Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice DOI Open Access
Juhi Shah,

Tyler Orosz,

Avneet Singh

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9019 - 9019

Опубликована: Авг. 20, 2024

The prevalence of obesity and related consequences, including insulin resistance Alzheimer's-like neuropathology, has increased dramatically. Contributing to this is the shift in lifestyle preference away from wholesome foods exercise Western-style diet sedentarism. Despite advances drug development, a healthy regular remain most effective approaches mitigating unwanted sequelae diet-induced on brain health. In study, we used high-fat high-sugar (HFHS) mouse model neurodegeneration examine effects training (HFHS+Ex), genistein treatment (HFHS+Gen), combination (HFHS+Ex+Gen) proteins relating male mice. After period 12 weeks, as expected, HFHS feeding body weight, adipose tissue systemic plasma inflammation (TNF-α) compared lean mice fed standard diet. also protein expression markers (pGSK-3β, p-IR), apoptosis (caspase 3), early neurofibrillary tangles (CP13), amyloid-beta precursor (CT20). Compared mice, Ex decreased TNF-α, pGSK-3β, caspase 3, CP13, amyloid-β (22c11), ADAM10. Treatment with Gen was equally protective these p-IR. Combination afforded greatest overall benefits, group exhibited reduction weight all markers, except for 22c11 ADAM10, which were an addition, levels 4G8, detects amyloid-β, treatment. Our results indicate that training, supplementation, or provide varying degrees neuroprotection feeding-induced Alzheimer's pathology. Future perspectives could include evaluating moderate regimens dietary supplementation humans determine whether same benefits translate clinically.

Язык: Английский

Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review DOI Creative Commons
Claudie Hooper, Nicola Coley, Julien Delrieu

и другие.

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100130 - 100130

Опубликована: Март 1, 2025

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as minimally invasive tool for detection monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, social isolation) plasma of AD: Aβ42, Aβ40, Aβ42/40, phosphorylated tau, total neurofilament light chain (NfL) glial fibrillary acidic protein. Limited evidence suggests that better nutrition associated with favourable AD biomarker profiles PA less NfL Aβ, whilst poor sleep elevated Aβ. However, lack data inconsistent findings highlight need further investigation to substantiate or refute these trends. Moreover, future research should include analysis on according gender, metabolic health APOE status. Considering growing emphasis preventing delaying dementia onset justified.

Язык: Английский

Процитировано

0
Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice DOI Open Access
Juhi Shah,

Tyler Orosz,

Avneet Singh

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9019 - 9019

Опубликована: Авг. 20, 2024

The prevalence of obesity and related consequences, including insulin resistance Alzheimer's-like neuropathology, has increased dramatically. Contributing to this is the shift in lifestyle preference away from wholesome foods exercise Western-style diet sedentarism. Despite advances drug development, a healthy regular remain most effective approaches mitigating unwanted sequelae diet-induced on brain health. In study, we used high-fat high-sugar (HFHS) mouse model neurodegeneration examine effects training (HFHS+Ex), genistein treatment (HFHS+Gen), combination (HFHS+Ex+Gen) proteins relating male mice. After period 12 weeks, as expected, HFHS feeding body weight, adipose tissue systemic plasma inflammation (TNF-α) compared lean mice fed standard diet. also protein expression markers (pGSK-3β, p-IR), apoptosis (caspase 3), early neurofibrillary tangles (CP13), amyloid-beta precursor (CT20). Compared mice, Ex decreased TNF-α, pGSK-3β, caspase 3, CP13, amyloid-β (22c11), ADAM10. Treatment with Gen was equally protective these p-IR. Combination afforded greatest overall benefits, group exhibited reduction weight all markers, except for 22c11 ADAM10, which were an addition, levels 4G8, detects amyloid-β, treatment. Our results indicate that training, supplementation, or provide varying degrees neuroprotection feeding-induced Alzheimer's pathology. Future perspectives could include evaluating moderate regimens dietary supplementation humans determine whether same benefits translate clinically.

Язык: Английский

Процитировано

2