Extrahippocampal Contributions to Social Memory: The Role of Septal Nuclei

Biological Psychiatry, Год журнала: 2024, Номер 96(11), С. 835 - 847

Опубликована: Май 6, 2024

Язык: Английский

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The role of the lateral septum in neuropsychiatric disease

Journal of Neuroscience Research, Год журнала: 2022, Номер 100(7), С. 1422 - 1437

Опубликована: Апрель 20, 2022

Abstract The lateral septum (LS) is a structure in the midline of brain that interconnected with areas associated stress and feeding. This review highlights role LS anxiety, depression, eating disorders their comorbidity. There prevailing view anxiolytic. finds both anxiolytic anxiogenic. Furthermore, can promote inhibit Given these shared roles, represents common site for comorbidity neuropsychiatric disorders, therefore potential pharmacological target. crucial since currently available treatments are not always effective. Corticotrophin‐releasing factor 2 antagonists drugs treatment anxiety anorexia require further research. other trials binge eating, such as alpha‐adrenergic agonists, may fact food intake. It hoped advancements chemo‐ optogenetic techniques will allow future studies to profile specific neural connections function. information could facilitate our understanding underlying mechanisms, targets, psychiatric conditions.

Язык: Английский

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Projections of hippocampal CA2 pyramidal neurons: Distinct innervation patterns of CA2 compared to CA3 in rodents

Hippocampus, Год журнала: 2023, Номер 33(6), С. 691 - 699

Опубликована: Фев. 28, 2023

Abstract The hippocampus is a center for spatial and episodic memory formation in rodents. Understanding the composition of subregions circuitry maps essential elucidating mechanism recall. For decades, trisynaptic circuit (entorhinal cortex layer II—dentate gyrus — CA3—CA1) has been considered neural network substrate responsible learning memory. Recently, CA2 emerged as an important area hippocampal circuitry, with distinct functions from those CA3. In this article, we review historical definition differential projection patterns between CA3 pyramidal neurons. We provide concise comprehensive map outputs by comparing (1) ipsi versus contra projections, (2) septal temporal (3) lamellar structures

Язык: Английский

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Biased brain and behavioral responses towards kin in males of a communally breeding species

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 9, 2023

In complex social environments, individuals may interact with not only novel and familiar conspecifics but also kin non-kin. The ability to distinguish between conspecific identities is crucial for most animals, yet how the brain processes type animals alter behavior accordingly well known. We examined whether communally breeding spiny mouse (Acomys cahirinus) responds differently that vary in novelty kinship. a group interaction test, we found males can from non-kin, preferentially spend time over To determine kinship status are differentially represented brain, conducted immediate early gene tests, which revealed dorsal, ventral, lateral septum Neither region novelty. Further, did exhibit differences prosocial toward exhibited more than These results suggest species have evolved specialized neural circuitry facilitate bias be affiliative kin, regardless of they or familiar, potentially promote behaviors, thereby facilitating cohesion.

Язык: Английский

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A ventral hippocampal-lateral septum pathway regulates social novelty preference

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 29, 2024

ABSTRACT The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Язык: Английский

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TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G_q/11–G_i/ocoincidence signals of variable strengths

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(20)

Опубликована: Май 11, 2022

Significance Neurons communicate by releasing neurotransmitters, many of which act at G protein–coupled receptors. Although it is well known that q/11 accelerates action potential firing while i/o inhibits firing, how patterns change in response to simultaneous activation and remains elusive, especially because the relative strength versus varies greatly from event event. This study reveals neurons encode distinct messages reflect coincident stimulation activating two ion channels, TRPC4 GIRK. The resulting patterns, composed burst, pause, recovery phases, both occurrence their strengths. With these, we may begin interpret language neurons.

Язык: Английский

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Sex Differences in Aggression Are Paralleled by Differential Activation of the Brain Social Decision-Making Network in Zebrafish

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Фев. 16, 2022

Although aggression is more prevalent in males, females also express aggressive behaviors and specific ecological contexts can be than males. The aim of this work to assess sex differences characterize the patterns neuronal activation social-decision making network (SDMN) response intra-sexual both male female zebrafish. Adult fish were exposed social interaction with a same-sex opponent all behavioral displays, latency, time resolution quantified. After conflict resolution, brains sampled on functional connectivity throughout SDMN assessed by immunofluorescence marker pS6. Results suggest that sexes share similar level motivation for aggression, but encounters show shorter preferential use antiparallel displays instead overt showing reduction putative maladaptive effects. there are no any individual brain area from SDMN, agonistic interactions increased activity most areas sexes. Functional was using bootstrapped adjacency matrices capture co-activation nodes. Male winners overall excitation showed changes inhibition across whereas losers decrease comparison non-interacting control fish. Moreover, centrality analysis revealed shared hubs, as well sex-specific between each condition SDMN. In summary, distinct neural pattern associated experience during fights found sex, suggesting differential consequence experience. Overall, our study adds insights into behavior architecture intrasexual

Язык: Английский

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Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus

Bioscience Reports, Год журнала: 2024, Номер 44(1)

Опубликована: Янв. 1, 2024

Abstract Objective: Combining adeno-associated virus (AAV)-mediated expression of Cre recombinase with genetically modified floxed animals is a powerful approach for assaying the functional role genes in regulating behavior and metabolism. Extensive research diverse cell types tissues using AAV-Cre has shown it can save time avoid developmental compensation as compared driver mouse line crossings. We initially sought to study impact ablation corticotropin-releasing hormone (CRH) paraventricular hypothalamic nucleus (PVN) intracranial injection adult animals. Methods: In present study, we stereotactically injected AAV8-hSyn-Cre or control AAV8-hSyn-GFP both Crh-floxed wild-type PVN assess behavioral metabolic impacts. then used immunohistochemical markers systematically evaluate density peptidergic neurons glial cells. Results: found that delivery one specific preparation led development obesity, hyperphagia, anxiety-like behaviors. This effect occurred independent sex mice. subsequently neuronal death gliosis at site viral vector injections. These deficits were dependent on into PVN. An alternatively sourced did not reproduce same results. Conclusions: Our findings reveal batch could lead cellular toxicity lesions cause robust alterations complicate interpretation Cre-mediated gene knockout highlight need rigorous controls.

Язык: Английский

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Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice

Heliyon, Год журнала: 2024, Номер 10(7), С. e28821 - e28821

Опубликована: Март 30, 2024

The amyloid plaque is a hallmark of Alzheimer's disease. accumulation the precursor protein (APP) in neuronal structure assumed to lead formation through excessive production β-amyloid protein. To study relationship between APP and formation, we histologically analyzed their development different brain regions 3xTg-AD mice, which express Swedish mutated (APP

Язык: Английский

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Lateral septum as a possible regulatory center of maternal behaviors

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105683 - 105683

Опубликована: Апрель 21, 2024

The lateral septum (LS) is involved in controlling anxiety, aggression, feeding, and other motivated behaviors. Lesion studies have also implicated the LS various forms of caring Recently, novel experimental tools provided a more detailed insight into function LS, including specific role distinct cell types their neuronal connections behavioral regulations, which participates. This article discusses regulation different maternal alterations using distributions established hormones such as prolactin, estrogens, neuropeptide oxytocin. It considers distribution neurons activated mothers response to pups activities, well gene expressional LS. Finally, this paper proposes further research directions keep up with rapidly developing knowledge on control brain regions.

Язык: Английский

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