Food Science - Online ISSN 2767-3146,
Год журнала:
2023,
Номер
3(7), С. 108 - 108
Опубликована: Июль 14, 2023
Objective:
Phenolic
compounds
are
essential
for
defense
reactions,
including
antioxidant,
anti-inflammatory,
antidiabetic,
anti-proliferative
activity,
and
anti-aging
activity.
Coming
from
the
class
of
phytomedicine,
they
widespread
in
plant
kingdom
commonly
taken
as
substances
daily
diet.
They
mainly
found
various
types
edible
plants,
especially
fruits,
vegetables,
tea.
have
been
investigated
their
effects
on
human
health
due
to
beneficial
against
oxidative
stress
activities.
The
proposed
main
mechanism
this
protective
effect
harmful
oxidation
processes
is
related
radical
scavenging
activity
phenolic
reactive
oxygen
nitrogen
substances.
review
uses
up-to-date
data
via
manual
screening
titles
abstracts
retrieved
articles
using
string
pharmaceutical
medical
benefits
keywords
obtain
publications
electronic
databases
PubMed
Google
Scholar
publish
or
perish
tool.
However,
priority
has
given
scientific
papers,
reports,
literature
issued
within
past
5
years.Several
research
conducted
potential
pharmacological
Dietary
intake
also
associated
with
reducing
risk
cardiovascular
disease,
caused
by
behavioral
factors
such
alcohol
abuse,
tobacco
use,
a
high-fat
diet,
sedentary
lifestyle.
effective
fighting
diseases.Conclusion:
This
article
highlights
currently
available
information
knowledge
compounds.Keywords:
compounds,
flavanoids,
Heart
Antioxidant,
Cancer,
Diabetes
mellitus
Frontiers in Fungal Biology,
Год журнала:
2024,
Номер
5
Опубликована: Апрель 22, 2024
Fungal
diseases
have
emerged
as
a
significant
global
health
threat,
with
the
potential
to
cause
widespread
outbreaks
and
morbidity
mortality.
Anticipating
future
pandemic
fungal
is
essential
for
effective
preparedness
response
strategies.
This
comprehensive
literature
review
aims
provide
analysis
of
existing
research
on
this
topic.
Through
an
extensive
examination
scholarly
articles,
identifies
pathogens
that
become
pandemics
in
future.
It
explores
factors
contributing
emergence
spread
these
diseases,
including
climate
change,
globalization,
antimicrobial
resistance.
The
also
discusses
challenges
diagnosing
treating
limited
access
diagnostic
tools
antifungal
therapies.
Furthermore,
it
examines
strategies
interventions
can
be
employed
mitigate
impact
such
improved
surveillance
systems,
public
education,
advancements.
findings
contribute
our
understanding
risks
posed
by
valuable
insights
professionals
policymakers
effectively
preparing
responding
outbreaks.
Overall,
emphasizes
importance
proactive
measures
collaborative
efforts
anticipate
diseases.
BMC Infectious Diseases,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 6, 2025
Mucormycosis
is
an
opportunistic
fungal
infection
which
associated
with
poor
prognosis.
Only
a
few
antifungals
are
available
in
the
arsenal
against
mucormycosis.
The
global
guidelines
for
diagnosing
and
managing
mucormycosis
recommend
high
doses
of
liposomal
amphotericin
B
(LAmB)
as
first-line
treatment.
Isavuconazole
another
potential
treatment
option
This
systematic
review
aims
to
consolidate
analyse
existing
evidence
concerning
efficacy
safety
isavuconazole
treating
alone
or
combination
LAmB.
For
data
aggregation,
comprehensive
searches
were
conducted
across
various
electronic
databases,
such
PubMed,
Science
Direct,
Trip,
Google
Scholar,
Cochrane
Library,
Open-Gray.
Furthermore,
we
explored
gray
literature,
employing
tailored
keywords.
reference
lists
selected
articles
scrutinized
identify
additional
pertinent
publications.
Articles
reporting
any
studies,
case
series,
reports
on
form
exclusively
involving
human
subjects
published
English
included.
There
no
time
restrictions
involved.
We
extracted
crucial
data,
publication
year,
country,
disease
form,
dosage,
frequency,
duration,
overall
outcomes,
reported
adverse
effects.
A
total
31
articles,
included
four
24
reports,
one
open-label
trial,
randomized
controlled
non-interventional
registry
study,
final
analysis.
135
adult
patients
14
children
treated
primary
monotherapy,
therapy,
nonprimary
therapy.
mortality
rate
following
LAmB
plus
azole,
followed
posaconazole
only
was
32%,
6.6%,
13.7%,
17.2%
24.6%,
respectively.
heterogeneity
studies
did
not
allow
comparison
different
strategies
(primary
mono-
vs.
combination,
etc.).
use
therapies
during
acute
phase
via
intravenous
administration
alongside
other
triazoles,
by
long-term
monotherapy
oral
route,
has
yielded
promising
recovery
rates.
Adverse
events
infrequently
reported.
International Journal of Otorhinolaryngology and Head and Neck Surgery,
Год журнала:
2025,
Номер
11(1), С. 71 - 74
Опубликована: Янв. 27, 2025
The
successful
treatment
of
mucormycosis
requires;
early
diagnosis;
reversal
underlying
predisposing
risk
factors,
if
possible,
surgical
debridement,
where
applicable
and
prompt
antifungal
therapy.
Amphotericin
B
is
the
gold
standard
against
to
date.
However,
there
are
newer
agents
described
recently
like
posaconazole
isavuconazole
which
can
be
used
as
an
option
in
a
few
instances.
Although
amphotericin
especially
liposomal
preparation
preferred
agent,
availability
cost
limit
its
use,
resource-limited
setups.
Generally,
azole
drugs,
first
generations
such
fluconazole,
not
effective
zygomycetes.
reports
showed
complete
recovery
after
use
fluconazole
for
adjunct
treatment.
Here
we
report
on
35-year-old
newly
diagnosed
diabetic
woman
with
Sinoorbital
who
has
been
treated
debridement
intermittent
bases
was
discharged
home
without
optimal
response
but
returned
completely
improved
three
months
oral
fluconazole.
