Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 288 - 288
Опубликована: Фев. 22, 2025
Cyclodextrins
(CDs)
have
revolutionized
the
pharmaceutical
industry
with
their
ability
to
enhance
stability,
solubility,
and
bioavailability
of
a
wide
range
active
substances.
These
cyclic
oligosaccharides,
unique
hydrophilic
exterior
hydrophobic
cavity,
form
inclusion
complexes
poorly
soluble
drugs,
improving
pharmacokinetic
profiles
therapeutic
efficacy.
This
review
explores
multifaceted
roles
cyclodextrins
in
formulations,
ranging
from
oral,
ophthalmic,
parenteral,
topical
applications
emerging
use
targeted
therapies,
gene
delivery,
treatment
neurodegenerative,
cardiovascular,
infectious
diseases.
not
only
improve
drug
solubility
controlled
release
but
also
reduce
toxicity
side
effects,
leading
safer
more
effective
treatments.
Recent
advancements,
such
as
cyclodextrin-based
nanoparticles,
offer
promising
pathways
for
cancer
therapy,
chronic
disease
management,
personalized
medicine.
As
research
continues,
remain
at
forefront
innovation
delivery
systems,
ensuring
better
patient
outcomes
expanding
possibilities
modern
therapeutics.
Язык: Английский
Chemical and physical characterization, stability and antioxidant activity of avicularin/(2-hydroxypropyl)-β-cyclodextrin inclusion complex
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106201 - 106201
Опубликована: Фев. 1, 2025
Язык: Английский
Research Trends in the Development of Block Copolymer-Based Biosensing Platforms
Biosensors,
Год журнала:
2024,
Номер
14(11), С. 542 - 542
Опубликована: Ноя. 8, 2024
Biosensing
technology,
which
aims
to
measure
and
control
the
signals
of
biological
substances,
has
recently
been
developed
rapidly
due
increasing
concerns
about
health
environment.
Top–down
technologies
have
used
mainly
with
a
focus
on
reducing
size
biomaterials
nano-level.
However,
bottom–up
such
as
self-assembly
can
provide
more
opportunities
molecular-level
arrangements
directionality
shape
biomaterials.
In
particular,
block
copolymers
(BCPs)
their
significantly
explored
an
effective
means
achieve
recent
advances
in
fine
imaging
technology.
BCPs
widely
various
biosensing
research
fields
because
they
artificially
highly
complex
nano-scale
structures
directionally
controlled
manner,
future
application
based
interactions
biomolecules
according
development
synthesis
new
BCP
is
greatly
anticipated.
Here,
we
comprehensively
discuss
basic
principles
current
status
applications
limitations
prospects.
Rather
than
discussing
specific
field
depth,
this
study
covers
overall
content
platform,
through
this,
hope
increase
researchers’
understanding
adjacent
inspiration,
thereby
bringing
great
relevant
fields.
Язык: Английский
Cyclodextrin-transition metal complexes emerge as promising tools for modulating peptide function
Journal of Molecular Liquids,
Год журнала:
2024,
Номер
unknown, С. 126621 - 126621
Опубликована: Дек. 1, 2024
Язык: Английский
PEO-b-PCL/Tween 80/cyclodextrin systems: from bioinspired fabrication to possible nasal administration of ropinirole hydrochloride
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(27), С. 6587 - 6604
Опубликована: Янв. 1, 2024
Hybrid
PEO-
b
-PCL/Tween
80/cyclodextrin
systems:
physicochemical
and
morphological
characterization,
in
vitro
release
studies.
Язык: Английский
Surface spin engineering of InBiSe3 enabled self-powered polarization-sensitive photodetector
Applied Surface Science,
Год журнала:
2024,
Номер
unknown, С. 162024 - 162024
Опубликована: Дек. 1, 2024
Язык: Английский
Enhancing non-viral DNA delivery systems: Recent advances in improving efficiency and target specificity
Journal of Controlled Release,
Год журнала:
2024,
Номер
378, С. 170 - 194
Опубликована: Дек. 12, 2024
DNA-based
therapies
are
often
limited
by
challenges
such
as
stability,
long-term
integration,
low
transfection
efficiency,
and
insufficient
targeted
DNA
delivery.
This
review
focuses
on
recent
progress
in
the
design
of
non-viral
delivery
systems
for
enhancing
modulation
therapeutic
efficiency.
Cellular
uptake
intracellular
trafficking
mechanisms
play
a
crucial
role
optimizing
gene
There
two
main
strategies
employed
to
improve
efficiency
vectors:
(i)
explore
different
administration
routes
(e.g.,
mucosal,
intravenous,
intramuscular,
subcutaneous,
intradermal,
intratumoural,
intraocular)
that
best
facilitates
optimal
into
cells
organs
(ii)
modify
vectors
with
cell-specific
ligands
natural
ligands,
antibodies,
peptides,
carbohydrates,
or
aptamers)
enable
specific
higher
specificity
improved
biodistribution.
We
describe
how
employing
these
is
advancing
field
increasing
clinical
translation
ultimate
application
therapies.
Язык: Английский