Biosensors,
Год журнала:
2024,
Номер
14(7), С. 354 - 354
Опубликована: Июль 20, 2024
A
non-invasive
and
non-pharmacological
approach
is
evaluated
for
the
proprioceptive
postural
improvement
of
PD
subjects.
The
authors
effectiveness
a
class
I
medical
device
according
to
EU
regulation
745/2017
designed
develop
mechanism
action
based
on
modulation
potentials,
which
occurs
in
prevalent
pathways
afferent
peripheral
nervous
system
efferent
subjects
with
spasticity.
present
observational
study,
structured
double-blind
randomized
manner,
therefore,
had
main
aim
evaluating
ability
improve
motor
function
patients.
This
study
was
instrumented
gait
analysis
performed
Timed
Up
Go
(TUG)
test
procedure,
as
well
using
fall
risk
assessment
accordance
Berg
Balance
Scale
(BBS)
procedures.
involved
25
participants
active
group
(no
placebo)
non-active
(placebo),
latter
whom
non-functional
devices
were
applied,
but
every
respect
identical
functional
applied
patients
no
placebo
group.
Data
conducted
statistical
methodologies
statistics,
significance
results
observed
samples
interdependence
between
measured
variables.
remodulation
potentials
preliminary
through
numerical
modeling
Hodgkin–Huxley
axon,
modified
by
introducing
influence
capacitive
clinical
tests
into
validated
model
target
dielectric
properties
materials
constituting
passive
sensor.
use
neuromodulation
promises
observable
improvements
among
patients,
including
increased
limb
mobility
greater
stability.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Parkinson’s
disease
is
a
progressive
neurodegenerative
that
destroys
substantia
nigra
dopaminergic
neurons,
causing
tremors,
bradykinesia,
rigidity,
and
postural
instability.
Current
treatment
approaches
primarily
focus
on
symptom
management,
employing
pharmacological,
non-pharmacological,
surgical
methods.
However,
these
treatments
often
result
in
fluctuating
symptoms,
side
effects,
progression.
Here,
the
authors
have
reviewed
emerging
field
of
nanomedicine
as
promising
path
for
treatment,
emphasizing
its
potential
to
overcome
limitations
traditional
therapies.
Nanomedicine
utilizes
nanoparticles
targeted
drug
delivery,
leveraging
their
small
size
high
surface
area
volume
ratio
cross
blood-brain
barrier
deliver
therapeutic
agents
directly
affected
brain
regions.
Various
nanoparticles,
including
lipid-based,
polymeric,
metallic,
carbon-based,
shown
treatment.
Additionally,
nanocarrier
systems
like
liposomes,
nanogels,
dendrimers,
solid
lipid
offer
controlled
sustained
release
agents,
enhancing
bioavailability
reducing
effects.
This
review
provides
insights
into
pathophysiology
disease,
highlighting
mechanisms
neurodegeneration,
role
alpha-synuclein,
disruption
pathways.
It
further
discusses
application
gene
therapy
conjunction
with
interventions.
Expert Opinion on Biological Therapy,
Год журнала:
2024,
Номер
24(8), С. 773 - 785
Опубликована: Июль 27, 2024
In
gene
therapy
with
adeno-associated
virus
(AAV)
vectors
for
diseases
of
the
central
nervous
system,
can
be
administered
into
blood
vessels,
cerebrospinal
fluid
space,
or
brain
parenchyma.
When
transfer
to
a
large
area
is
required,
first
two
methods
are
used,
but
in
which
local
expected
effective,
directly
Medicina,
Год журнала:
2024,
Номер
60(9), С. 1384 - 1384
Опубликована: Авг. 24, 2024
Nanomedicine
is
a
newer,
promising
approach
to
promote
neuroprotection,
neuroregeneration,
and
modulation
of
the
blood–brain
barrier.
This
review
includes
integration
various
nanomaterials
in
neurological
disorders.
In
addition,
gelatin-based
hydrogels,
which
have
huge
potential
due
biocompatibility,
maintenance
porosity,
enhanced
neural
process
outgrowth,
are
reviewed.
Chemical
modification
these
especially
with
guanidine
moieties,
has
shown
improved
neuron
viability
underscores
tailored
biomaterial
design
applications.
further
discusses
strategies
modulate
barrier—a
factor
critically
associated
effective
delivery
drugs
central
nervous
system.
These
advances
bring
supportive
solutions
solving
conditions
innovative
therapies
for
their
treatment.
Nanomedicine,
as
applied
neuroscience,
presents
significant
leap
forward
new
therapeutic
that
might
help
raise
treatment
management
disorders
much
better
levels.
Our
aim
was
summarize
current
state-of-knowledge
this
field.
Brain stimulation,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Highlights•Cortical
gamma
oscillations
often
entrain
with
pallidal
and
subthalamic
stimulation•Entraining
levodopa-induced
diminishes
their
prodyskinetic
effect•Levodopa-induced
oscillation
peak
frequency
variance
reduces
when
entrainedAbstractBackgroundIn
Parkinson's
disease,
invasive
brain
recordings
show
that
dopaminergic
medication
can
induce
narrowband
rhythms
in
the
motor
cortex
nucleus,
which
co-fluctuate
dyskinesia
scores.
Deep
stimulation
these
to
a
subharmonic
frequency.
However,
incidence
of
entrainment
during
chronic
therapeutic
stimulation,
its
relationship
basal
ganglia
site,
effect
on
remain
unknown.ObjectiveDetermine
whether
behavioral
effects
statistical
properties
are
altered
entrained
deep
stimulation.MethodsWe
used
sensing-enabled
stimulator
system,
attached
both
(n=15)
or
(n=5)
leads,
record
993
hours
multisite
field
potentials,
656
recorded
prior
initiating
stimulation.
13
subjects
(20
hemispheres)
disease
(1/13
female,
mean
age
59±9
years)
streamed
data
while
at
home
usual
antiparkinsonian
medication.
Recordings
occurred
least
five
months
after
stimulation.ResultsCortical
were
detected
4/5
hemispheres
undergoing
12/15
Entraining
either
site
reduced
effects.
Cortical
had
frequency,
increased
spectral
power,
higher
power
than
oscillations.ConclusionStimulation-entrained
functionally
physiologically
distinct
from
occur
absence
Understanding
discrepancies
between
types
may
improve
programming
protocols.
Biological Cybernetics,
Год журнала:
2025,
Номер
119(2-3)
Опубликована: Март 20, 2025
Abstract
This
study
develops
an
event-based,
energy-efficient
control
strategy
for
desynchronizing
coupled
neuronal
networks
using
optimal
theory.
Inspired
by
phase
resetting
techniques
in
Parkinson’s
disease
treatment,
we
incorporate
stochasticity
of
the
system’s
dynamics
into
deterministic
models
to
address
neural
system
intrinsic
noise.
We
use
advanced
computational
solver
nonlinear
stochastic
partial
differential
equations
solve
Hamilton–Jacobi–Bellman
equation
via
level
set
methods
a
single
neuron
model;
this
allows
us
find
inputs
which
drive
close
phaseless
set.
When
applied
networks,
these
achieve
effective
randomization
spike
timing,
leading
significant
network
desynchronization.
Compared
its
counterpart,
our
method
can
considerable
energy
savings.
The
event-based
minimizes
unnecessary
charge
transfer,
potentially
extending
implanted
stimulator
battery
life
while
maintaining
robustness
against
variations
coupling
strengths
and
heterogeneities.
These
findings
highlight
potential
developing
neurostimulation
with
implications
deep
brain
stimulation
protocols.
presented
framework
could
also
be
other
domains
problems
are
prevalent.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
Dystonia
is
a
movement
disorder
defined
by
involuntary,
sustained,
or
intermittent
muscle
contractions,
typically
described
as
repetitive,
twisted
postures.
Dyskinetic
cerebral
palsy
the
most
common
cause
of
acquired
dystonia
in
children.
patients
with
can
affect
function,
pain,
comfort,
and
quality
life.
Pharmacological
treatment
often
unsatisfactory.
Deep
brain
stimulation
(DBS),
surgical
neuromodulation
therapy,
has
been
reported
to
be
an
effective
for
palsy.
Multiple
clinical
variables
have
associated
improved
outcomes,
including
diminished
disease
duration,
decreased
age,
heightened
frequency
irregular
intraoperative
GPi
microelectrode
firing,
absence
enduring
skeletal
abnormalities.
These
characteristics
may
operate
positive
prognostic
indications
therapeutic
effectiveness
DBS.
Conversely,
large
lesions,
intensity
dystonia,
accompanying
spasticity
hinder
efficacy.
At
present,
there
are
no
eligibility
requirements
Evidence
indicates
that
DBS
not
only
facilitates
motor
enhancements
but
also
significantly
improves
