Inflammatory aging. Part 2. Are there diagnostic biomarkers available

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(1), С. 89 - 89

Опубликована: Янв. 1, 2025

Язык: Английский

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“Aging Clocks” Based on Cell-Free DNA

Biochemistry (Moscow), Год журнала: 2025, Номер 90(S1), С. S342 - S355

Опубликована: Фев. 1, 2025

Язык: Английский

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Melatonin at the health-resort stage of treatment and rehabilitation in national practice

Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина., Год журнала: 2024, Номер 1(1), С. 55 - 55

Опубликована: Янв. 1, 2024

Язык: Английский

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Polymorphism of genes involved in the regulation of blood pressure in elderly residents of the Arkhangelsk region

Ekologiya Cheloveka (Human Ecology), Год журнала: 2024, Номер 31(3), С. 233 - 246

Опубликована: Дек. 10, 2024

BACKGROUND: Living in the northern climate is associated with increased cardiovascular stress, which highlights necessity for study of candidate genes risk diseases both native population and newcomers. Polymorphic loci renin-angiotensin system, NO-synthase, endothelin-1 system have been identified as contributors to dysfunction age-related blood pressure shifts. It therefore crucial assess genetic polymorphism elderly population. AIM: To compare frequencies gene alleles genotypes involved regulation, including angiotensinogen AGT (rs699 rs4762), angiotensin 2 type 1 receptor AGTR1 (rs5186), converting enzyme ACE (rs4646994), endothelial NO synthase NOS3 EDN1 (rs5370) genes, non-native Arkhangelsk region. MATERIALS AND METHODS: A cross-sectional was conducted a random sample residents between ages 60 74 years (N=604, 36.4% males). The molecular analysis determine six that are regulation. Stata 18.0 software used deviations empirical genotype distributions from predicted Hardy–Weinberg equilibrium groups. RESULTS: Alleles were minor frequency analyzed variants consistent principle, exception T704C variant (rs699) participants. allele found be similar those reported worldwide European Russia. One A1166C frequencies, their 95% confidence intervals falling below global level This may suggest this selection adaptation regions. CONCLUSION: regulation populations However, among newcomers lower than observed globally.

Язык: Английский

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Inflammatory aging. Part 1. The principal biochemical mechanisms

Russian Journal of Preventive Medicine, Год журнала: 2024, Номер 27(12), С. 145 - 145

Опубликована: Янв. 1, 2024

Язык: Английский

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