COVID-19 and its long-term sequelae: what do we know in 2023?

Polskie Archiwum Medycyny Wewnętrznej, Год журнала: 2023, Номер unknown

Опубликована: Янв. 9, 2023

Post‑viral syndrome is a well‑known medical condition characterized by different levels of physical, cognitive, and emotional impairment that may persist with fluctuating severity after recovering from an acute viral infection. Unsurprisingly, COVID‑19 also be accompanied medium- long‑term clinical sequelae SARS‑CoV‑2 Although many definitions have been provided, "long‑COVID" can defined as occurring in patients history infection, developing 3 months the symptoms onset, persisting for at least 2 months, not explained alternative diagnoses. According to recent global analyses, cumulative prevalence long‑COVID seems range between 9% 63%, up 6‑fold higher than similar postviral infection conditions. Long‑COVID primarily encompasses presence 1 symptom, such fatigue, dyspnea, cognitive / brain fog, postexertional malaise, memory issues, musculoskeletal pain spasms, cough, sleep disturbances, tachycardia palpitations, altered smell taste perception, headache, chest pain, depression. The most important demographic predictors date are female sex, older age, cigarette smoking, pre‑existing conditions, lack vaccination, pre‑Omicron variants, number phase symptoms, load, severe critical illness, well invasive mechanical ventilation. Concerning care patients, greatest challenge fact this cannot considered single entity, thus it needs integrated multidisciplinary management, specifically tailored type symptoms.

Язык: Английский

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Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 15, 2022

Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery and development of de novo heart failure not investigated a large, nationally representative population. We examined outcomes 587,330 patients hospitalized United States (257,075 with 330,255 without), using data from National COVID Cohort Collaborative study. Patients were older (51 vs. 46 years), more often male (49% 42%), less White (61% 69%). Over median follow up 367 days, 10,979 incident events occurred. After adjustments, hospitalization was associated 45% higher hazard (hazard ratio = 1.45; 95% confidence interval: 1.39-1.51), pronounced associations among who younger (P-interaction 0.003), 0.005), or had established cardiovascular disease 0.005). In conclusion, is increased risk failure.

Язык: Английский

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Analysis of online search trends suggests that SARS-CoV-2 Omicron (B.1.1.529) variant causes different symptoms

Journal of Infection, Год журнала: 2022, Номер 84(5), С. e76 - e77

Опубликована: Фев. 17, 2022

Язык: Английский

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Arterial Thrombotic Events in Hospitalized COVID-19 Patients: A Short Review and Meta-Analysis

Seminars in Thrombosis and Hemostasis, Год журнала: 2022, Номер 49(01), С. 047 - 054

Опубликована: Июль 6, 2022

Abstract It is well established that the risk of venous thromboembolism high in coronavirus disease 19 (COVID-19). The frequency arterial thromboembolic events (ATEs) hospitalized patients with COVID-19 unclear, as magnitude these comparison other infections. We searched MEDLINE from February 2020 to 2022 for prospective or retrospective cohort studies and randomized clinical trials reported number acute myocardial infarction (AMI), ischemic stroke (AIS), limb ischemia (ALI), ATE defined by original authors COVID-19. pooled frequencies were calculated through meta-analysis using random effects model logit transformation presented relative 95% prediction intervals (95% PI). retrieved a total 4,547 studies, 36 which (28 cohorts, five cohorts three trials) finally included our analysis. resulting counted 100,949 patients, 2,641 (2.6%) whom experienced ATE. was 2.0% PI, 0.4–9.6%). AMI, AIS, ALI, 0.8% 0.1–8.1%), 0.9% 0.3–2.9%), 0.2% 0.0–4.2%), 0.5% 0.1–3.0%), respectively. In incidence on non-COVID viral pneumonia, we did not detect significant difference results conclusion, found non-negligible proportion Our are similar those influenza pneumonia.

Язык: Английский

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Antigenicity comparison of SARS‐CoV‐2 Omicron sublineages with other variants contained multiple mutations in RBD

MedComm, Год журнала: 2022, Номер 3(2)

Опубликована: Апрель 9, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, particularly those with multiple mutations in receptor-binding domain (RBD), pose a critical challenge to the efficacy of disease 2019 (COVID-19) vaccines and therapeutic neutralizing monoclonal antibodies (mAbs). Omicron sublineages BA.1, BA.2, BA.3, as well recent emergence C.1.2, B.1.630, B.1.640.1, B.1.640.2, have RBD may lead antibody evasion. It is urgent evaluate antigenic change above seven variants against mAbs sera from guinea pigs immunized concern (VOCs) (Alpha, Beta, Gamma, Delta, Omicron) interest (VOIs) (Lambda, Mu) immunogens. Only out 24 showed no reduction activity BA.3. However, among these mAbs, neutralization XGv337 XGv338 B.1.640.2 were decreased. Therefore, only five significant variants. Using VOCs VOIs immunogens, we found that antigenicity could be divided into three clusters, each cluster similar different Among them, D614G, B.1.630 formed cluster, C.1.2 BA.3 cluster.

Язык: Английский

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SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

Vaccines, Год журнала: 2022, Номер 10(8), С. 1193 - 1193

Опубликована: Июль 27, 2022

The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort more than 60,000 health workers.A multicentric retrospective study, involving 12 centers, was carried out within ORCHESTRA project, collecting data up 18 November 2021 on fully vaccinated workers. cumulative investigated with its association occupational social-demographic characteristics (age, sex, job title, previous infection, antibody titer levels, time from vaccination course completion).Among 64,172 workers 797 were observed (cumulative 1.2%). primary analysis using individual 8 centers showed that age infection significantly modified rates. In meta-analysis aggregated all standardized inversely related risk (p = 0.008 p 0.007, respectively).The inverse correlation supports evidence plays role prevention, especially Cellular immunity, clinical conditions, timing should be further investigated.

Язык: Английский

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Evolution of SARS-CoV-2 in Spain during the First Two Years of the Pandemic: Circulating Variants, Amino Acid Conservation, and Genetic Variability in Structural, Non-Structural, and Accessory Proteins

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6394 - 6394

Опубликована: Июнь 7, 2022

Monitoring SARS-CoV-2’s genetic diversity and emerging mutations in this ongoing pandemic is crucial to understanding its evolution ensuring the performance of COVID-19 diagnostic tests, vaccines, therapies. Spain has been one main epicenters COVID-19, reaching highest number cases deaths per 100,000 population Europe at beginning pandemic. This study aims investigate epidemiology SARS-CoV-2 18 Autonomous Communities across six epidemic waves established from February 2020 January 2022. We report on circulating variants each wave Spanish region analyze mutation frequency, amino acid (aa) conservation, most frequent aa changes structural/non-structural/accessory viral protein among sequences deposited GISAID database during period. The overall frequency was 1.24 × 10−5. conservation >99% three types protein, being non-structural conserved. Accessory proteins had more variable positions, while structural presented sequence. Six lineages spread successfully data provide an insight into circulation variability first two years

Язык: Английский

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In silico evaluation of the impact of Omicron variant of concern sublineage BA.4 and BA.5 on the sensitivity of RT‐qPCR assays for SARS‐CoV‐2 detection using whole genome sequencing

Journal of Medical Virology, Год журнала: 2022, Номер 95(1)

Опубликована: Окт. 20, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VoC) Omicron (B.1.1.529) has rapidly spread around the world, presenting a new threat to global public human health. Due large number mutations accumulated by SARS-CoV-2 Omicron, concerns have emerged over potentially reduced diagnostic accuracy reverse-transcription polymerase chain reaction (RT-qPCR), gold standard test for diagnosing disease 2019 (COVID-19). Thus, we aimed assess impact currently endemic sublineages BA.4 and BA.5 on integrity sensitivity RT-qPCR assays used (COVID-19) diagnosis via in silico analysis. We employed whole genome sequencing data evaluated potential false negatives or failure due mismatches between primers/probes VoC viral genome.In 12 tests (containing 30 primers probe sets) developed detection reported World Health Organization (WHO) available literature, was assessed specifically detecting sublineages, obtained after removing redundancy from publicly genomes National Center Biotechnology Information (NCBI) Global Initiative Sharing Avian Influenza Data (GISAID) databases. Mismatches amplicon regions sets were evaluated, clustering analysis corresponding sequences carried out.From 1164 representative sublineage analyzed, substitution first five nucleotides (C T) amplicon's 3'-end observed all samples resulting 0% HKUnivRdRp/Hel (mismatch reverse primer) CoremCharite N both forward primers). mismatch primer's 5'-end (3-nucleotide substitution, GGG AAC), ChinaCDC assay at 0.69%. The 10 nucleotide primer resulted 0.09% Thai assay. Of 1926 genomes, also had sensitivity. A 3.06% because AAC). Similarly, primer, assay's low 0.21% BA.5. Further, eight retained high (more than 97%) 9 more 99% sensitivity.We four (HKUnivRdRp/Hel, N, N) that could result negative results VoCs sublineages. Interestingly, Voc but 99.53% In addition, 66.67% 75% additional along with be modification development

Язык: Английский

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Deciphering the role of monocyte and monocyte distribution width (MDW) in COVID-19: an updated systematic review and meta-analysis

Clinical Chemistry and Laboratory Medicine (CCLM), Год журнала: 2023, Номер 61(6), С. 960 - 973

Опубликована: Янв. 10, 2023

The SARS-CoV-2 infection is characterized by both systemic and organ hyper-thromboinflammation, with a clinical course ranging from mild up-to critical dysfunction death. In patients coronavirus disease 2019 (COVID-19) the monocyte/macrophage population deeply involved as trigger target, assuming value of useful diagnostic/prognostic marker innate cellular immunity. Several studies correlated morphological immunophenotypic alterations circulating monocytes outcomes in COVID-19 patients, concluding that monocyte distribution width (MDW) may retain stratifying risk worsening. Through an electronic search Medline Scopus we performed updated literature review meta-analysis aimed to explore association between increased MDW levels illness severity deciphering role(s) function(s) harmful network underlining infection. We found significantly elevated values were frequently present who developed unfavorable outcomes, compounded significant anisocytosis outcomes. These findings suggest blood index its scatter plot could represent routine laboratory tools for early identification at higher monitoring progression viral infection, therapeutic efficacy throughout hospitalization. According this evidence, decisions benefit value, administration drugs limiting thrombo-inflammation due hyper-activation severe/critical disease.

Язык: Английский

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Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2

International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124009 - 124009

Опубликована: Март 16, 2024

Angiotensin-converting enzyme 2 (ACE2) is responsible for cell fusion with SARS-CoV viruses. ACE2 contained in different areas of the human body, including nasal cavity, which considered main entrance types airborne We took advantage roles and cavity SARS-CoV-2 replication transmission to develop a dry powder. Recombinant (rhACE2), after proper encapsulation achieved via spray freeze drying, shows binding efficiency spike proteins higher than 77 % at quantities lower 5 µg/ml. Once delivered nose, encapsulated rhACE2 led viability permeability RPMI 2650 cells least 90.20 ± 0.67 47.96 4.46 %, respectively, concentrations 1 mg/ml. These results were validated using powder containing prevent or treat infections derived from SARS-CoV-2.

Язык: Английский

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