Circulation Research,
Год журнала:
2025,
Номер
136(5), С. 524 - 550
Опубликована: Фев. 27, 2025
Cardiovascular
diseases
(CVDs)
are
experiencing
a
rapid
surge
and
widely
recognized
as
the
leading
cause
of
mortality
in
current
aging
society.
Given
multifactorial
etiology
CVDs,
understanding
intricate
molecular
cellular
mechanisms
is
imperative.
Over
past
2
decades,
many
scientists
have
focused
on
Sirtuins,
family
nicotinamide
adenine
dinucleotide–dependent
deacylases.
Sirtuins
highly
conserved
across
species,
from
yeasts
to
primates,
play
crucial
role
linking
diseases.
participate
nearly
all
key
physiological
pathological
processes,
ranging
embryogenic
development
stress
response
aging.
Abnormal
expression
activity
exist
aging-related
diseases,
while
their
activation
has
shown
efficacy
mitigating
these
(eg,
CVDs).
In
terms
research,
this
field
maintained
fast,
sustained
growth
recent
years,
fundamental
studies
clinical
trials.
review,
we
present
comprehensive,
up-to-date
discussion
biological
functions
roles
regulating
cardiovascular
biology
CVDs.
Furthermore,
highlight
latest
advancements
utilizing
Sirtuin-activating
compounds
dinucleotide
boosters
potential
pharmacological
targets
for
preventing
treating
The
unresolved
issues
field—from
chemicobiological
regulation
Sirtuin-targeted
CVD
investigations—are
also
discussed.
This
timely
review
could
be
critical
updated
knowledge
Sirtuin
CVDs
facilitating
accessibility
Sirtuin-targeting
interventions.
The
triad
of
vascular
impairment,
muscle
atrophy,
and
cognitive
decline
represents
critical
age-related
conditions
that
significantly
impact
health.
Vascular
impairment
disrupts
blood
flow,
precipitating
mass
reduction
seen
in
sarcopenia
the
neuronal
functions
characteristic
neurodegeneration.
Our
limited
understanding
intricate
relationships
within
this
hinders
accurate
diagnosis
effective
treatment
strategies.
This
review
ana-lyzes
interrelated
mechanisms
contribute
to
these
conditions,
with
a
specific
focus
on
ox-idative
stress,
chronic
inflammation,
impaired
nutrient
delivery.
aim
is
understand
common
pathways
involved
suggest
comprehensive
therapeutic
approaches.
dysfunctions
hinder
circulation
transportation
nutrients,
resulting
sar-copenia
characterized
by
atrophy
weakness.
dysfunction
have
negative
physical
function
quality
life.
Neurodegenerative
diseases
exhibit
comparable
pathophysiological
affect
motor
functions.
Preventive
approaches
encompass
lifestyle
adjustments,
addressing
oxidative
in-flammation,
integrated
therapies
improving
muscular
well-being.
Better
links
can
refine
strategies
yield
better
patient
out-comes.
study
emphasizes
complex
interplay
between
dysfunction,
de-generation,
decline,
highlighting
necessity
for
multidisciplinary
ap-proaches.
Advances
domain
promise
improved
diagnostic
accuracy,
more
thera-peutic
options,
enhanced
preventive
measures,
all
contributing
higher
life
elderly
population.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 2096 - 2096
Опубликована: Сен. 13, 2024
The
triad
of
vascular
impairment,
muscle
atrophy,
and
cognitive
decline
represents
critical
age-related
conditions
that
significantly
impact
health.
Vascular
impairment
disrupts
blood
flow,
precipitating
the
mass
reduction
seen
in
sarcopenia
neuronal
function
characteristic
neurodegeneration.
Our
limited
understanding
intricate
relationships
within
this
hinders
accurate
diagnosis
effective
treatment
strategies.
This
review
analyzes
interrelated
mechanisms
contribute
to
these
conditions,
with
a
specific
focus
on
oxidative
stress,
chronic
inflammation,
impaired
nutrient
delivery.
aim
is
understand
common
pathways
involved
suggest
comprehensive
therapeutic
approaches.
dysfunctions
hinder
circulation
transportation
nutrients,
resulting
characterized
by
atrophy
weakness.
dysfunction
have
negative
physical
quality
life.
Neurodegenerative
diseases
exhibit
comparable
pathophysiological
affect
motor
functions.
Preventive
approaches
encompass
lifestyle
adjustments,
addressing
integrated
therapies
improving
muscular
well-being.
Better
links
can
refine
strategies
yield
better
patient
outcomes.
study
emphasizes
complex
interplay
between
dysfunction,
degeneration,
decline,
highlighting
necessity
for
multidisciplinary
Advances
domain
promise
improved
diagnostic
accuracy,
more
options,
enhanced
preventive
measures,
all
contributing
higher
life
elderly
population.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(16), С. 9082 - 9082
Опубликована: Авг. 13, 2022
Cardiovascular
diseases
(CVDs)
are
a
group
of
in
which
the
common
denominator
is
affection
blood
vessels,
heart
tissue,
and
rhythm.
The
genesis
CVD
complex
multifactorial;
therefore,
approaches
often
based
on
multidisciplinary
management
more
than
one
drug
used
to
achieve
optimal
control
risk
factors
(dyslipidemia,
hypertension,
hypertrophy,
oxidative
stress,
endothelial
dysfunction,
inflammation).
In
this
context,
allicin,
sulfur
compound
naturally
derived
from
garlic,
has
shown
beneficial
effects
several
cardiovascular
through
modulation
cellular
mechanisms
signaling
pathways.
Effective
pharmacological
treatments
for
or
its
have
not
been
developed
unknown
clinical
practice.
Thus,
work
aimed
review
allicin
exerts
therapeutic
show
why
it
could
be
option
prevention
treatment
factors.
Aging and Disease,
Год журнала:
2022,
Номер
13(4), С. 1015 - 1015
Опубликована: Янв. 1, 2022
Aging
is
a
key
risk
factor
for
angiogenic
dysfunction
and
cardiovascular
diseases,
including
heart
failure,
hypertension,
atherosclerosis,
diabetes,
stroke.
Members
of
the
NAD
Cells,
Год журнала:
2024,
Номер
13(9), С. 751 - 751
Опубликована: Апрель 26, 2024
Currently,
more
and
people
are
suffering
from
chronic
kidney
disease
(CKD).
It
is
estimated
that
CKD
affects
over
10%
of
the
population
worldwide.
This
a
significant
issue,
as
kidneys
largely
contribute
to
maintaining
homeostasis
by,
among
other
things,
regulating
blood
pressure,
pH
blood,
water-electrolyte
balance
by
eliminating
unnecessary
metabolic
waste
products
blood.
What
more,
this
does
not
show
any
specific
symptoms
at
beginning.
The
development
predisposed
certain
conditions,
such
diabetes
mellitus
or
hypertension.
However,
these
disorders
only
factors
promoting
onset
progression
CKD.
primary
purpose
review
examine
renin-angiotensin-aldosterone
system
(RAAS)
activity,
transforming
growth
factor-β1
(TGF-β1),
vascular
calcification
(VC),
uremic
toxins,
hypertension
in
context
their
impact
on
occurrence
course
We
firmly
believe
deeper
comprehension
cellular
molecular
mechanisms
underlying
can
lead
an
enhanced
understanding
disease.
In
future,
may
result
medications
targeting
involved
decline
function.
Our
paper
unveils
selected
processes
responsible
for
deterioration
renal
filtration
abilities.
International Journal of Molecular Medicine,
Год журнала:
2022,
Номер
50(6)
Опубликована: Окт. 21, 2022
Vascular
calcification
is
commonly
observed
in
chronic
kidney
disease.
The
mechanism
of
how
the
signal
from
endothelial
cells
transmitted
to
vascular
smooth
muscle
(VSMCs)
remains
unknown.
aim
present
study
was
investigate
whether
exosomes
HUVECs
(HUVEC‑Exos)
could
regulate
VSMC
and
its
potential
signaling
pathway.
HUVEC‑Exos
were
isolated
under
no
phosphorus
(NP)
high
(HP)
conditions.
Alizarin
Red
S
staining
calcium
(Ca)
content
analysis
carried
out
detect
VSMCs.
Proteomics
differential
expression
exosomal
proteins.
Protein
mRNA
levels
measured
by
western
blot
reverse
transcription‑quantitative
PCR
(RT‑qPCR).
Exosomes
derived
HP‑HUVECs
promoted
VSMCs,
as
assessed
staining,
alkaline
phosphatase
activity
assays,
Ca
measurements
increased
runt‑related
transcription
factor
2
osteopontin.
Proteomic
detected
upregulation
STAT1
HP‑exosomes
compared
with
NP‑HUVEC‑Exos,
which
also
confirmed
RT‑qPCR.
Inhibition
VSMCs
using
fludarabine
or
knockdown
small
interfering
RNA
alleviated
Furthermore,
lithium
chloride
(Wnt
activator)
reversed
protective
effect
inhibition
on
calcification,
while
Dickkopf‑1
inhibitor)
exerted
opposite
effect,
suggesting
that
activation
Wnt/β‑catenin
pathway
involved
STAT1‑mediated
calcification.
In
conclusion,
results
indicated
HP‑treated
promote
may
be
a
exosomes.
Heliyon,
Год журнала:
2024,
Номер
10(6), С. e28021 - e28021
Опубликована: Март 1, 2024
Vascular
calcification
(VC)
is
an
accurate
risk
factor
and
predictor
of
adverse
cardiovascular
events;
however,
there
currently
no
effective
therapy
to
specifically
prevent
VC
progression.
Capsaicin
(Cap)
a
bioactive
alkaloid
isolated
from
Capsicum
annuum
L.,
traditional
medicinal
edible
plant
that
beneficial
for
preventing
diseases.
However,
the
effect
Cap
on
remains
unclear.
This
study
aimed
explore
effects
related
mechanisms
aortic
in
mouse
Pi-induced
vascular
smooth
muscle
cells
(VSMCs).
First,
we
established
model
with
vitamin
D3
evaluated
mice
using
von
Kossa
staining,
calcium
content,
alkaline
phosphatase
activity
tests.
The
results
showed
significantly
improved
mice.
VSMCs
were
then
cultured
2.6
mM
Na2HPO4
50
μg/mL
ascorbic
acid
7
days
obtain
model,
investigated
by
assessing
changes
deposition,
subsequent
biomarkers.
These
alleviated
upregulating
expressions
TRPV1.
Moreover,
reduced
expression
Wnt3a
β-catenin,
whereas
DKK1
antagonised
inhibitory
VSMC
calcification.
first
offer
direct
evidence
inhibits
Wnt/β-catenin
signalling
pathway
TRPV1
receptor,
resulting
decreased
Runx2
BMP-2,
thereby
reducing
Our
may
provide
novel
strategies
progression
VC.
could
serve
as
theoretical
basis
clinically
treating
spicy
foods.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(8), С. 3414 - 3435
Опубликована: Июль 2, 2024
Additive
manufacturing,
commonly
known
as
3D
printing,
is
a
rapidly
advancing
technology
with
the
capability
to
create
intricate
and
precise
structures.
This
has
garnered
significant
attention
in
medical
field
due
its
ability
provide
personalized
diagnosis
treatment
services.
It
finds
applications
various
areas,
such
model
customized
implants,
even
organ
printing.
review
delves
into
current
uses
of
printing
urology,
including
preoperative
planning
for
surgeries,
education,
doctor–patient
communication,
implant
development.
also
showcases
examples
utilization
both
research
clinical
settings.
Moreover,
exploration
urethral
repair
urinary
reconstruction
offers
tailored
solutions
potential
replace
conventional
tissue
engineering
methods.
The
article
provides
an
overview
urology
discusses
future
prospects.
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 18, 2024
Abstract
Background
The
main
goal
of
this
study
was
to
examine
how
diabetes,
cardiovascular
calcification
characteristics
and
other
risk
factors
affect
mortality
in
end-stage
renal
disease
(ESRD)
patients
the
early
stages
hemodialysis.
Methods
A
total
285
ESRD
hemodialysis
were
enrolled
research,
including
101
with
diabetes.
Survival
time
monitored,
general
data,
biochemical
results,
cardiac
ultrasound
valvular
tissue,
thoracic
CT
coronary
artery
aorta
recorded.
Subgroup
analysis
logistic
regression
applied
investigate
association
between
diabetes
calcification.
Cox
survival
calcification,
all-cause
mortality.
Additionally,
nomogram
model
used
estimate
probability
for
these
individuals,
its
performance
evaluated
using
stratification,
receiver
operating
characteristic,
decision,
calibration
curves.
Results
Cardiovascular
found
81.2%
diabetic
(82/101)
33.7%
nondiabetic
(62/184).
Diabetic
had
lower
phosphorus,
calcium,
calcium-phosphorus
product,
plasma
PTH
levels
albumin
(p
<
0.001).
People
more
likely
have
than
people
without
(OR
5.66,
95%
CI
1.96–16.36;
p
overall
rate
14.7%
(42/285).
death
notably
greater
both
(29.27%,
24/82).
Diabetes
along
factors,
collectively
predict
patients.
demonstrated
excellent
discriminatory
power
(area
under
curve
(AUC)
=
0.975
at
5
years),
outstanding
low
high-risk
provided
greatest
net
benefit
across
a
wide
range
clinical
decision
thresholds.
Conclusions
In
during
period
haemodialysis,
significantly
increases
particularly
multisite
which
is
correlated
higher
rate.
scores
nomograms
developed
can
assist
clinicians
predicting
providing
individualised
treatment
plans
rates
