International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(16), С. 8951 - 8951
Опубликована: Авг. 19, 2021
The
choroid
plexus
is
an
important
blood
barrier
that
secretes
cerebrospinal
fluid,
which
essential
for
embryonic
brain
development
and
adult
homeostasis.
OTX2
homeoprotein
a
transcription
factor
critical
remains
highly
expressed
in
plexus.
Through
RNA
sequencing
analyses
of
constitutive
conditional
knockdown
mouse
models,
we
reveal
putative
functional
roles
function,
including
cell
signaling
adhesion,
show
regulates
the
expression
factors
are
secreted
into
notably
transthyretin.
We
also
Otx2
impacts
immune
stress
responses,
affects
splicing,
leading
to
changes
mRNA
isoforms
proteins
implicated
oxidative
response
DNA
repair.
mass
spectrometry
analysis
protein
partners
plexus,
known
non-cell-autonomous
target
regions,
such
as
visual
cortex
subventricular
zone,
identify
targets
involved
chromatin
structure,
processing.
Thus,
retains
regulating
function
homeostasis
throughout
life.
Life Science Alliance,
Год журнала:
2021,
Номер
4(11), С. e202000703 - e202000703
Опубликована: Сен. 20, 2021
Elevated
amyloid
precursor
protein
(APP)
expression
in
the
choroid
plexus
suggests
an
important
role
for
extracellular
APP
metabolites
such
as
sAPPα
cerebrospinal
fluid.
Despite
widespread
App
brain
expression,
we
hypothesized
that
specifically
targeting
could
alter
animal
physiology.
Through
various
genetic
and
viral
approaches
adult
mouse,
show
levels
significantly
impact
proliferation
both
subventricular
zone
hippocampus
dentate
gyrus
neurogenic
niches.
Given
of
Aβ
peptides
Alzheimer
disease
pathogenesis,
also
tested
whether
favoring
production
negatively
affect
niche
functions.
After
AAV5-mediated
long-term
human
mutated
wild-type
mice,
observe
reduced
proliferation,
behavioral
defects
reversal
learning,
deficits
hippocampal
potentiation.
Our
findings
highlight
unique
played
by
regulating
function
suggest
may
provide
a
means
to
improve
alleviate
disease-related
burdens.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Дек. 8, 2022
Adult
neurogenesis
is
the
process
of
differentiation
neural
stem
cells
(NSCs)
into
neurons
and
glial
in
certain
areas
adult
brain.
Defects
can
lead
to
neurodegenerative
diseases,
mental
disorders,
other
maladies.
This
directionally
regulated
by
transcription
factors,
Wnt
Notch
pathway,
extracellular
matrix,
various
growth
factors.
External
factors
like
stress,
physical
exercise,
diet,
medications,
etc.,
affect
gut
microbiota.
The
microbiota
may
NSCs
through
vagal,
immune
chemical
pathways,
pathways.
Traditional
Chinese
medicine
(TCM)
has
been
proven
proliferation
regulate
abundance
metabolites
produced
intestinal
microorganisms.
However,
underlying
mechanisms
which
these
are
not
fully
understood.
In
this
review,
we
describe
recent
evidence
on
role
neurogenesis.
Moreover,
hypothesize
characteristics
microbiota-gut-brain
axis
based
bacterial
phyla,
including
microbiota’s
metabolites,
neuronal
pathways
while
providing
an
outlook
TCM’s
potential
effects
regulating
Journal of Neuroscience Research,
Год журнала:
2019,
Номер
98(5), С. 751 - 753
Опубликована: Дек. 11, 2019
The
authors
have
no
conflict
of
interest
to
declare.
Please
note:
publisher
is
not
responsible
for
the
content
or
functionality
any
supporting
information
supplied
by
authors.
Any
queries
(other
than
missing
content)
should
be
directed
corresponding
author
article.
Fluids and Barriers of the CNS,
Год журнала:
2020,
Номер
17(1)
Опубликована: Март 5, 2020
This
editorial
highlights
advances
in
brain
barrier
and
fluid
research
published
2019,
as
well
addressing
current
controversies
pressing
needs.
Topics
include
recent
related
to:
the
cerebral
endothelium
neurovascular
unit;
choroid
plexus,
arachnoid
membrane;
cerebrospinal
glymphatic
hypothesis;
impact
of
disease
states
on
barriers
fluids;
drug
delivery
to
brain;
translation
preclinical
data
clinic.
also
mourns
loss
two
important
figures
field,
Malcolm
B.
Segal
Edward
G.
Stopa.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(16), С. 8951 - 8951
Опубликована: Авг. 19, 2021
The
choroid
plexus
is
an
important
blood
barrier
that
secretes
cerebrospinal
fluid,
which
essential
for
embryonic
brain
development
and
adult
homeostasis.
OTX2
homeoprotein
a
transcription
factor
critical
remains
highly
expressed
in
plexus.
Through
RNA
sequencing
analyses
of
constitutive
conditional
knockdown
mouse
models,
we
reveal
putative
functional
roles
function,
including
cell
signaling
adhesion,
show
regulates
the
expression
factors
are
secreted
into
notably
transthyretin.
We
also
Otx2
impacts
immune
stress
responses,
affects
splicing,
leading
to
changes
mRNA
isoforms
proteins
implicated
oxidative
response
DNA
repair.
mass
spectrometry
analysis
protein
partners
plexus,
known
non-cell-autonomous
target
regions,
such
as
visual
cortex
subventricular
zone,
identify
targets
involved
chromatin
structure,
processing.
Thus,
retains
regulating
function
homeostasis
throughout
life.
