Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis DOI

Mansi Tanwar,

Anamika Singh, T.P. Singh

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1431 - 1457

Published: April 29, 2024

Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, crowded settings. Major contributing factors include diabetes weakened immune systems. main manifesting forms of CAM─cutaneous, pulmonary, deadliest, rhinocerebral─and disseminated infections elevated mortality rates 85%. Recent focus lies on small-molecule inhibitors due their advantages over standard treatments like surgery liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, simpler dosing owing small size, rendering ability traverse blood–brain barrier via passive diffusion facilitated by phospholipid membrane. Adaptation versatility mucormycosis are multitude virulence factors, enabling pathogen dynamically respond various environmental stressors. A comprehensive understanding these mechanisms imperative for devising effective therapeutic interventions against this highly opportunistic that thrives immunocompromised individuals through its angio-invasive nature. Hence, Review delineates principal it employs persist challenging host environments, current progress developing them.

Language: Английский

Mucormycosis Infection in Lung Transplant Patients: Experience in Andalusia, Spain DOI
Alba María Fernández, Nicola Di Lorenzo,

Benito Cantador Huertos

et al.

Transplantation Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Appendiceal Perforation and Abdominal Wall Infection Caused by Invasive Mucormycosis in a Child with Acute Leukemia DOI Creative Commons
Chunyang Li,

Yonghan Luo,

Yanchun Wang

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 495 - 498

Published: Jan. 1, 2025

Gastrointestinal mucormycosis is one of the most difficult forms disease to diagnose due its lack specific clinical features. It extremely rare observe gastrointestinal in pediatric acute leukemia patients undergoing chemotherapy. In this report, we describe a case child with who developed invasive mucormycosis, leading appendiceal perforation and abdominal wall infection. Initially, surgical intervention was delayed concerns over exacerbating bone marrow suppression, which ultimately resulted progression intra-abdominal However, after thorough debridement infection treatment liposomal amphotericin B, patient gradually recovered. This highlights importance early complete infections abscesses prevent further spread shorten course disease, improve outcomes.

Language: Английский

Citations

1
Post-COVID-19 Fungal Infection in the Aged Population DOI Creative Commons
Vivek P. Chavda, Toshika Mishra, Sathvika Kamaraj

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 555 - 555

Published: Feb. 27, 2023

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around globe. SARS-CoV-2 an RNA virus that causes serious associated with numerous adverse effects and multiple complications different organs systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, mucormycosis widespread coinfections COVID-19 patients. Other infections rare but exhibiting increased incidence current scenario include caused Pneumocystis jirovecii, Histoplasma sp., Cryptococcus etc. By producing virulent spores, these pathogens increase severity morbidity fatality rates patients globally. These generally occur recovering from infection, resulting rehospitalization. Older individuals at higher risk developing infections. This review focuses on understanding prevalent patients, people. We have also highlighted important preventive methods, diagnostic approaches, prophylactic measures

Language: Английский

Citations

15
Epidemiology, Modern Diagnostics, and the Management of Mucorales Infections DOI Creative Commons
David Pham, Annaleise R. Howard‐Jones,

Rebecca Sparks

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(6), P. 659 - 659

Published: June 12, 2023

Mucormycosis is an uncommon, yet deadly invasive fungal infection caused by the Mucorales moulds. These pathogens are a WHO-assigned high-priority pathogen group, as mucormycosis incidence increasing, and there unacceptably high mortality with current antifungal therapies. Current diagnostic methods have inadequate sensitivity specificity may issues accessibility or turnaround time. Patients diabetes mellitus immune compromise predisposed to these environmental fungi, but COVID-19 has established itself new risk factor. also cause healthcare-associated outbreaks, clusters associated natural disasters been identified. Robust epidemiological surveillance into burden of disease, at-risk populations, emerging required. Emerging serological molecular techniques offer faster route diagnosis, while newly developed agents show promise in preliminary studies. Equitable access therapies will be key identifying treating mucormycosis, delayed initiation therapy higher mortality.

Language: Английский

Citations

15
Selected potential pharmaceutical and medical benefits of phenolic compounds: Recent advances DOI Open Access

M. Abd Elgadir,

Sridevi Chigurupati, Abdalbasit Adam Mariod

et al.

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2023, Volume and Issue: 3(7), P. 108 - 108

Published: July 14, 2023

Objective: Phenolic compounds are essential for defense reactions, including antioxidant, anti-inflammatory, antidiabetic, anti-proliferative activity, and anti-aging activity. Coming from the class of phytomedicine, they widespread in plant kingdom commonly taken as substances daily diet. They mainly found various types edible plants, especially fruits, vegetables, tea. have been investigated their effects on human health due to beneficial against oxidative stress activities. The proposed main mechanism this protective effect harmful oxidation processes is related radical scavenging activity phenolic reactive oxygen nitrogen substances. review uses up-to-date data via manual screening titles abstracts retrieved articles using string pharmaceutical medical benefits keywords obtain publications electronic databases PubMed Google Scholar publish or perish tool. However, priority has given scientific papers, reports, literature issued within past 5 years.Several research conducted potential pharmacological Dietary intake also associated with reducing risk cardiovascular disease, caused by behavioral factors such alcohol abuse, tobacco use, a high-fat diet, sedentary lifestyle. effective fighting diseases.Conclusion: This article highlights currently available information knowledge compounds.Keywords: compounds, flavanoids, Heart Antioxidant, Cancer, Diabetes mellitus

Language: Английский

Citations

11
Unveiling the menace: a thorough review of potential pandemic fungal disease DOI Creative Commons
Mahdi Jafarlou

Frontiers in Fungal Biology, Journal Year: 2024, Volume and Issue: 5

Published: April 22, 2024

Fungal diseases have emerged as a significant global health threat, with the potential to cause widespread outbreaks and morbidity mortality. Anticipating future pandemic fungal is essential for effective preparedness response strategies. This comprehensive literature review aims provide analysis of existing research on this topic. Through an extensive examination scholarly articles, identifies pathogens that become pandemics in future. It explores factors contributing emergence spread these diseases, including climate change, globalization, antimicrobial resistance. The also discusses challenges diagnosing treating limited access diagnostic tools antifungal therapies. Furthermore, it examines strategies interventions can be employed mitigate impact such improved surveillance systems, public education, advancements. findings contribute our understanding risks posed by valuable insights professionals policymakers effectively preparing responding outbreaks. Overall, emphasizes importance proactive measures collaborative efforts anticipate diseases.

Language: Английский

Citations

4
Rhino-orbital cerebral mucormycosis DOI Creative Commons

Arlene Campos,

Rebecca Hong

Radiopaedia.org, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

Citations

3
Use of isavuconazole in mucormycosis: a systematic review DOI Creative Commons
Shobha Gunathilaka,

Reshani Kaumada Keragala,

Kalpani Lakmali Gunathilaka

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Mucormycosis is an opportunistic fungal infection which associated with poor prognosis. Only a few antifungals are available in the arsenal against mucormycosis. The global guidelines for diagnosing and managing mucormycosis recommend high doses of liposomal amphotericin B (LAmB) as first-line treatment. Isavuconazole another potential treatment option This systematic review aims to consolidate analyse existing evidence concerning efficacy safety isavuconazole treating alone or combination LAmB. For data aggregation, comprehensive searches were conducted across various electronic databases, such PubMed, Science Direct, Trip, Google Scholar, Cochrane Library, Open-Gray. Furthermore, we explored gray literature, employing tailored keywords. reference lists selected articles scrutinized identify additional pertinent publications. Articles reporting any studies, case series, reports on form exclusively involving human subjects published English included. There no time restrictions involved. We extracted crucial data, publication year, country, disease form, dosage, frequency, duration, overall outcomes, reported adverse effects. A total 31 articles, included four 24 reports, one open-label trial, randomized controlled non-interventional registry study, final analysis. 135 adult patients 14 children treated primary monotherapy, therapy, nonprimary therapy. mortality rate following LAmB plus azole, followed posaconazole only was 32%, 6.6%, 13.7%, 17.2% 24.6%, respectively. heterogeneity studies did not allow comparison different strategies (primary mono- vs. combination, etc.). use therapies during acute phase via intravenous administration alongside other triazoles, by long-term monotherapy oral route, has yielded promising recovery rates. Adverse events infrequently reported.

Language: Английский

Citations

0
Sino orbital mucormycosis treated with fluconazole DOI Open Access

Assaye N. Alebachew,

Dawit Kebebaw Dibaba

International Journal of Otorhinolaryngology and Head and Neck Surgery, Journal Year: 2025, Volume and Issue: 11(1), P. 71 - 74

Published: Jan. 27, 2025

The successful treatment of mucormycosis requires; early diagnosis; reversal underlying predisposing risk factors, if possible, surgical debridement, where applicable and prompt antifungal therapy. Amphotericin B is the gold standard against to date. However, there are newer agents described recently like posaconazole isavuconazole which can be used as an option in a few instances. Although amphotericin especially liposomal preparation preferred agent, availability cost limit its use, resource-limited setups. Generally, azole drugs, first generations such fluconazole, not effective zygomycetes. reports showed complete recovery after use fluconazole for adjunct treatment. Here we report on 35-year-old newly diagnosed diabetic woman with Sinoorbital who has been treated debridement intermittent bases was discharged home without optimal response but returned completely improved three months oral fluconazole.

Language: Английский

Citations

0
The Importance of MRI in the Early Diagnosis of Acute Invasive Fungal Rhinosinusitis DOI Creative Commons
François Voruz, Dionysios Neofytos, Christian van Delden

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 311 - 311

Published: Jan. 28, 2025

Acute invasive fungal rhinosinusitis (AIFR) is a rare, severe, and life-threatening opportunistic infection associated with high mortality morbidity. Rapid accurate diagnosis treatment are crucial for survival effective disease management. Diagnosing AIFR challenging because no single pathognomonic feature exists other than surgical biopsy showing angioinvasion necrosis. This narrative review focuses on the diagnostic challenges pitfalls, emphasizing critical clinical value of magnetic resonance imaging (MRI) early AIFR. It includes selected cases that illustrate significance MRI. When suspected, symptoms, nasal endoscopy, blood samples, facial computed tomography all provide non-specific information. In contrast, MRI can identify signs devitalized sinonasal mucosa consistent The absence mucosal enhancement T1-weighted images, combined restricted diffusivity, characteristic features presented underscore usefulness in supporting suspicion accurately determining its topography, thereby guiding biopsies debridement. suspected AIFR, serves as valuable supplementary, non-invasive tool to help determine whether prompt or debridement necessary, enhancing improving rates. Therefore, threshold conducting an these should be low.

Language: Английский

Citations

0