Neuroscience,
Год журнала:
2024,
Номер
557, С. 67 - 80
Опубликована: Авг. 9, 2024
Puberty
is
a
sensitive
developmental
period
during
which
stressors
can
cause
lasting
brain
and
behavioural
deficits.
While
the
acute
effects
of
pubertal
lipopolysaccharide
(LPS)
antimicrobial
(AMNS)
treatments
are
known,
their
enduring
impacts
on
neurodegeneration-related
mechanisms
behaviours
remain
unclear.
This
study
examined
these
in
male
female
mice.
At
five
weeks
old,
mice
received
200ul
either
broad-spectrum
antimicrobials
or
water
through
oral
gavage
twice
daily
for
seven
days.
six
age,
they
an
intraperitoneal
injection
saline
LPS.
Four
later,
adult
underwent
tests,
including
rotarod,
forepaw
stride
length,
reversed
grid
hang,
open
field,
buried
pellet
tests.
Two
days
after
final
test,
ileal
samples
were
collected.
Results
showed
that
treated
with
both
AMNS
LPS
exhibited
deficits
neuromuscular
strength,
while
males
alone
increased
anxiety-like
behaviours.
Males
had
decreased
sigma-1
receptor
(S1R)
expression
cornu
ammonis
1
(CA1)
dentate
gyrus
(DG),
females
S1R
expression.
Additionally,
lower
glial-derived
neurotrophic
factor
alpha-1
(GFRA1)
primary
motor
cortex
(M1)
than
females.
Mice
GFRA1
DG
secondary
(M2).
These
findings
suggest
may
lead
to
changes
biomarkers
related
neurodegeneration.
Diabetes,
Год журнала:
2023,
Номер
72(7), С. 872 - 883
Опубликована: Апрель 24, 2023
Diet
modulates
the
development
of
insulin
resistance
during
aging.
This
includes
tissue-specific
alterations
in
signaling
and
mitochondrial
function,
which
ultimately
affect
glucose
homeostasis.
Exercise
stimulates
clearance
lipid
oxidation
also
enhances
sensitivity
(IS).
It
is
not
well
known
how
exercise
interacts
with
age
diet
resistance.
To
investigate
this,
oral
tolerance
tests
tracers
were
conducted
mice
ranging
from
4
to
21
months
age,
fed
a
low-fat
(LFD)
or
high-fat
(HFD)
without
life-long
voluntary
access
running
wheel
(RW).
We
developed
computational
model
derive
fluxes,
commensurate
independent
values
steady-state
tracer
infusions.
Values
for
an
IS
index
derived
peripheral
tissues
(IS-P)
one
liver
(IS-L)
steeply
decreased
by
aging
HFD.
preceded
age-dependent
decline
capacity
oxidize
lipids.
In
young
animals
LFD,
RW
enhanced
IS-P
concomitantly
muscle
β-oxidation
capacity.
Surprisingly,
completely
prevented
IS-L
decrease;
however
this
only
occurred
LFD.
Therefore,
study
indicates
that
endurance
can
improve
organ-specific
if
paired
healthy
diet.
Article
Highlights
strategy
(IS),
whereas
lipid-rich
decrease
IS.
Using
tracer-based
test,
we
investigated
exercise,
interact
(voluntary
wheel)
mainly
improved
these
animals,
at
but
fully
hepatic
The
prevention
blunted
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 13, 2024
Decline
in
mitochondrial
function
is
linked
to
decreased
muscle
mass
and
strength
conditions
like
sarcopenia
type
2
diabetes.
Despite
therapeutic
opportunities,
there
limited
equivocal
data
regarding
molecular
cues
controlling
plasticity.
Here
we
uncovered
that
the
mRNA-stabilizing
protein
SLIRP,
complex
with
LRPPRC,
a
PGC-1α
target
regulates
structure,
respiration,
mtDNA-encoded-mRNA
pools
skeletal
muscle.
Exercise
training
effectively
counteracts
defects
caused
by
genetically-induced
LRPPRC/SLIRP
loss,
despite
sustained
low
pools,
increasing
mitoribosome
translation
capacity
quality
control.
In
humans,
exercise
robustly
increases
SLIRP
LRPPRC
across
modalities
sexes,
yet
less
prominently
individuals
loss
reduces
Drosophila
lifespan.
Our
points
mechanism
of
post-transcriptional
regulation
via
mRNA
stabilization,
offering
insights
into
how
enhances
control
alleviate
defects.
Muscle
lost
patients
diabetes,
which
associated
disfunction.
they
show
maintains
mitochondria
can
compensate
for
improving
Metabolites,
Год журнала:
2022,
Номер
12(10), С. 948 - 948
Опубликована: Окт. 5, 2022
Although
exercise
training
is
an
important
recommendation
for
the
management
of
type
1
diabetes
(T1D),
most
available
research
studies
predominantly
focus
on
male
subjects.
Given
importance
sex
as
a
biological
variable,
additional
are
required
to
improve
knowledge
gap
regarding
differences
in
T1D
research.
Therefore,
purpose
this
study
was
examine
role
mediating
changes
glucose
homeostasis
and
skeletal
muscle
metabolism
female
mice.
Female
mice
were
injected
with
streptozotocin
(STZ)
induce
T1D.
Two
weeks
after
STZ
injection,
control
(CON)
trained
treadmill
4
weeks.
Aerobic
failed
tolerance,
prevent
decrease
body
weight
adipose
tissue
mass,
or
attenuate
atrophy
However,
insulin
sensitivity
improved
training.
maintained
triglyceride
content
but
did
not
depletion
liver
glycogen
Gene
expression
analysis
suggested
that
resulted
decreased
transport,
ketone
oxidation,
increased
fatty
acid
muscle,
which
altered
by
These
data
demonstrate
aerobic
moderate
intensity
insufficient
counteract
negative
effects
mice,
does
lead
improvement
sensitivity.
Nutrients,
Год журнала:
2024,
Номер
16(16), С. 2731 - 2731
Опубликована: Авг. 16, 2024
The
ketogenic
diet
(KD)
is
a
high-fat,
low-carbohydrate
that
results
in
the
elevation
of
serum
ketone
bodies,
known
as
ketosis.
This
metabolic
consequence
has
been
suggested
method
for
treating
neurological
conditions,
improving
exercise
performance,
and
facilitating
weight
loss
overweight
individuals.
However,
since
most
research
primarily
uses
male
populations,
little
about
potential
sex
differences
during
consumption
KD.
In
addition,
effects
KD
on
aging
are
relatively
unexplored.
Therefore,
purpose
this
study
was
to
explore
sex-
age-specific
mice
fed
Male
female
C57BL/6N
at
either
12
wks
or
24
age
were
randomly
assigned
(90%
fat,
1%
carbohydrate)
chow
(13%
60%
group
6
wks.
induced
gain,
increased
adiposity,
hyperlipidemia,
caused
lipid
accumulation
heart
liver,
led
glycogen
depletion
heart,
muscle
with
varying
degrees
changes
depending
sex.
While
younger
older
prone
glucose
intolerance,
acutely
improved
rotarod
performance
females.
Overall,
highlights
adaptation
Abstract
Medium-intensity
activities
comprise
the
major
proportion
of
many
sorts
sports.
The
energy
consumption
athletes
has
been
a
research
emphasis
for
purpose
improving
both
training
efficiency
and
competition
performance.
However,
evidence
based
on
large-scale
gene
screen
rarely
performed.
This
is
bioinformatic
study
revealing
key
factors
contributed
to
metabolic
difference
between
subjects
with
different
endurance
activity
capacities.
A
dataset
comprised
high-
(HCR)
low-capacity
running
(LCR)
rats
was
used.
Differentially
expressed
genes
(DEGs)
were
identified
analysed.
Gene
Ontology
(GO)
Kyoto
Encyclopaedia
Genes
Genomes
(KEGG)
pathway
enrichment
obtained.
DEGs'
protein–protein
interaction
(PPI)
network
built,
enriched
terms
PPI
also
Our
findings
showed
that
GO
in
lipid
metabolism-related
terms.
KEGG
signalling
analysis
ether
metabolism.
Plb1,
Acad1,
Cd2bp2,
Pla2g7
as
hub
genes.
provides
theoretical
foundation
showing
metabolism
plays
an
important
role
performance
activities.
may
be
involved.
plan
diet
can
designed
above
results
expecting
better
competitive
Magnetic Resonance in Medicine,
Год журнала:
2023,
Номер
90(6), С. 2217 - 2232
Опубликована: Июль 26, 2023
Abstract
Purpose
Measuring
lipid
composition
provides
more
information
than
just
total
content.
Hence,
the
non‐invasive
measurement
of
unsaturated
protons
with
both
high
efficiency
and
precision
is
pressing
need.
This
study
was
to
optimize
echo
time
(TE)
for
best
resolving
J‐difference
editing
resonances.
Methods
The
TE
dependence
J‐difference‐edited
(JDE)
MRS
verified
in
density‐matrix
simulation,
soybean
oil
phantom,
in‐vivo
experiments
white
adipose
tissue
(WAT),
skeletal
muscles
using
single‐voxel
MEGA‐PRESS
sequence
at
3T.
peak
SNRs
Cramér‐Rao
lower
bounds
(CRLBs)
acquired
proposed
45
ms
previously
published
70
were
compared
(eight
pairs)
WAT,
extramyocelluar
lipids
(EMCLs),
intramyocellular
(IMCLs).
between
healthy
males
(
n
=
7)
females
7).
Results
optimal
suggested
as
ms.
Compared
ms,
mean
signal
gains
151%
168%
EMCL,
204%
IMCL
allylic
resonance,
52%
EMCL
diallylic
resonance.
CRLBs
significantly
reduced
resonance
With
significant
gender
differences
found
pools,
while
no
difference
pools.
Conclusion
JDE‐MRS
protocol
allows
improved
quantification
resonances
vivo
future
metabolism
investigations.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16441 - 16441
Опубликована: Ноя. 17, 2023
While
exercise
(EX)
during
pregnancy
is
beneficial
for
both
mother
and
child,
little
known
about
the
mechanisms
by
which
maternal
mediates
changes
in
utero.
Six-week-old
female
C57BL/6
mice
were
divided
into
two
groups:
with
(exercise,
EX;
N
=
7)
or
without
(sedentary,
SED;
8)
access
to
voluntary
running
wheels.
EX
was
provided
via
24
h
wheels
10
weeks
prior
conception
until
late
(18.5
days
post
coitum).
Sex-stratified
placentas
fetal
livers
collected.
Microarray
analysis
of
SED
revealed
that
affected
gene
transcript
expression
283
661
transcripts
male
placentas,
respectively
(±1.4-fold,
p
<
0.05).
Gene
Set
Enrichment
Ingenuity
Pathway
Analyses
showed
led
inhibition
signaling
pathways,
biological
functions,
down-regulation
related
lipid
steroid
metabolism,
while
activation
muscle
growth,
brain,
vascular
development,
growth
factors.
Overall,
our
results
suggest
effects
on
placenta
presumably
offspring
are
sexually
dimorphic.
Jurnal Kesehatan Masyarakat,
Год журнала:
2023,
Номер
11(1), С. 121 - 131
Опубликована: Янв. 31, 2023
Diseases
related
to
lipid
metabolism
continue
be
a
worldwide
concern.
Abnormal
levels
of
lipids,
especially
Low
Density
Lipoprotein
(LDL)
and
High
(HDL)
can
cause
cardiovascular
diseases
such
as
heart
attacks
strokes.
Until
now,
these
two
are
the
main
causes
death
globally
according
World
Health
Organization
(WHO).
In
addition
pharmacological
therapy
statins,
also
lowered
through
exercise.
Therefore,
this
review
article
aims
provide
information
about
types
exercise
that
reduce
blood
conditions
individual
groups
in
terms
age,
gender,
other
special
based
on
certain
disease
conditions.
It
was
found
most
widely
practiced
all
aerobic
This
is
suitable
for
pregnant
postmenopausal
women.
Concurrent
training
appropriate
Whereas
premenopausal
women,
water
more
effective
than
concurrent
training.
adult
men,
an
do
nordic
walk.
elderly,
done
stationary
cycling
with
one
leg
at
high
intensity.
Patients
Autistic
Spectrum
Disorder
(ASD)
perform
coordination
strength
exercises.
As
Multiple
Sclerosis
(MS)
patients,
exercises
walking/running
high-intensity
resistance
The
application
type
effectively
prevent
increase
levels.