C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Diseases, Год журнала: 2023, Номер 11(4), С. 132 - 132

Опубликована: Сен. 28, 2023

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces are sparse controversial. This critical state-of-the-art monography all the crucial data biochemical properties protein, along with further pathobiology, both for pentameric monomeric forms, including information ligands as well possible function autoantibodies against protein. Furthermore, utility biomarker various diseases is presented, cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, infections, autoimmune-supposed conditions neoplasms, other factors that have been linked elevated concentrations Moreover, molecular diagnostics CRP discussed, etiologies false test results highlighted. Additionally, this review evaluates systemic inflammation, highlights future goals. Finally, novel diagnostic algorithm to carefully assess level precise diagnosis medical condition illustrated.

Язык: Английский

Efficacy and safety of combining ginkgolide diterpene glucosamine injection with dual antibodies in elderly patients with acute ischemic stroke

Tropical Journal of Pharmaceutical Research, Год журнала: 2024, Номер 23(2), С. 423 - 428

Опубликована: Март 12, 2024

Purpose: To investigate the clinical effects and safety of ginkgo biloba diterpene lactone glucosamine injection, combined with dual antibiotic therapy for acute ischemic stroke in elderly individuals within a hyper thrombolytic time window. Methods: 100 patients at Changsha First Hospital, Changsha, China from March 2022 to 2023 were randomly equally assigned study control groups (50 each). Study group received aspirin clopidogrel, while injection along antibodies. Clinical efficacy, National Institutes Health Stroke Scale (NIHSS) score, Instrumental Activities Daily Living (IADL) cerebral hemodynamics, compared between two groups. Results: There was no significant difference effective rate (p > 0.05). However, following treatment, showed superior NIHSS IADL scores group, greater statistical significance as disease progressed. Doppler ultrasound revealed that had smaller Pulsatility index (PI) values larger mean artery blood flow velocity (Vm), systolic value (Vs) < In three adverse reactions reported (gastrointestinal discomfort, abnormal liver/kidney function, skin itching), whereas experienced five dizziness, itching). Conclusion: The combination Ginkgo antibodies super window enhances intracerebral levels, effectively promotes neurological recovery, improves daily living abilities, safety. Further research is needed elucidate exact pathways involved.

Язык: Английский