Demographics and clinical characteristics of a new population of centenarians in Colombia. The COOLCEN cohort

Archives of Gerontology and Geriatrics Plus, Год журнала: 2024, Номер 1(1), С. 100006 - 100006

Опубликована: Янв. 8, 2024

Centenarians represent a successful model of biological aging that is becoming increasingly common but still largely unknown. Data about centenarians in Colombia scarce. The aim this study was to provide description the demographic and clinical characteristics new cohort Colombia. A retrospective, population-based undertaken, employing nationally validated registry provided by health insurance company. Demographic information prevalence rates significant chronic diseases were evaluated. geographical distribution at national level mapped. then compared with other age groups (>18-59 60-99 years-old), previous descriptions centenarians. Among 2,362,436 persons included study, 0.12% observed, which 50.7% female majority resides urban areas (64.9%). Chronic observed 275 (9.27%) centenarians, whom 113 (3.81%) disclosed one disease 162 (5.46%) multimorbidity. most prevalent essential hypertension (8.6%), kidney (4.4%), significantly lower others groups. free hematological, inflammatory arthritis, tuberculosis human immunodeficiency virus infections. COVID-19 2% cases. Significant differences outcomes assessed seen when comparing our results from previously described blue zones. COOLCEN discloses low age-related diseases, economic status no difference gender distribution. will valuable insights into healthy aging, prevention, improving well-being older adults.

Язык: Английский

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Autoimmunity in centenarians. A paradox

Journal of Translational Autoimmunity, Год журнала: 2024, Номер 8, С. 100237 - 100237

Опубликована: Март 2, 2024

Autoimmune diseases (ADs) are one of the groups chronic illnesses that impose a significant burden disease and health costs worldwide. Age is crucial risk factor for onset ADs. Theoretically, it inferred with organic immune system aging, loss tolerance specificity activity becomes more intense, probability autoimmunity increasing. However, there group individuals whose prevalence ADs very low or non-existent, despite biological aging. This paradox in raises questions. Centenarians, who over 100 years old, possibly most successful model aging humans. Most these exhibit favorable phenotype. To date, primary data evidence potential hypotheses explaining this phenomenon lacking globally, even though could provide valuable, original, relevant information regarding understanding protective factors, drivers, biomarkers related to autoimmunity. Herein we discuss some hypothesis may explain absence centenarians, including inflammaging, immunosenescence resilience, hyperstimulation, proteodynamics, genetics.

Язык: Английский

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How Important Are Genes to Achieve Longevity?

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5635 - 5635

Опубликована: Май 18, 2022

Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE FOXO3A, involved protection cardiovascular diseases, shown to be associated with nearly all studies. This happens because genetic determinants are dynamic depend environmental history a given population. In fact, population-specific genes thought play greater role attainment than those shared between different populations. Hence, it is not surprising that GWAS replicated associations common variants few, if any, as these pool together An alternative way might study long-life families. type approach proving an ideal resource for uncovering protective alleles biological signatures healthy aging phenotypes exceptional longevity.

Язык: Английский

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Sex and gender affect immune aging

Frontiers in Aging, Год журнала: 2023, Номер 4

Опубликована: Ноя. 28, 2023

The proposed review aims to elucidate the intricate interplay between biological factors (sex differences) and socially constructed (gender in context of immune aging. While influence differences men women on various aspects responses has long been recognized, it is crucial acknowledge that gender, encompassing social cultural roles expectations associated with being male or female, also significantly shapes these processes. Gender can either accelerate aging promote longevity. By recognizing impact both factors, this work seeks offer a comprehensive understanding why may experience divergent trajectories varying outcomes terms Discrepancies perceived sexes, within families at work, contribute differing patterns antigen exposure. Additionally, variations micronutrient intake access preventive healthcare facilities exist. Health promotion knowledge often correlates educational attainment, which unequally represented males females many cultures across generations Western world. In countries without universal system, relies family prioritization strategies cope economic constraints, potentially limiting specific treatments affecting negatively. As result, behavioral gender disparities responses, susceptibility infections, autoimmune diseases, vaccine among older individuals. However, as demonstrated by COVID-19 pandemic, exhibit greater resilience infections than males. Given role system achieving longevity, not surprising live longer men, number female centenarians surpasses centenarians.

Язык: Английский

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Polyunsaturated fatty acid status and markers of oxidative stress and inflammation across the lifespan: A cross-sectional study in a cohort with long-lived individuals

Experimental Gerontology, Год журнала: 2024, Номер 195, С. 112531 - 112531

Опубликована: Июль 31, 2024

Polyunsaturated fatty acids (PUFA) are known to have a regulatory effect on oxidative and inflammatory processes. This study aimed identify the relationship between blood PUFA status circulatory markers of stress inflammation in cohort 172 subjects. The population was divided by sex into three age groups: adults (18-64 years old, n = 69), older (65-89 54), long-lived individuals (LLIs, 90-111 49). Whole content quantified using gas chromatography. Additionally, serum levels C-reactive protein (CRP), paraoxonase (PON), Trolox equivalent antioxidant capacity (TEAC), malondialdehyde (MDA) were measured. Our results showed that higher omega-3 (n-3) index adult females predictor lower MDA concentrations (p 0.038). Conversely, total n-3 n-6 positively related values among LLI men < 0.05), while inversely correlated with 0.05). Interestingly, increased TEAC 0.007), arachidonic acid (AA)/eicosapentaenoic (EPA) ratio 0.006). These findings suggest cellular is changes AA/EPA females, whereas may enhance men. Overall, our highlights complex, sex-specific interactions profiles across different groups.

Язык: Английский

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Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender

Clinical & Experimental Immunology, Год журнала: 2021, Номер 205(2), С. 198 - 212

Опубликована: Апрель 18, 2021

Ageing dramatically affects number and function of both innate adaptive arms immune system, particularly T cell subsets, contributing to reduced vaccination efficacy, decreased resistance infections increased prevalence cancer in older people. In the present paper, we analysed age-related changes absolute lymphocytes 214 Sicilian subjects, percentages natural killer (NK) cells a subcohort donors. We compared these results with immunophenotype oldest living Italian supercentenarian (aged 111 years). The were also sorted by gender. correlation between number/percentage age all individuals. separately males females, was examined using simple linear regression analysis. did not record increase rate inversion CD4/CD8 ratio, frequently reported as being associated ageing literature. Our observation direct consequence flat average trend CD4

Язык: Английский

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Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(16), С. 10180 - 10180

Опубликована: Авг. 17, 2022

Multimorbidity is challenging for both patients and healthcare systems due to its increasing prevalence high impact on people's health well-being. The risk of multimorbidity increases with age, but there still more discover regarding the clinical profile oldest old. In this study, we used information from EpiChron Cohort Study identify patterns in individuals who died during period 2010-2019 at ages 80-89, 90-99, ≥100. This cohort links demographic, clinical, drug dispensation public system users Aragón, Spain. We saw a significantly lower number chronic diseases drugs polypharmacy centenarians compared those aged 80-99. K-means clustering revealed different clusters by sex age group. observed cardiovascular metabolic diseases, obstructive pulmonary conditions, neoplasms, amongst other profiles. One three octogenarian women had pattern (diabetes, dyslipidaemia, endocrine-metabolic disorders) highest (up seven) (64%). dementia genitourinary disorders medication anticholinergic activity. Our study offers an opportunity better understand urgency adequately addressing our older adults.

Язык: Английский

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Sicilian semi- and supercentenarians: identification of age-related T-cell immunophenotype to define longevity trait

Clinical & Experimental Immunology, Год журнала: 2023, Номер 214(1), С. 61 - 78

Опубликована: Июль 1, 2023

Abstract The immunophenotype of oldest centenarians, i.e. semi- and supercentenarians, could provide important information about their ability to adapt factors associated with immune changes, including ageing per se chronic Cytomegalovirus infection. We investigated, by flow cytometry, variations in percentages absolute numbers cell subsets, focusing on T cells, pro-inflammatory parameters a cohort 28 women 26 men (age range 19–110 years). observed variability hallmarks immunosenescence related age serological status. eight centenarians showed the lowest naïve due age, highest T-effector memory cells re-expressing CD45RA (TEMRA), according cytomegalovirus status, high levels serum parameters, although means were lower than that remaining 90+ donors. Some them CD8 TEMRA percentages, exhaustion/pro-inflammatory markers comparable younger ones. Our study supports suggestion ageing, especially exhibits great is not only attributable single contributor but should also be full result combination several factors. Everyone ages differently because he/she unique genetics experience life this applies even more system; everybody has had different immunological history. Furthermore, our findings inflammatory markers, CMV seropositivity discussed light most recent literature, suggest these changes might unfavourable for particular

Язык: Английский

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miR-126-3p and miR-21-5p as Hallmarks of Bio-Positive Ageing; Correlation Analysis and Machine Learning Prediction in Young to Ultra-Centenarian Sicilian Population

Cells, Год журнала: 2022, Номер 11(9), С. 1505 - 1505

Опубликована: Апрель 30, 2022

Human ageing can be characterized by a profile of circulating microRNAs (miRNAs), which are potentially predictors biological age. They used as biomarker risk for age-related inflammatory outcomes, and senescent endothelial cells (ECs) have emerged possible source miRNAs. In this paper, panel four miRNAs including miR-146a-5p, miR-126-3p, miR-21-5p, miR-181a-5p, involved in several pathways related to inflammation, ECs senescence that seem characteristic the healthy phenotype. The levels these were determined 78 subjects aged between 22 111 years. Contextually, extracellular miR-181a-5p measured human vitro model, undergoing senescence. We found miRNAs, using ex vivo models, progressively increase with age, apart from ultra-centenarians showed comparable those young individuals. Our results contribute development knowledge regarding identification biomarkers successful unsuccessful ageing. Indeed, they might diagnostic/prognostic relevance diseases.

Язык: Английский

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Sicilian semi- and supercentenarians: age-related NK cell immunophenotype and longevity trait definition

Translational Medicine UniSa, Год журнала: 2023, Номер 25(1)

Опубликована: Окт. 7, 2023

The immune system of semi- and supercentenarians (i.e., the oldest centenarians) is believed to have peculiar characteristics that enable them reach extreme longevity in a relatively healthy state. Therefore, previous papers, we investigated, through flow cytometry, variations percentages main subsets Tαβ Tγδ cells Sicilian cohort 28 women 26 men (age range 19-110 years), including 11 long-living individuals (>90 years old) 8 centenarians. These investigations suggested some observed immunophenotypic changes may contribute In present study, further characterize immunophenotype centenarians, examined Natural Killer (NK) identified as CD3-CD56 + CD16+ previously described cohort. We found highly significant increase NK cell with age. When stratified by gender, this age was maintained both sexes, higher significance males. Our findings on cells, together obtained results, discussed context literature, suggest these are not unfavourable for ones, supporting hypothesis aging should be considered differential adaptation rather than general alteration. adapted mechanisms allow centenarians successfully adapt history insults achieve remarkable longevity.

Язык: Английский

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