The prevalence of obesity in the adult population of the Russian Federation (literature review)

Obesity and metabolism, Год журнала: 2022, Номер 19(1), С. 96 - 105

Опубликована: Март 30, 2022

This review analyzes the prevalence of obesity among adult population in Russian Federation. The data various studies, including large international projects (WHO MONICA 1985–1995, HAPIEE 2003–2005), all-Russian screenings (RLMS - HSE 1993, Federal monitoring arterial hypertension 2003, ESSE-RF 2013 — present.), as well selected regional studies. In some regions, long-term dynamics has been studied. history studying epidemiology Russia more than thirty years. According to obtained, throughout country remains high and continues increase. Thus, men, increased from 10.8% 1993 27.9% 2017, women 26.4% 31.8%, respectively. all regions where it was possible assess trends, adults (maximum 48.5% Belgorod region). population, is common 47.0% Novosibirsk region) men 30.0% Ivanovo Voronezh regions). It necessary expand number which studies are carried out, strengthen measures combat overweight age groups country.

Язык: Английский

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Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2024, Номер 23(3), С. 3696 - 3696

Опубликована: Апрель 1, 2024

Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.

Язык: Русский

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Russian Society for the Prevention of Noncommunicable Diseases (ROPNIZ). Alimentary-dependent risk factors for chronic non-communicable diseases and eating habits: dietary correction within the framework of preventive counseling. Methodological Guidelines

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2021, Номер 20(5), С. 2952 - 2952

Опубликована: Сен. 16, 2021

The methodological guidelines are developed as a practical document for medical specialists working in the field of preventive medicine, order to expand and improve provision this type service adult population. include an informational informative part patients, presented format memos, contain main sections-healthy nutrition, correction eating habits, issues modifying diet alimentary-dependent risk factors chronic non-communicable diseases, such arterial hypertension, obesity, disorders lipid, carbohydrate purine metabolism, decrease bone mineral density. They intended prevention, doctors secondary personnel offices departments public health prevention centers, healthy lifestyle specialists, teachers educational institutions, who develop implement programs well therapeutic profile.

Язык: Английский

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A new aspect of metabolic disorders in obesity: carbonyl stress

Сибирский научный медицинский журнал, Год журнала: 2024, Номер 43(6), С. 24 - 33

Опубликована: Янв. 10, 2024

The literature review examines the problem of obesity in modern society. It has been shown that aggravates concomitant diseases, increases probability developing metabolic disorders and related pathologies, risk complications mortality. secretory function adipose tissue, its participation regulation biological processes is considered detail. concept carbonyl stress components revealed, role compounds body described, pathways leading to formation reaction products are shown, free radicals these noted. mechanisms pathogenesis associated with development discussed; greatest contribution car bonyl pathology made by two types processes: lipid peroxidation reactions resulting lipoperoxidation activated hyperglycemia (glycolysis, polyol hexоzamine pathways) glyoxal, methylglyoxal, active forms glucose. question advanced glycation end (AGEs) oxidation protein (AOРР) remains controversial. assumed AGEs AOРР levels depend on severity syndrome.

Язык: Английский

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Oxidative stress and exogenous constitutional obesity

Сибирский научный медицинский журнал, Год журнала: 2025, Номер 44(6), С. 69 - 82

Опубликована: Янв. 7, 2025

The literature review is devoted to the problem of exogenous-constitutional obesity and role oxidative stress (OS) in this form obesity. issues modern diagnostics pathogenesis are considered. results various studies study OS both laboratory animals humans presented. Excess body weight often accompanied by increased subclinical systemic inflammation. need correct antioxidant status a topical issue, an important part which individual approach selection agents dosages order reduce negative impact free radicals at cellular level. A significant lack single standard for determining parameters, requires standardized equipment, regard, choice specific method responsible step research specialist. In area, there still many questions that require more detailed study.

Язык: Английский

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Role of adipose tissue and obesity in the development of reproductive disorders in women

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 8, С. 44 - 51

Опубликована: Фев. 3, 2025

In recent decades, obesity has been a pressing medical and social problem for all countries, including the Russian Federation. Obesity is an independent risk factor development of many chronic diseases, reproductive metabolic disorders. The article presents data on prevalence among women. effect adipose tissue function shown - ovarian function, endometrium, as well activity hypothalamic-pituitary-ovarian system. relationship between polycystic ovary syndrome, infertility, menopausal syndrome discussed. mechanisms impact pathogenesis disorders in women are considered.

Язык: Английский

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The effect of a novel thienopyridine derivative on the liver structure of rats with diet-induced obesity

Kazan medical journal, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

BACKGROUND: The search for new pharmaceutical preparations that positively influence the morphofunctional state of liver while simultaneously exerting beneficial effects on carbohydrate and lipid metabolism is a relevant pressing task. AIM: Investigation effect novel thienopyridine derivative structure rats with diet-induced obesity. MATERIAL AND METHODS: Using in silico research via online services, code AZ-020 was selected as promising its potential condition, carbohydrate, metabolism. In vivo studies were conducted Wistar divided into five groups eight animals each: an intact group (standard housing conditions), control (animals receiving excessive amount palm oil at 30 g/kg 8 weeks), two comparison high-fat diet metformin 300 mg/kg 2 weeks (first group) or vildagliptin (second group)), experimental 1 weeks). structural condition morphometric parameters (number hepatocytes, count binucleated hepatocytes field view, hepatocyte size, area cytoplasm nuclei, nuclear-to-cytoplasmic ratio) studied using morphological methods. For statistical evaluation, fourfold table method used, determining criteria χ2 (Pearson), normalized Pearson, Pearson Yates’ correction, Fisher’s exact test. Morphometric data, considering their normal distribution, analyzed parametric statistics Student’s t-test. RESULTS: use histoarchitecture following disruption due to prolonged dietary load, positive trend changes key confirmed compared values group. application revealed statistically significant (1.7-fold 66%) increase number primary indicator regeneration. Pharmacological correction led normalization ratio, which decreased by 16% corresponding parameter rats. compound AZ-020, recorded 76.04±0.35 µm² (compared 75.54±0.31 control, p=0.0186), nuclei 11.13±0.24 13.9±0.3 p=0.000), average size 87.17±0.59 89.44±0.61 p=0.000). CONCLUSION: A from series cyanothioacetamide derivatives, laboratory demonstrates hepatoprotective models metabolic disorders injury.

Язык: Английский

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Iron deficiency states in metabolically burdened women in the pregravid period

Bulletin of Reproductive Health, Год журнала: 2025, Номер 4(1), С. 25 - 31

Опубликована: Фев. 22, 2025

Anemia is the most common health problem, especially among women. Iron deficiency affects approximately 4 billion people on planet (more than 60% of world’s population), and iron-deficiency anemia diagnosed in almost 2 people. Regardless age, causes decreased hemoglobin are iron folate deficiency. The systemic effects any etiology can lead to a significant deterioration quality life patients. each condition may differ at different periods woman’s life, but for women reproductive significance clinical consequences greatest, since adverse not only affect their body, also pregnancy outcomes newborns. one comorbidities obese patients, which allows us distinguish special phenotype («iron deficiency») obesity. There convincing evidence pathogenetic link between presence inflammation associated with In order prevent correct conditions treatment regimens using iron, folic acid, B12 or combinations have been developed introduced into practice.

Язык: Английский

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The impact of abdominal obesity correction in mature women on the structural and functional parameters of the myocardium and lipid metabolism parameters

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(4), С. 75 - 75

Опубликована: Апрель 28, 2025

Obesity is a serious medical problem. prevention social and biomedical task. Objective. To analyze the effect of program for correction grade I abdominal obesity in middle-aged premenopausal women on structural functional changes myocardium lipid composition peripheral blood. Materials methods. Anthropometric indicators, echocardiography examination, blood females diagnosed with control (n=25) main groups at age 42±1.5 years were analyzed. The data obtained during patient’s first visit after 6 months follow-up to track body weight due aerobic exercise. Results. integrated approach reducing normalizing pressure using exercise showed positive changes: decrease end-diastolic size left ventricle by 4.8%, ventricular mass index 5.4%, an increase ejection fraction 7.8%, normalization profile. Conclusions. Changes anthropometric parameters, disturbances profile, abnormal heart diastolic function are observed obese women. Rehabilitation wellness programs play crucial role organizing implementing treatment system. A significant improvement profile was who received comprehensive treating obesity.

Язык: Английский

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Adipocytokines: modern definition, classification and physiological role

Problems of Endocrinology, Год журнала: 2021, Номер 68(1), С. 73 - 80

Опубликована: Дек. 6, 2021

Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis inflammation. The studies show close connection between the imbalance formed result excessive deposit adipose in course development type 2 diabetes mellitus cardiovascular diseases. In present review, we summarize current data on effect liver, skeletal muscles, tissue, endothelial cells inflammatory processes, well attempt to define term «adipocytokines» classify according their influence metabolic processes pro-inflammatory status. Some (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α interleukin-6) are divided into two groups: reducing IR, increasing IR.

Язык: Английский

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