Complications of rigid bronchoscopy

Respirology, Год журнала: 2020, Номер 26(1), С. 14 - 18

Опубликована: Июль 29, 2020

See related article

Язык: Английский

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Malignant Airway Stenosis Successfully Treated Using a Combination of Interventional Pulmonology, Chemotherapy, and Radiotherapy

Case Reports in Pulmonology, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Interventional pulmonology can be helpful in cases of malignant airway stenosis. We present a 73-year-old man diagnosed with lung cancer who presented symptomatic stenosis caused by large endobronchial tumor. Oncological treatment was started chemotherapy, radiotherapy, and multimodality bronchoscopic approach using balloon bronchoplasty, electrosurgery, argon plasma coagulation. Response evaluation showed relief symptoms, disappearance the tumor, complete resolution

Язык: Английский

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A Sheep in Wolf’s Clothing? Herpes-Simplex-Virus Endobronchial Pseudotumor

Respiratory Medicine Case Reports, Год журнала: 2024, Номер 52, С. 102111 - 102111

Опубликована: Янв. 1, 2024

Язык: Английский

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Bronchoscopic treatment of inoperable nonsmall cell lung cancer

European Respiratory Review, Год журнала: 2020, Номер 29(158), С. 200035 - 200035

Опубликована: Ноя. 5, 2020

Patients with unresectable lung cancer range from those early-stage or pre-invasive disease comorbidities that preclude surgery to advanced stage in whom is contraindicated. In such cases, a multidisciplinary approach treatment warranted, and may involve medical specialties including oncology, radiation oncology interventional pulmonology. this article we review bronchoscopic approaches surgically cancer, photodynamic therapy, brachytherapy, endoscopic ablation techniques airway stenting. Current past literature reviewed provide an overview of the topic, highlight potential emerging approaches.

Язык: Английский

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Alternative methods for local ablation—interventional pulmonology: a narrative review

Translational Lung Cancer Research, Год журнала: 2021, Номер 10(7), С. 3432 - 3445

Опубликована: Июль 1, 2021

Objective: To discuss and summarise the background recent advances in approach to bronchoscopic ablative therapies for lung cancer, focusing on focal parenchymal lesions.Background: This series focusses challenges highlighted by increasing recognition of prognostically more favourable oligometastatic disease rather than frequent, but poor, high tumour burden metastatic disease. While surgery, stereotactic body radiation therapy (SBRT), trans-thoracic percutaneous techniques such as microwave (MWA) radiofrequency ablation (RFA) are well recognised options selected cases pulmonary oligometastasis, approaches becoming realistic alternatives. An underlying tenet driving research implementation this domain is that obliged traverse pleura leading a rate pneumothorax, risks also goes up peri-vascular lesions. Historically low yield targeting isolated peripheral tumors have significantly improved incorporating multi-modality resolution imaging processing, including navigation planning real-time image guidances (ultrasound, electromagnetic navigation, cone-beam CT). Combining advanced guidance with technology adaptations delivery opens dose local may reduce transthoracic complications provide palliative curative limited stage primary diseases.Methods: We conduct narrative review literature summarizing history tumor approaches, technical details biologic rational their uses, current evidence each modality, investigations into future applications. Because relative paucity prospective studies, we been very inclusive our inclusion experiences from published clinical databases.Conclusions: Whilst surgical resection SBRT remain mainstay cancers, foreseeable future, developments further will see become viable sparing alternatives those deemed suitable. The bright.

Язык: Английский

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Therapeutic bronchoscopy followed by sequential radiochemotherapy in the management of life-threatening tracheal adenoid cystic carcinoma: a case report

Journal of Medical Case Reports, Год журнала: 2022, Номер 16(1)

Опубликована: Июнь 19, 2022

Abstract Background Adenoid cystic carcinoma of the lung is a distinctive salivary-gland-type malignant epithelial neoplasm that rarely presents as primary tumor respiratory tract. Complete surgical resection remains treatment choice for adenoid carcinoma. We present case large ACC tumors caused severe central airway obstruction and were effectively treated with therapeutic bronchoscopy followed by radiotherapy chemotherapy. Case presentation A 31-year-old Malay Indonesian female patient who was nonsmoker had no family history cancer admitted to emergency ward because worsening breathlessness accompanied stridor since 1 week prior. Chest computed tomography revealed segmental atelectasis left lung; mass on main bronchus, infiltrates in segments 1, 2, 3 consolidation inferior lobe, narrowing bronchus. Lobulated masses obstructing almost entire distal trachea up carina bronchus found bronchoscopy. Owing causing obstruction, medical team decided perform removal through rigid neodymium-doped yttrium-aluminum-garnet laser used first facilitate shrinkage. After treatment, mechanical using scope performed. The tracheal carinal lumens opened > 50% their diameter, lumen only slightly. stable, found. Adjuvant intensity-modulated chemotherapy performed after At end reevaluation thoracic scan remaining mass. Conclusions In cases nonresectable life-threatening sequential radiochemotherapy might achieve complete response outcome.

Язык: Английский

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Endoscopic Applications of Near-Infrared Photoimmunotherapy (NIR-PIT) in Cancers of the Digestive and Respiratory Tracts

Biomedicines, Год журнала: 2022, Номер 10(4), С. 846 - 846

Опубликована: Апрель 4, 2022

Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and promising therapy that specifically destroys target cells by irradiating antibody-photo-absorber conjugates (APCs) with NIR light. APCs bind to molecules on the cell surface, when exposed light, cause disruption of membrane due ligand release reaction dye aggregation. This leads rapid swelling, blebbing, rupture, which immunogenic death (ICD). ICD activates host antitumor immunity, assists in killing still viable cancer treated lesion but also capable producing responses untreated lesions. In September 2020, an APC laser system were conditionally approved for clinical use unresectable advanced head neck Japan, are now routine appropriate patients. However, most tumors have been relatively accessible oral cavity or neck. Endoscopes offer opportunity deliver light deeper within hollow organs body. recent years, application endoscopic as alternative surgery treatment has expanded, providing significant benefits inoperable this review, we will discuss potential applications NIR-PIT, especially thoracic gastrointestinal cancers.

Язык: Английский

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Malignant Central Airway Obstruction: What's New?

Seminars in Respiratory and Critical Care Medicine, Год журнала: 2022, Номер 43(04), С. 512 - 529

Опубликована: Июнь 2, 2022

Malignant central airway obstruction (MCAO) is a debilitating and life-limiting complication that occurs in an unfortunately large number of individuals with advanced intrathoracic cancer. Although the management MCAO multimodal interdisciplinary, task providing patients prompt palliation falls increasingly on shoulders interventional pulmonologists. While variety tools techniques are available for malignant obstructive lesions, advancements evolution this therapeutic venue have been somewhat sluggish limited when compared other branches pulmonary medicine (e.g., early diagnosis peripheral lung nodules). Indeed, one pragmatic, albeit uncharitable, reading article's title might suggest wry smile shug as to imply relatively little has changed recent years. That said, spectrum interventions continues expand, even if at less impressive clip. Herein, we present its endoscopic nonendoscopic management-that which old, new, still horizon.

Язык: Английский

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Recent research advances on simulation modeling of temperature distribution in microwave ablation of lung tumors

Computer Assisted Surgery, Год журнала: 2023, Номер 28(1)

Опубликована: Апрель 5, 2023

Lung tumor is the first malignant with highest mortality, but only no more than one-third of patients can be treated by surgical resection. Microwave ablation (MWA) has become a new adjuvant therapeutic mean for lung tumors because its low trauma, short treatment time, large volume and wide application range. However, parameters MWA, such as input power still depend on doctors’ experience, which leads to ineffectiveness MWA. Therefore, accurate modeling temperature distribution MWA significant technical problem solved. Recent research was devoted personalized characterization parameters, finite element analysis in effect evaluation. In this paper, review recently obtained results data will presented discussed.

Язык: Английский

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Comparison of operation time, efficacy and safety between through-the-scope stent and over-the-while stent in malignant central airway obstruction: a multi-center randomized control trial

Translational Lung Cancer Research, Год журнала: 2022, Номер 11(8), С. 1692 - 1701

Опубликована: Авг. 1, 2022

Self-expandable metallic (SEM) airway stents are an important approach to treating malignant central obstruction (CAO). Standard over-the-while (OTW) stent needs the guidance of a guide-wire. It should be implanted under flouroscopy or bronchoscope visualization. In this study, we evaluated operation time and safety between OTW novel through-the-scope (TTS) SEM stent.In multi-center, randomized, parallel-group superiority CAO patients were enrolled randomly assigned (2:1) TTS implantation group (TTS group) standard (OTW in six sites across China. The entire process all surgical procedures was recorded by video. Primary endpoint secondary success rate as well its efficacy safety.From May 15, 2017, December 30, 2018, 148 from sites. We analyzed 134 (including 91 43 according per-protocol set. There no significant differences ages, genders, underlying diseases, stenosis two groups. significantly shorter than that (104±68 vs. 252±111 seconds, P<0.001). Compared group, (97.80% 90.70%, P=0.093) first-time successful (78.02% 74.42%, P=0.668) higher but did not reach statistically significance. rates granulation (28.57% 41.86%, P=0.128) restenosis (15.38% 30.23%, P=0.064) slightly lower compared with without achieving statistical significance.The procedure similar complications, which might reduce risk flexibility implantation.Chinese Clinical Trial Registry ChiCTR-IOR-17011431.

Язык: Английский

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