Open Life Sciences,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
Breast
cancer
(BC)
has
a
prevalence
rate
of
21.8%
among
Saudi
women
and
ranks
as
the
third
leading
cause
death
in
Western
nations.
Nanotechnology
offers
innovative
methods
for
targeted
BC
therapy,
this
study
explores
use
single-walled
carbon
nanotubes
(SWCNTs)
delivering
senna
leaf
extract.
The
evaluated
effects
increasing
dosages
extract
conjugated
to
SWCNTs
on
MCF-7
cells.
Cell
viability
was
assessed
using
MTT
assay,
while
Giemsa
staining
revealed
morphological
changes.
Additionally,
comet
assay
agarose
gel
electrophoresis
were
employed
evaluate
pro-apoptotic
potential.
potential
mitochondrial
membrane
production
reactive
oxygen
species
(ROS)
investigated
JC-1
dye.
results
indicated
that
treated
cells
exhibited
apoptotic
characteristics,
including
elevated
ROS
levels
decreased
In
summary,
application
nanotechnology
deliver
shows
promise
herbal
treatment
BC,
suggesting
breakthrough
combating
widespread
deadly
disease.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 25, 2024
Abstract
An
essential
research
area
for
scientists
is
the
development
of
high-performing,
inexpensive,
non-toxic
antibacterial
materials
that
prevent
transfer
bacteria.
In
this
study,
pure
Bi
2
WO
6
and
/MWCNTs
nanocomposite
were
prepared
by
hydrothermal
method.
A
series
characterization
results
using
XRD
FTIR,
Raman,
FESEM,
TEM,
EDS
analyses,
reveal
formation
orthorhombic
nanoflakes
addition
NaOH
pH
adjustment
to
7.
Compared
,
exhibited
CNTs
are
efficiently
embedded
into
structure
which
in
charge
between
metal
ion
electrons
conduction
or
valence
band
MWCNTs
result
shifting
longer
wavelength
as
shown
UV–visible
PL.
The
confirmed
stuck
surface
microflowers,
some
them
inside
without
affecting
demonstrated
TEM.
addition,
Pure
tested
against
P.
mirabilis
S.
mutans.,
confirming
effect
had
better
activity
opposition
both
bacterial
strains
than
.
Besides,
cytotoxicity
lung
MTT
test
on
Hep-G2
liver
cancer
cells,
flow-cytometry.
Results
indicated
have
significant
anti-cancer
efficacy
cells
vitro.
findings
triggered
cell
death
via
increasing
ROS.
Based
these
findings,
it
appears
potential
be
developed
nanotherapeutics
treatment
infections,
cancer.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101519 - 101519
Опубликована: Янв. 1, 2024
One
of
the
most
important
goals
current
research
in
medical
field
is
to
identify
treatments
for
antimicrobial
resistance
(AMR)
and
cancer.
The
latest
developments
nanotechnology
have
provided
opportunities
develop
novel
nanomaterials
that
can
overcome
limitations
treatments.
In
this
regard,
carbon
nanotubes
(CNTs)
are
considered
potential
nano-tools
with
attractive
implications.
analysis
MTZ/SWCNT/AgNPs
study
was
done
using
different
techniques,
including
SEM,
TEM,
FTIR,
XRD,
EDX.
Antibacterial
activity
assessed
MTN/SWCNT/AgNPs
against
Escherichia
coli,
Pseudomonas
aeruginosa,
Enterococcus
faecalis,
Staphylococcus
aureus.
effects
MTZ/SWCNTs/AgNPs
on
mitochondrial
apoptotic
activities
human
gastric
cancer
(AGS)
were
evaluated.
Overall,
new
CNTs
produced
efficiently.
efficient
antibacterial
anticancer
agents
biological
applications.
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(5)
Опубликована: Март 1, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
caused
by
the
progressive
deposition
of
extracellular
amyloid
beta
(Aβ)
and
intracellular
neurofibrillary
tangles
(NFTs).
Of
note,
metabolic
disorders
such
as
insulin
resistance
(IR)
type
2
diabetes
(T2D)
are
associated
with
development
brain
IR
neurodegeneration.
In
addition,
AD
neuropathology
linked
cognitive
impairment
accelerate
peripheral
progression
T2D.
Therefore,
there
bidirectional
relationship
between
T2D
AD.
It
has
been
demonstrated
that
induce
dysregulation
peroxisome
proliferator-activated
receptor
alpha
(PPAR-α)
leading
to
central
disturbances.
Hence,
dysregulated
PPAR-α
could
be
shared
mechanism
in
both
T2D,
restoration
signalling
agonist
fenofibrate
(FN)
may
alleviate
this
review
aims
shed
light
on
potential
involvement
AD,
how
FN
effective
management
seems
dual
neuroprotective
antidiabetic
effects
can
mitigate
T2D-related
complications
modulating
various
cellular
processes
inflammatory
pathways.
conclusion,
possible
candidate
different
pathways
involved
pathogenesis
these
conditions.
