Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats

Journal of Neuroscience, Год журнала: 2022, Номер 42(46), С. 8716 - 8728

Опубликована: Окт. 17, 2022

Sensory driven activity during early life is critical for setting up the proper connectivity of sensory cortices. We ask here whether social play behavior, a particular form interaction that highly abundant postweaning development, equally important connections in developing prefrontal cortex (PFC). Young male rats were deprived from with peers period when behavior normally peaks [postnatal day 21–42] (SPD rats), followed by resocialization until adulthood. recorded synaptic currents layer 5 cells slices medial PFC adult SPD and control observed inhibitory reduced slices, while excitatory unaffected. This was associated decrease perisomatic synapses parvalbumin-positive GABAergic cells. In parallel experiments, achieved more reversals probabilistic reversal learning (PRL) task, which depends on integrity PFC, using simplified cognitive strategy than controls. Interestingly, we one daily hour partially rescued behavioral performance PRL, but did not prevent inputs. Our data demonstrate importance unrestricted development skills adulthood show specific alterations can result complex outcome. SIGNIFICANCE STATEMENT study addressed question juvenile contributes to functional found had been (social deprivation - SPD) showed reduction solve task Providing these rats, synapses. results key role emphasize relation between circuit function.

Язык: Английский

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The role of MRS-assessed GABA in human behavioral performance

Progress in Neurobiology, Год журнала: 2022, Номер 212, С. 102247 - 102247

Опубликована: Фев. 8, 2022

Understanding the neurophysiological mechanisms that drive human behavior has been a long-standing focus of cognitive neuroscience. One well-known neuro-metabolite involved in creation optimal behavioral repertoires is GABA, main inhibitory neurochemical brain. Converging evidence from both animal and studies indicates individual variations GABAergic function are associated with performance. In humans, one increasingly used vivo approach to measuring GABA levels through Magnetic Resonance Spectroscopy (MRS). However, implications MRS measures for remain poorly understood. this respect, it yet be determined how within distinct task-related brain regions interest account differences This review summarizes findings cross-sectional baseline MRS-assessed examined their associations performance on various behaviors representing perceptual, motor domains, particular healthy participants across lifespan. Overall, results indicate play pivotal role domains behavior. Even though some converging patterns emerge, challenging draw comprehensive conclusions due task paradigms, targeted interest, implemented techniques reference compounds used. Across all studies, effects point generic partially independent functions refer distinctiveness, interference suppression flexibility. On hand, higher may support distinctiveness neural representations during better coping preferred response tendencies. other lower reduction inhibition, leading These task-dependent appear mediated by age. Nonetheless, additional using emerging advanced methods required further clarify

Язык: Английский

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Regulation of auditory plasticity during critical periods and following hearing loss

Hearing Research, Год журнала: 2020, Номер 397, С. 107976 - 107976

Опубликована: Апрель 20, 2020

Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of auditory pathway have been revealed by examining consequences altered during both developmental critical periods-when facilitates optimization neural circuits concert with external environment-and adulthood-when hearing loss is linked to generation tinnitus. In this review, we summarize research identifying molecular, cellular, circuit-level tonotopic map periods adulthood. These are shared juvenile adult brain along length pathway, where they serve regulate disinhibitory networks, synaptic structure function, as well structural barriers plasticity. Regulation also involves neuromodulatory circuits, which link learning attention, ascending descending cortex lower structures. Further work interplay molecular cellular associating loss-induced tinnitus will continue advance our understanding disorder lead new approaches its treatment.

Язык: Английский

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Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition

Frontiers in Neural Circuits, Год журнала: 2022, Номер 15

Опубликована: Янв. 6, 2022

Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory activity is associated with numerous forms of hearing loss, including noise damage, age-dependent and deafness, as well tinnitus or processing deficits autism spectrum disorder (ASD). In most cases, accompanying are interpreted an active compensatory response absence synaptic activity, increased neural gain control (increased output relative input). We here suggest that also could be related immaturity impairment tonic strength typically develops activity-dependent process ascending experience. these high-SR nerve fibers, which critical for shortest latencies lowest sound thresholds, may have either not matured (possibly congenital deafness autism) dysfunctional after sudden, stressful trauma loss cognitive decline). Fast can occur despite maintained basal hearing. case, nuclei, fast parvalbumin positive interneuron (PV-IN) dendrites diminished frontal brain regions. This leads hippocampal LTP/LTD deficiencies, deficits, unbalanced extra-hypothalamic stress control. Under conditions, a weaken local neuronal coupling homeostatic vascular responses required metabolic support adjustment processes. emphasize need distinguish two states excitatory/inhibitory imbalance disorders: (i) conditions preserved sustained strength, following deprivation maintain precise through memory linked, transient disinhibition enhanced spiking fidelity (central gain⇑) (ii) critically part synchronization over broader frequency range, reliability gain⇓). latter stage mutually reinforces processes, increasing risks canonical dementia syndromes.

Язык: Английский

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A Large-Scale Study of the Relationship Between Degree and Type of Hearing Loss and Recognition of Speech in Quiet and Noise

Ear and Hearing, Год журнала: 2024, Номер 45(4), С. 915 - 928

Опубликована: Фев. 23, 2024

Objectives: Understanding speech in noise (SIN) is the dominant complaint of individuals with hearing loss. For decades, default test perception routine audiologic assessment has been monosyllabic word recognition quiet (WRQ), which does not directly address patient concerns, leading some to advocate that measures SIN should be integrated into practice. However, very little known regard how abilities are affected by different types Here, we examine performance on clinical WRQ and a large base consisting variety loss types, including conductive (CHL), mixed (MHL), sensorineural (SNHL) losses. Design: In retrospective study, examined data from 5593 patients (51% female) who underwent audiometric at Stanford Ear Institute. All completed pure-tone audiometry, testing monaural WRQ, QuickSIN. Patient ages ranged 18 104 years (average = 57). The average age for classifications was 51.1 (NH), 48.5 64.2 68.5 (SNHL), respectively. Generalized linear mixed-effect models quartile regression were used determine relationship between type severity speech-recognition outcome measures. Results: Patients CHL had similar normal both QuickSIN, regardless severity. MHL or SNHL, scores remained largely excellent increasing until moderately severe worse. contrast, QuickSIN signal ratio (SNR) losses showed an orderly systematic decrease as degree became more severe. This effect scaled data, threshold-QuickSIN relationships absent CHL, becoming increasingly stronger strongest SNHL. variability these suggests only 57% variance scores, 50% SNR losses, could accounted thresholds. would differentiated shown potentially differentiable scores. Conclusions: this set, decreased increased. deficits degrees yielded considerable even after classifying according their loss, thresholds account portion abilities, particularly noise. These results consistent idea variables such cochlear health aging add explanatory power over audibility alone.

Язык: Английский

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Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex

Frontiers in Cellular Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Апрель 21, 2020

Plasticity is a fundamental property of the nervous system that enables its adaptations to ever-changing environment. Heightened plasticity typical for developing circuits facilitates their robust experience-driven functional maturation. This wanes during adolescence permit stabilization mature brain function, but abundant evidence supports adult exhibit both transient and long-term experience-induced plasticity. Sensory-driven cortical has been extensively studied throughout life span main distinction between development adulthood arising from these studies concept passive exposure relevant information sufficient drive early in life, while higher-order attentional mechanisms are necessary plastic changes adults. Recent work primary visual auditory cortices began define circuit govern processes enable continuous adaptation environment, with disinhibition emerging as common prerequisite developmental Drawing systems, this review summarizes recent reports on cellular brains emphasizes similarities differences them. Benefits distinct used at different ages discussed context sensory learning, well relationship maladaptive neurodevelopmental disorders. Knowledge gaps avenues future highlighted, will hopefully motivate research areas, particularly those pertaining learning complex skills development.

Язык: Английский

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Inhibition in the auditory cortex

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 132, С. 61 - 75

Опубликована: Ноя. 22, 2021

The auditory system provides us with extremely rich and precise information about the outside world. Once a sound reaches our ears, acoustic it carries travels from cochlea all way to cortex, where its complexity nuances are integrated. In functional circuits formed by subpopulations of intermingled excitatory inhibitory cells. this review, we discuss recent evidence specific contributions neurons in processing integration. We first examine intrinsic properties three main classes interneurons cortex. Then, describe how inhibition shapes responsiveness cortex sound. Finally, contribute sensation perception sounds. Altogether, review points out crucial role cortical integrating context, history, or meaning It also highlights open questions be addressed for increasing understanding staggering leading subtlest perception.

Язык: Английский

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Impact of Otitis Media With Effusion in Early Age on Auditory Processing Abilities in Children: A Systematic Review and Meta-Analysis

Ear Nose & Throat Journal, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Objective: Early-onset otitis media with effusion (OME) can affect the development of auditory nervous system and thus lead to processing abnormalities. This study aims review effect childhood OME on abilities in children. Methods: A systematic literature, restricted English language from 1990 2022 was conducted using search engines like PubMed, Embase, Google Scholar. After selecting articles following predefined inclusion exclusion criteria, data were extracted meta-analysis performed. Results: total 10 met criteria. Children a history had poorer performance most behavioral electrophysiological tests. Pooled analysis various tests such as gap noise test, frequency pattern test (verbal nonverbal), latencies brainstem response-I, V, I III, V showed difference between 2 groups. Conclusion: Childhood significantly

Язык: Английский

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Auditory processing remains sensitive to environmental experience during adolescence in a rodent model

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Май 24, 2022

Abstract Elevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable circuits are vulnerable environmental influences that may disrupt behavioral maturation. While these risks well-established prior sexual maturity (i.e., critical periods), the degree of vulnerability adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning gerbils, ask whether maturation disrupted. We find adolescent HL causes a significant perceptual deficit can be attributed degraded auditory cortex processing, as assessed with wireless single neuron recordings within-session population-level analyses. Finally, brain slices from animals reveal synaptic deficits distinct those typically observed after period deprivation. Taken together, results show diminished sensory experience cause long-lasting originate, part, dysfunctional cortical circuit.

Язык: Английский

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Social play behavior shapes the development of prefrontal inhibition in a region-specific manner

Cerebral Cortex, Год журнала: 2023, Номер 33(15), С. 9399 - 9408

Опубликована: Июнь 14, 2023

Experience-dependent organization of neuronal connectivity is critical for brain development. We recently demonstrated the importance social play behavior developmental fine-tuning inhibitory synapses in medial prefrontal cortex rats. When these effects experience occur and if this happens uniformly throughout currently unclear. Here we report important temporal regional heterogeneity impact on development excitatory neurotransmission orbitofrontal cortex. recorded layer 5 pyramidal neurons from juvenile (postnatal day (P)21), adolescent (P42), adult (P85) rats after deprivation (between P21 P42). The subregions followed different trajectories. On P21, synaptic input was higher than Social did not affect currents, but reduced transmission both Intriguingly, reduction occurred during deprivation, whereas only became manifested deprivation. These data reveal a complex interaction between specific trajectories subregions.

Язык: Английский

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