Plasmonics, Год журнала: 2023, Номер 19(4), С. 1903 - 1916
Опубликована: Ноя. 23, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 786 - 786
Опубликована: Янв. 8, 2024
Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve therapy. Such play crucial role enhancing bioavailability substances, affecting therapy efficiency and precision. The targeted delivery drugs sites action minimization toxicity body is becoming possible through use these advanced carriers. Recent research has focused structures based biopolymers, including lipids, polysaccharides, proteins. This review paper description lipid-containing nanocomposite (including liposomes, lipid emulsions, nanoparticles, solid nanostructured carriers), polysaccharide-containing alginate cellulose), protein-containing (e.g., gelatin albumin). It was demonstrated many investigations that such show ability load therapeutic substances efficiently precisely control release. They also desirable biocompatibility, which promising sign for their potential application development indicates novel approach improving processes, contribute significant advances pharmacology, efficacy while minimizing side effects.
Язык: Английский
Процитировано
20
Nutrients, Год журнала: 2023, Номер 15(14), С. 3136 - 3136
Опубликована: Июль 13, 2023
Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), resveratrol have been highlighted antiproliferative agents for cancer. Due their low solubility limited bioavailability, some alternative nanotechnologies applied encapsulate these compounds, aiming improve efficacy against In this comprehensive review, we evaluate the main nanotechnology approaches therapeutic potential of polyphenols cancer using in vitro studies vivo preclinical models, highlighting recent advancements field. It was found that polymeric nanomaterials, lipid-based inorganic carbon-based nanomaterials most used classes nanocarriers encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity pro-apoptotic effects, particularly breast, lung, prostate, cervical, colorectal cells, surpassing performance free compounds. Preclinical trials xenograft animal models revealed decreased tumor growth after treatment with polyphenol-loaded systems. Moreover, interaction polyphenol co-delivery polyphenol–drug is a promising approach increase anticancer decrease chemotherapy side effects. innovative hold significant implications advancement clinical research.
Язык: Английский
Процитировано
39
Plasmonics, Год журнала: 2023, Номер 19(3), С. 1187 - 1200
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
30
European Polymer Journal, Год журнала: 2024, Номер 214, С. 113187 - 113187
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
15
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116951 - 116951
Опубликована: Июнь 19, 2024
The emerging strategy of biomimetic nanoparticles (NPs) via cellular membrane camouflage holds great promise in cancer therapy. This scholarly review explores the utilization membranes derived from diverse entities; blood cells, immune stem and bacterial cells as examples NP coatings. camouflaging endows NPs with nuanced tumor-targeting abilities such self-recognition, homotypic targeting, long-lasting circulation, thus also improving tumor therapy efficacy overall. comprehensive examination encompasses a variety cell camouflaged (CMCNPs), elucidating their underlying targeted mechanisms delineating strategies for anti-cancer applications. Furthermore, systematically presents synthesis source materials methodologies employed order to construct characterize these CMCNPs, specific emphasis on use treatment.
Язык: Английский
Процитировано
13
Heliyon, Год журнала: 2024, Номер 10(2), С. e24207 - e24207
Опубликована: Янв. 1, 2024
High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have by 2045 global prevalence disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these come with undesirable side effects, so it's encouraging that research into plant extracts bioactive substances characteristics is on Natural remedies preferable conventional anti-diabetic since they safer for body, more affordable fewer potential adverse effects. Biological macromolecules such liposomes, niosomes, polymeric nanoparticles, solid lipid nanoemulsions metallic nanoparticles explored in this review. Current drug restrictions been addressed, effectiveness plant-based therapies has enhanced merits methods. Plant extracts' loading capacity carriers' stability primary obstacles developing nanocarriers. Hydrophilic, hydrophobic, amphiphilic covered, brief overview amphipathic features phospholipids, nanocarriers provided. Metallic nanoparticles' benefits attendant risks highlighted emphasize their efficiency treating hyperglycemia. Researchers interested loaded therapeutics may find current helpful
Язык: Английский
Процитировано
10
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105838 - 105838
Опубликована: Июнь 3, 2024
Язык: Английский
Процитировано
8
Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер 6
Опубликована: Янв. 3, 2025
Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer. Surgery, chemotherapy, immunotherapy, and radiation have mostly failed to These drugs may damage quickly dividing healthy tissues, structural anomalies, bodily toxicity, long-term side effects, tumor cell resistance, psychiatric disturbances. Researchers developing nanoscale medicines using medications like Malva sylvestris Curcumin lower concentrations improve target specificity. Nanoparticles' small size unique properties make them beneficial. They encapsulate medicinal ingredients, improving solubility, medication release, cellular absorption, delivery. Nanoparticles better identify bind cancer cells when functionalized with ligands. Natural chemicals nanotechnology availability, distribution, targeting cells, making treatments more effective safe. Nanomedicine, which employs nanoparticles malignant has grown rapidly because nanodrugs fewer effects than current commercial drugs. Nanotechnology-based pharmaceutical delivery methods therapy covered in this review article. The paper discusses nanoparticle pros cons chemicals' cancer-fighting appeal.
Язык: Английский
Процитировано
1
Food Science and Biotechnology, Год журнала: 2025, Номер 34(9), С. 1819 - 1834
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
1
Pharmacology & Therapeutics, Год журнала: 2024, Номер 256, С. 108611 - 108611
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
6