Transcutaneous
vagus
nerve
stimulation
(taVNS)
offers
an
effective,
non-invasive
alternative
to
implantable
and
it
is
considered
be
a
promising
cognitive
modulation
tool.
However,
at
present,
the
effect
of
taVNS
on
working
memory
not
clear,
Simultaneously,
potential
pupillary
responses
stemming
from
require
more
empirical
inquiry.
Herein,
we
investigated
influence
capacity
its
link
during
change
detection
task.
A
sham-controlled,
randomized,
crossover-designed
experiment
was
applied
16
participants.
Within
each
session,
participants
received
Sham
or
Active
for
12
minutes
then
achieved
3
blocks
Each
trial
exceeds
5s.
The
pupil
behavior
were
recorded
We
hypothesized
that
can
improve
performance
task
corresponding
different
numbers
target
stimuli.
For
results,
observed
no
significant
by
but
did
note
distinct
alterations
in
response
(mean
amplitude
extremes)
specified
intervals
These
findings
point
underexplored
avenue
research
into
neural
psychological
processes
affected
provides
new
insight
modulate
capacity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
Abstract
Transcutaneous
vagus
nerve
stimulation
(tVNS)
has
emerged
as
a
promising
technique
to
modulate
autonomic
functions,
and
pupil
dilation
been
recognized
biomarker
for
tVNS-induced
monoaminergic
release.
Nevertheless,
studies
on
the
effectiveness
of
various
tVNS
protocols
have
produced
heterogeneous
results
dilatation
date.
Here,
we
synthesize
existing
evidence
compare
conventional
continuous
pulsed
using
Bayesian
meta-analysis.
To
maintain
living
version,
developed
Shiny
App
with
possibility
incorporate
newly
published
in
future.
Based
systematic
review,
included
18
(N
=
771)
applying
either
or
protocols.
Across
studies,
found
anecdotal
alternative
hypothesis
that
increases
size
(
g
0.14,
95%
CI
[0.001,
0.29],
BF01
2.5).
Separating
according
vs.
revealed
were
driven
by
taVNS
(strong
hypothesis:
0.34,
[0.15,
0.53],
BF10
14.15)
while
provided
strong
null
0.01,
[-0.15,
0.16],
BF01=
20.7).
In
conclusion,
our
meta-analysis
highlights
differential
effects
dilation.
These
findings
underscore
relevance
optimizing
its
use
specific
applications
may
require
modulation
tonic
phasic
responses.
Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 9, 2025
Abstract
Recent
laboratory
research
showed
that
vagus
nerve
stimulation
promotes
fear
extinction,
the
inhibitory
core
mechanism
of
exposure
treatment,
presumably
via
activation
noradrenergic
brain
system.
However,
a
translation
this
technique
to
clinical
practice
is
lacking.
We
therefore
investigated
potential
vagal
inhibit
excessive
responses
and
facilitate
responding
in-vivo
in
individuals
with
specific
phobia.
Spider-phobic
participants
were
subjected
three
standardized
exposures
towards
living
tarantula,
complemented
by
an
vitro
(between
vivo
I
II).
Transcutaneous
auricular
(taVNS)
was
applied
during
in-vitro
exposure,
presenting
pictures
exposed
other
spiders
neutral
tools
laboratory.
Fear
assessed
self-reports
behavioral
avoidance
(in-vivo
exposures),
amygdala-mediated
autonomic
components
(exposure
vitro).
Vagal
facilitated
reduction
across
repeated
exposures.
During
taVNS
inhibited
tachycardia
corrugator
muscle
activity
specifically
response
previously
tarantula
–
effect
became
stronger
increasing
duration.
Psychophysiological
indices
transmission
basolateral
amygdala
elevated
correlated
subsequent
attenuation
avoidance.
Our
results
suggest,
exerts
stimulus-specific
dose-dependent
inhibition
multiple
automatic
fear,
highlighting
as
valuable
adjunct
exposure-based
treatment.
A
translational
action
supported,
proposing
exhibits
its
effects
extinction
circuitry,
particularly
targeting
amygdala.
Brain Sciences,
Год журнала:
2024,
Номер
14(9), С. 875 - 875
Опубликована: Авг. 29, 2024
Transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
is
a
non-invasive
neuromodulation
technique
that
modulates
the
noradrenergic
activity
of
locus
coeruleus
(LC).
Yet,
there
still
uncertainty
about
most
effective
and
reliable
outcome
parameters.
In
double
blind,
sham-controlled
study
including
sample
healthy
young
individuals
(N
=
29),
we
compared
shorter
(3.4
s)
longer
(30
duration
investigated
effects
taVNS
(real
vs.
sham)
on
saliva
samples
(alpha
amylase
cortisol
concentration),
pupil
(pupillary
light
reflex
size
at
rest)
EEG
data
theta
rest,
ERPs
for
No-Go
signals),
cognitive
tasks
(Go/No-Go
Stop
Signal
Tasks).
Salivary
alpha
concentration
was
significantly
increased
in
real
as
to
sham
30
s
condition.
3.4
condition,
found
prolonged
reaction
times
error
rates
Go/No-Go
task
maximum
acceleration
pupillary
reflex.
For
other
outcomes,
no
significant
differences
were
found.
Our
results
show
increases
salivary
alpha-amylase,
which
expected
from
functional
properties
LC.
The
finding
response
short
not
cannot
be
explained
by
an
increase
LC
activity.
We
also
discuss
difficulties
assessing
expression
taVNS-mediated
changes.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Дек. 4, 2024
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
neurodevelopmental
characterized
by
developmental
impairments,
inattention,
motor
hyperactivity,
and
impulsivity.
Currently,
there
no
effective
intervention
that
can
completely
cure
it.
One
of
the
pathogenic
mechanisms
ADHD
involves
abnormalities
in
norepinephrine
(NE)
pathway
within
prefrontal
cortex
(PFC).
In
recent
years,
transcutaneous
auricular
vagus
nerve
stimulation
(taVNS),
non-invasive
neuromodulation
technique,
has
demonstrated
promising
potential
treatment
neurological
psychiatric
disorders.
However,
its
application
management
remains
relatively
unexplored.
Previous
studies
have
shown
taVNS
exerts
therapeutic
effects
on
attention,
cognition,
arousal,
perception,
behavioral
regulation
primarily
through
activating
conduction
pathway,
specifically
targeting
nucleus
tractus
solitarius
-
locus
coeruleus
NE
pathway.
These
findings
led
to
hypothesis
may
be
an
for
ADHD,
with
playing
pivotal
role
this
context.
Therefore,
review
comprehensively
examines
correlation
between
alterations
PFC
mechanism
action
taVNS,
treating
aiming
provide
theoretical
foundation
clinical
applications.
Bioelectronic Medicine,
Год журнала:
2023,
Номер
9(1)
Опубликована: Ноя. 29, 2023
The
vagus
nerve
regulates
inflammation
and
cytokine
release
through
the
inflammatory
reflex.
Recent
pilot
clinical
trials
using
implantable
bioelectronic
devices
have
demonstrated
efficacy
of
stimulation
(VNS)
in
adult
patients
with
bowel
diseases
(IBD)
as
an
alternative
to
drug
treatments.
However,
use
non-invasive
VNS
should
be
interest
adults
IBD
even
more
pediatric
IBD.
In
this
issue
Bioelectronic
Medicine,
Sahn
et
al.
report
that
transcutaneous
auricular
attenuated
signs
symptoms
a
cohort
mild
moderate
thus
opening
new
therapeutic
avenues
management
but
also
patients.
Emotional
experiences
are
a
part
of
our
lives.
The
maladaptive
functioning
an
individual's
emotional
field
can
lead
to
disturbances
various
kinds,
such
as
anxiety
and
depression.
Currently,
there
is
increasing
prevalence
disorders
that
cause
great
human
suffering
high
socio-economic
costs.
processing
has
biological
basis.
major
neuroscientific
theories
emotion
based
on
functioning,
all
them
take
into
account
the
anatomy
function
tenth
cranial
nerve:
vagus
nerve.
nerve
connects
subdiaphragmatic
supradiaphragmatic
areas
modulates
basis
interoceptive
functioning.
Auricular
stimulation
new
innovative
neuromodulation
technique
Several
interventions
have
shown
this
neurostimulation
very
promising
resource
for
treating
disorders.
In
paper,
we
summarise
three
emotion,
explain
what
transauricular
is,
present
arguments
its
use
continued
research.
