Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159276 - 159276

Опубликована: Янв. 1, 2025

Язык: Английский

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Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150

Опубликована: Март 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Язык: Английский

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Macrophage Membrane-Coated Nanoscale Allicin for the Targeted Treatment of Drug-Resistant Bacterial Pneumonia

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Drug-resistant bacterial pneumonia presents a substantial challenge for targeted drug delivery to the infected lung site due existence of mucus and gas-blood barriers. Allicin, renowned its extensive bioactivity, holds promise as an antimicrobial agent. However, unregulated bioavailability restricts both antibacterial anti-inflammatory efficacy. As result, precise targeting infection controlled release is crucial in treatment drug-resistant pneumonia. In this study, we developed macrophage cell membrane-modified nanoallicin composite material (Allicin@MSN@CM) by utilizing membrane modification technology. By harnessing homing ability membranes inflammatory sites, enabled active aggregation nanomaterials during circulation within body. Furthermore, α-hemolysin secreted MRSA bacteria was employed perforate membrane, facilitating on-demand at site. vitro experiments demonstrated that possesses strong properties, alongside good stability biocompatibility. Additionally, mouse model infection, it not only effectively eradicated but also reduced inflammation. This study provides valuable insights into application nanocarriers delivering traditional Chinese medicine address challenges posed

Язык: Английский

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NIR-triggered and Glucose-Powered Hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101557 - 101557

Опубликована: Фев. 5, 2025

Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.

Язык: Английский

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Role of MLIP in burn-induced sepsis and insights into sepsis-associated cancer progression

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Introduction Burn-induced sepsis is a critical clinical challenge marked by systemic inflammation, immune dysregulation, and high mortality. Macrophage-driven inflammatory pathways are central to pathogenesis, while cell metabolic reprogramming plays key role in both cancer progression. Methods Bioinformatics analyses using GEO, TCGA, GTEx datasets identified MLIP-modulated genes linked responses prognosis. In vitro , LPS-stimulated HUVEC cells were used study MLIP’s effects on inflammation macrophage function through viability, ROS levels, cytokine expression, qRT-PCR, immunofluorescence assays. Results associated with immune-related cancer. Epigenetic analysis showed MLIP expression regulated promoter methylation chromatin accessibility. Prognostic revealed impact survival outcomes across types. reduced oxidative stress, hyperactivation. Conclusions regulates immune-metabolic dynamics burn-induced sepsis, influencing activity stress. Its suggests as potential therapeutic target linking modulation Further research evasion tumor metabolism may inform novel strategies.

Язык: Английский

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cGAS-mediated Antibacterial Immunotherapy Against Tuberculosis by Macrophage-Targeted Manganese Dioxide Nanoagonist

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Regulatory role of CD177+ neutrophils in BMP signaling pathway and its implications for inflammatory bowel disease, sepsis, and intestinal tumors

Translational Oncology, Год журнала: 2025, Номер 55, С. 102336 - 102336

Опубликована: Апрель 1, 2025

Язык: Английский

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Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 283, С. 117153 - 117153

Опубликована: Дек. 11, 2024

Язык: Английский

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Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 195, С. 106719 - 106719

Опубликована: Фев. 1, 2024

Molecularly functional drug delivery systems possessed huge potentials to realize novel administration. To explore small molecules modified delivery, a series of mesoporous silica nanoparticles (L-Mal-MSNs, D-Mal-MSNs) were established by grafting molecules. Poorly water-soluble indomethacin (IMC) was chosen load into these carriers as well corresponding control carrier, and further study characteristics effects loaded carriers. The results indicated that all formed hydrogen bonds with drugs can successfully convert crystal phase amorphous state so enhance dissolution compared raw drug. In vivo rat intestinal perfusion demonstrated IMC L-Mal-MSNs performed the fastest absorption while analgesic anti-inflammatory D-Mal-MSNs turned out be best, giving hints D-malic acid exhibited best synergic functions for IMC. herein system is an effective solution strategy current application analgesia outstanding significance.

Язык: Английский

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Advances in nano‐preparations for improving tetrandrine solubility and bioavailability

Archiv der Pharmazie, Год журнала: 2024, Номер 357(10)

Опубликована: Июнь 20, 2024

Abstract Tetrandrine (TET) is a natural bis‐benzylisoquinoline alkaloid isolated from Stephania species with wide range of biological and pharmacologic activities; it mainly serves as an anti‐inflammatory agent or antitumor adjuvant in clinical applications. However, limitations such prominent hydrophobicity, severe off‐target toxicity, low absorption result suboptimal therapeutic outcomes preventing its widespread adoption. Nanoparticles have proven to be efficient devices for targeted drug delivery since drug‐carrying nanoparticles can passively transported the tumor site by enhanced permeability retention (EPR) effects, thus securing niche cancer therapies. Great progress has been made nanocarrier construction TET due their outstanding advantages increased water‐solubility, improved biodistribution blood circulation, reduced irritation, combinational therapy. Herein, we systematically reviewed latest advancements TET‐loaded respective features expectation providing perspective guidelines future research potential applications TET.

Язык: Английский

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