The association between C-reactive protein-albumin-lymphocyte index and depression in adults with type 2 diabetes mellitus: A cross-sectional study from NHANES
Psychoneuroendocrinology,
Год журнала:
2025,
Номер
unknown, С. 107442 - 107442
Опубликована: Март 1, 2025
Язык: Английский
Redefining Roles: A Paradigm Shift in Tryptophan–Kynurenine Metabolism for Innovative Clinical Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12767 - 12767
Опубликована: Ноя. 27, 2024
The
tryptophan-kynurenine
(KYN)
pathway
has
long
been
recognized
for
its
essential
role
in
generating
metabolites
that
influence
various
physiological
processes.
Traditionally,
these
have
categorized
into
distinct,
often
opposing
groups,
such
as
pro-oxidant
versus
antioxidant,
excitotoxic/neurotoxic
neuroprotective.
This
dichotomous
framework
shaped
much
of
the
research
on
conditions
like
neurodegenerative
and
neuropsychiatric
disorders,
well
cancer,
where
metabolic
imbalances
are
a
key
feature.
effects
significantly
influenced
by
factors,
including
concentration
particular
cellular
milieu
which
they
generated.
A
molecule
acts
neuroprotective
at
low
concentrations
may
exhibit
neurotoxic
elevated
levels.
oxidative
equilibrium
surrounding
environment
can
alter
function
KYN
from
an
antioxidant
to
pro-oxidant.
narrative
review
offers
comprehensive
examination
analysis
contemporary
understanding
metabolites,
emphasizing
their
multifaceted
biological
functions
relevance
numerous
pathological
underscores
pressing
necessity
paradigm
shift
comprehension
metabolism.
Understanding
context-dependent
roles
is
vital
novel
therapies
Alzheimer's
disease,
multiple
sclerosis,
cancer.
Comprehensive
modulation,
balancing
inflammatory
signals
enzyme
regulation,
promising
avenues
targeted,
effective
treatments.
Язык: Английский
From memory disorders to the development of depression: a system approach
Biosystems,
Год журнала:
2025,
Номер
unknown, С. 105440 - 105440
Опубликована: Март 1, 2025
Язык: Английский
Molecular Link Between Psoriasis and Depression—Update on Pathophysiology
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2467 - 2467
Опубликована: Март 10, 2025
Psoriasis
disease
is
a
chronic,
systemic
condition.
Various
epidemiological
studies
have
indicated
connection
between
psoriasis
and
psychiatric
diseases.
It
obvious
that
easily
visible
psoriatic
skin
lesions
cause
stigmatization
of
patients
impact
noticeably
their
life
quality,
increasing
the
risk
anxiety
depressive
disorders.
More
more
attention
recently
being
paid
to
common
pathogenesis
depression.
The
underlying
chronic
inflammation,
depression
also
increasingly
recognized
as
result
neuroinflammation.
Therefore,
complexity
processes
both
entities
implies
need
observe
in
terms
possible
comorbidities,
such
mental
disorders,
regardless
severity
social
stigmatization.
This
study
aims
present
an
update
on
pathophysiology
Язык: Английский
Melatonin’s Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective
Journal of Molecular Neuroscience,
Год журнала:
2024,
Номер
74(4)
Опубликована: Дек. 5, 2024
Язык: Английский
Ketogenic diets in clinical psychology: examining the evidence and implications for practice
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 26, 2024
Introduction
The
application
of
ketogenic
dietary
interventions
to
mental
health
treatments
is
increasingly
acknowledged
within
medical
and
psychiatric
fields,
yet
its
exploration
in
clinical
psychology
remains
limited.
This
article
discusses
the
potential
implications
diets,
traditionally
utilized
for
neurological
disorders,
broader
practices.
Methods
presents
a
perspective
based
on
existing
diet
research
historical
use,
biological
mechanisms,
therapeutic
benefits.
It
examines
these
diets
treatment
their
relevance
practice.
Results
review
informs
psychologists
benefits
introduces
literature
underlying
mechanisms
involved,
such
as
modulation
neurotransmitters,
reduction
inflammation,
stabilization
brain
energy
metabolism,
demonstrating
biopsychosocial
practice
psychology.
Conclusion
By
considering
metabolic
therapies,
can
broaden
scope
integration
provides
care
model
that
incorporates
knowledge
option
care.
emphasizes
need
further
training
support
effective
implementation
this
psychiatry
intervention.
Язык: Английский