Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2
Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 113 - 113
Опубликована: Янв. 13, 2025
Nuclear
factor
erythroid
2-related
2
(NRF2)
is
a
master
regulator
of
cellular
homeostasis,
overseeing
the
expression
wide
array
genes
involved
in
cytoprotective
processes
such
as
antioxidant
and
proteostasis
control,
mitochondrial
function,
inflammation,
metabolism
lipids
glucose.
The
accumulation
misfolded
proteins
triggers
release,
stabilization,
nuclear
translocation
NRF2,
which
turn
enhances
critical
components
both
proteasomal
lysosomal
degradation
pathways.
This
process
facilitates
clearance
toxic
protein
aggregates,
thereby
actively
maintaining
proteostasis.
As
we
age,
efficiency
NRF2
pathway
declines
due
to
several
factors
including
increased
activity
its
repressors,
impaired
NRF2-mediated
gene
expression,
potential
epigenetic
changes,
though
precise
mechanisms
remain
unclear.
leads
diminished
defenses,
oxidative
damage,
exacerbated
metabolic
dysregulation
inflammation—key
contributors
age-related
diseases.
Given
NRF2’s
role
mitigating
proteotoxic
stress,
pharmacological
modulation
has
emerged
promising
therapeutic
strategy,
even
aged
preclinical
models.
By
inducing
it
possible
mitigate
damaging
effects
dysfunction,
thus
reducing
misfolding.
review
highlights
implications
for
neurodegenerative
diseases
cardiovascular
conditions,
emphasizing
improving
redox
homeostasis
Additionally,
summarizes
current
research
into
target,
offering
hope
innovative
treatments
counteract
aging
associated
Язык: Английский
The Beneficial Effects of Combined Exercise and Polyphenols in Alzheimer's Disease
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Regular
exercise
enhances
life
quality,
lowers
the
risk
of
cognitive
damage,
and
slows
advancement
Alzheimer's
disease
(AD).
Natural
compounds
rich
in
polyphenols
have
garnered
attention
as
a
non-pharmacological
means
treating
preventing
AD.
The
primary
component
wine,
grape
seeds,
nuts
is
polyphenols.
Research
suggests
that
slow
down
rate
neurodegeneration
AD
lessen
learning
impairment.
Furthermore,
brain
impairments
related
to
cognition.
Additionally,
can
specifically
restructure
amyloid-β
(Aβ)
structures
soluble
oligomers
into
non-toxic
alternative
species.
They
also
been
revealed
increase
brain-derived
neurotrophic
factors
expression,
suggesting
they
positive
impact
on
creation
neurotrophins.
benefits
polyphenol
supplementation
exercise,
which
both
provide
neuroprotection,
not
well
studied
patients.
This
review
aimed
investigate
effects
combined
inflammation,
several
conformational
toxic
species
Aβ,
Aβ-induced
apoptosis
Язык: Английский