Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches DOI Creative Commons
Aris Kaltsas, Athanasios Zikopoulos, V. Kojović

и другие.

Medicina, Год журнала: 2024, Номер 60(12), С. 1920 - 1920

Опубликована: Ноя. 22, 2024

Background and Objectives: Recurrent pregnancy loss (RPL) affects numerous couples worldwide has traditionally been attributed mainly to maternal factors. However, recent evidence highlights significant paternal influences on viability outcomes. This review aims comprehensively examine male contributions loss, focusing underlying mechanisms, novel biomarkers, integrated strategies for improved reproductive success. Materials Methods: A comprehensive narrative was conducted by searching databases including PubMed Embase the literature published from January 2004 October 2024. Studies in RPL—encompassing oxidative stress, genetic epigenetic health conditions, lifestyle factors, environmental exposures, advancements sperm proteomics—were included. Inclusion criteria were peer-reviewed articles English that directly addressed factors RPL; studies not meeting these excluded. Results: The identified such as advanced age, metabolic cardiovascular issues, chronic diseases, habits (e.g., smoking, alcohol consumption, poor diet), exposures significantly affect integrity through mechanisms like DNA fragmentation, alterations. Advanced age conditions are associated with increased risks of miscarriage adverse Novel proteomic biomarkers have identified, offering potential enhanced diagnostics personalized interventions. Integrated approaches involving multidisciplinary assessments, preventive strategies, counseling essential effectively addressing RPL. Conclusions: Integrating into clinical evaluations is crucial recurrent loss. Recognizing modifying risk changes, medical interventions, management can improve findings underscore need incorporating assessments standard care highlight importance future research standardizing diagnostic protocols, expanding contributions, integrating practice facilitate treatment strategies.

Язык: Английский

Circulating levels of cytokines (IL-6, IL-10 and TGF- β) and CD4+CD25+FOXP3+Treg cell population in recurrent pregnancy loss DOI
Sufaya Jameel, Rashmi Bhuwalka,

Mahmooda Begum

и другие.

Reproductive Biology, Год журнала: 2024, Номер 24(1), С. 100842 - 100842

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

6
Impact of Vitamin D deficiency on immunological and metabolic responses in women with recurrent pregnancy loss: focus on VDBP/HLA-G1/CTLA-4/ENTPD1/adenosine-fetal-maternal conflict crosstalk DOI Creative Commons

Aisha Nawaf Al balawi,

Noaf Abdullah N. Alblwi,

Riham Soliman

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 29, 2024

Recurrent pregnancy loss (RPL), also known as recurrent implantation failure (RIF), is a distressing condition affecting women characterized by two or more consecutive miscarriages the inability to carry beyond 20 weeks. Immunological factors and genetic variations, particularly in Vit D Binding Protein (VDBP), have gained attention potential contributors RPL. This study aimed provide insight into immunological, genetic, metabolic networks underlying RPL, placing particular emphasis on interactions between VDBP, HLA-G1, CTLA-4, ENTPD1, adenosine-fetal-maternal conflict crosstalk. A retrospective included 198 with three spontaneous abortions. Exclusion criteria comprised uterine abnormalities, endocrine disorders, parental chromosomal infectious factors, autoimmune diseases, connective tissue diseases. interplay was investigated 162 female participants, divided groups based their levels: normal D-RPL low D-RPL. Various laboratory techniques were employed, including LC/MS/MS for measurement, ELISA protein detection, flow cytometry immune function analysis, molecular docking protein–ligand interaction assessment. General characteristics significant regarding glucose levels. Low levels associated decreased NK cell activity downregulation of HLA-G1 HLA-G5 proteins, while CTLA-4 revealed upregulation. VDBP significantly downregulated group. Our findings highlight intricate relationship status adenosine metabolism SGLT1, NT5E, key components metabolism, suggests that deficiency may disrupt regulation levels, leading an impaired reproductive outcome. HNF1β, negative regulator upregulated, HNF1α, positive regulator, after Molecular analysis crucial residues involved HNF1β. Collectively, these underscore importance modulating pathways relevant maintenance, highlighting need further research elucidate mechanisms therapeutic interventions improving outcomes individuals

Язык: Английский

Процитировано

4
Intradermal lymphocyte therapy: A promising treatment for recurrent pregnancy loss in patients without anti-TPO antibodies DOI
R Ebrahimi, Kimia Motlagh Asghari, Sina Janbaz Alamdary

и другие.

Human Immunology, Год журнала: 2025, Номер 86(2), С. 111229 - 111229

Опубликована: Янв. 10, 2025

Язык: Английский

Процитировано

0
Exploring the Role of Lower Genital Tract Microbiota and Cervical–Endometrial Immune Metabolome in Unknown Genesis of Recurrent Pregnancy Loss DOI Open Access
S.A. Mikhalev, М. А. Курцер, V.E. Radzinsky

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1326 - 1326

Опубликована: Фев. 4, 2025

Recurrent pregnancy loss (RPL) of unknown genesis is a complex condition with multifactorial origins, including genetic, hormonal, and immunological factors. However, the specific mechanisms underlying endocervical cell proliferation disorders in women RPL remain inadequately understood, particularly concerning role microbiota viral infections. The aim this study was to investigate by examining microbiota, human papillomavirus (HPV) typing, expression levels key molecular biological markers, p16/Ki-67, BCL-2, miR-145, miR-34a. A prospective observational comparative executed on healthy pregnant controls full ethical approval. Samples were collected for HPV typing immunocytochemical analysis evaluate p16, Ki-67, anti-oncogenic microRNAs (miR-145 miR-34a). mRNA progesterone receptor (PGR-A) also assessed, alongside local immune status proinflammatory T-lymphocytes (Th17/Th1) regulatory CD4+ Tregs. Overexpression BCL-2 observed 52.5% who had an ASC-US/LSIL cytogram, average double p16/Ki-67 being three times higher than group. significant decrease PGR-A endocervix noted, accompanied dysregulated characterized increased prevalence Th17/Th1 cells reduction Additionally, miR-145 miR-34a endometrium significantly differed from physiological group, context high-risk infection. findings describe that are associated overexpression impaired regulation, altered microRNA profiles. These alterations may contribute pathophysiology RPL, highlighting need further research into targeted interventions could improve reproductive outcomes affected individuals.

Язык: Английский

Процитировано

0
Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets DOI
Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hjazi

и другие.

Human Immunology, Год журнала: 2025, Номер 86(3), С. 111264 - 111264

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

0
PD-L1 Gene Variants as Predictors of Recurrent Pregnancy Loss: A Case-control Study among Kazakh women in Central and West Kazakhstan DOI
Wassim Y. Almawi, Gulzhanat Aimagambetova,

Abay Tursunov

и другие.

Journal of Reproductive Immunology, Год журнала: 2025, Номер unknown, С. 104524 - 104524

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Immunologic Factors and Genomic Considerations in Recurrent Pregnancy Loss: A Review DOI Open Access
Fateme Montazeri, Masoud Tajamolian,

Elham Sadat Hosseini

и другие.

International Journal of Medical Laboratory, Год журнала: 2024, Номер unknown

Опубликована: Март 2, 2024

Recurrent pregnancy loss (RPL), which is also known as repeated miscarriage, affects around 2-3% of women who are trying to conceive. While some factors contributing RPL have been identified, the cause almost half all cases remains unknown. Immunological proposed one potential causes such miscarriages. However, it hard track common leading since individual genomic identity aborted fetuses different in a family like other siblings. The immunological involved pathogenesis miscarriage generally result from either function maternal immune system attributable her background or fetal origination established by both and paternal backgrounds that constitute genome.

Язык: Английский

Процитировано

2
A critical review of the recent concept of regulatory performance of DNA Methylations, and DNA methyltransferase enzymes alongside the induction of immune microenvironment elements in recurrent pregnancy loss DOI Creative Commons

Kosar Babaei,

Mohsen Azimi‐Nezhad, Ebrahim Mirzajani

и другие.

Toxicology Reports, Год журнала: 2024, Номер 12, С. 546 - 563

Опубликована: Май 9, 2024

Recurrent pregnancy Loss (RPL)is a frequent and upsetting condition. Besides the prevalent cause of RPL including chromosomal defects in embryo,the effect translational elements like alterations epigenetics are great importance. The emergence has offered fresh outlook on causes treatment by focusing examination DNA methylation. may arise as result aberrant methylation imprinted genes, placenta-specific immune-related sperm DNA, which have direct or indirect impact embryo implantation, growth, development. Moreover, distinct immunological tolerogenic milieu established at interface between mother fetus plays crucial role sustaining pregnancy. Given this, there been deal interest regulation cellular components maternal-fetal milieu. research methylation's incidence control mother-fetal is summed up this review.

Язык: Английский

Процитировано

2
TLR signaling pathway and the effects of main immune cells and epigenetics factors on the diagnosis and treatment of infertility and sterility DOI Creative Commons

Kosar Babaei,

Mohsen Azimi Nezhad,

Seyedeh Nafise Sedigh Ziabari

и другие.

Heliyon, Год журнала: 2024, Номер 10(15), С. e35345 - e35345

Опубликована: Июль 27, 2024

Recurrent pregnancy loss (RPL), often known as spontaneous miscarriages occurring two or more times in a row, is reproductive disease that affects certain couples. The cause of RPL unknown many cases, leading to difficulties therapy and increased psychological suffering Toll-like receptors (TLR) have been identified crucial regulators inflammation various human tissues. occurrence during parturition indicates receptor activity tissues related may play role the onset continuation normal function, well complications like infection-related preterm. TLRs their signaling molecules serve effective therapeutic targets for inhibiting premature activity. At maternal-fetal interface, are found both immune non-immune cells, such trophoblasts decidual cells. TLR expression patterns influenced by phases pregnancy. In this way, translational combinations epigenetics, indicated impact on TLRs.Importantly, abnormal DNA methylation histone alterations an impressive performance decreasing fertility influencing gene required molecular cellular activities which vital embryonic process. TLRs, central duty innate system can regulate epigenetic elements different pathways. potential roles epigenetics factors ability identify react infections, place will all be covered narrative review essay.

Язык: Английский

Процитировано

2
Association of inherited thrombophilia mutations and their combinations among palestinian women with unexplained recurrent miscarriage DOI Creative Commons
A. Al Najjar,

Imam Hassouna,

Mahmoud A. Srour

и другие.

Thrombosis Journal, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 13, 2024

Abstract Background Inherited thrombophilia (IT) has a complex pathophysiology and is associated with recurrent miscarriage (RM) by causing placental insufficiency inhibiting fetal development. However, screening in unexplained RM cases still questionable. This study aimed to investigate the association between common eight IT mutations their combinations among Palestinian women RM. Methods an unmatched case-control 200 (100 cases, 100 controls). Eight namely Factor V Leiden (FVL), prothrombin gene (FII) G202120A, Methylenetetrahydrofolate Reductase (MTHFR) (C677T A1298C), B-fibrinogen − 455G > A, FV HR2 A4070G, Plasminogen activator inhibitor 1 (PAI1) 5G/4G XIIIA (FXIIIA) V34L; were analyzed. The first five analyzed Restriction Fragment Length Polymorphism PCR other three using Amplification Refractory Mutation System PCR. Results prevalence of control group was order PAI1 (69%), MTHFR C677T (53%) A1298C (47%), BFG A (35%), FVL (each 18%), FXIIIA V34L (16%) FII G20210A (3%). Patients had higher percentage (heterozygotes mutant homozygote) compared controls ( p = 0.016). Frequencies alleles < 0.001) 0.009) patients controls. No significant differences observed for all or alleles. Most (75%) have 2–4 out 8 studied, while 1% 2% zero None most often studied (FVL, G20210A, C1677T, A1298C) showed difference Conclusions There V34L. combination both studied. report that evaluates inherited alleles’ cases.

Язык: Английский

Процитировано

1