Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 20, 2024
Abstract
Somatoform
traits,
which
manifest
as
persistent
physical
symptoms
without
a
clear
medical
cause,
are
prevalent
and
pose
challenges
to
clinical
practice.
Understanding
the
genetic
basis
of
these
disorders
could
improve
diagnostic
therapeutic
approaches.
With
publicly
available
summary
statistics,
we
conducted
multivariate
genome-wide
association
study
(GWAS)
multi-omic
analysis
four
somatoform
traits—fatigue,
irritable
bowel
syndrome,
pain
intensity,
health
satisfaction—in
799,429
individuals
genetically
similar
Europeans.
GWAS
identified
134
loci
significantly
associated
with
common
factor,
including
44
not
significant
in
input
8
novel
for
traits.
Gene-property
analyses
highlighted
enrichment
genes
involved
synaptic
transmission
enriched
gene
expression
12
brain
tissues.
Six
genes,
members
CD300
family,
had
putatively
causal
effects
mediated
by
protein
abundance.
There
was
substantial
polygenic
overlap
(76–83%)
between
externalizing,
internalizing,
general
psychopathology
factors.
scores
were
obesity,
Type
2
diabetes,
tobacco
use
disorder,
mood/anxiety
independent
biobanks.
Drug
repurposing
suggested
potential
targets,
MEK
inhibitors.
Mendelian
randomization
indicated
protective
gut
microbiota,
includingRuminococcus
bromii.
These
biological
insights
provide
promising
avenues
treatment
development.
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Май 10, 2024
In
modern
times
there
is
increasing
acceptance
that
music-based
interventions
are
useful
aids
in
the
clinical
treatment
of
a
range
neurological
and
psychiatric
conditions,
including
helping
to
reduce
perception
pain.
Indeed,
belief
music,
whether
listening
or
performing,
can
alter
human
pain
experiences
has
long
history,
dating
back
ancient
Greeks,
its
potential
healing
properties
have
been
appreciated
by
indigenous
cultures
around
world.
The
subjective
experience
acute
chronic
complex,
influenced
many
intersecting
physiological
psychological
factors,
it
therefore
be
expected
impact
music
therapy
on
may
vary
from
one
situation
another,
person
another.
Where
persists
becomes
chronic,
aberrant
central
processing
key
feature
associated
with
ongoing
experience.
Nonetheless,
beneficial
effects
exposure
relief
reported
across
wide
shown
effective
neonates,
children
adults.
this
comprehensive
review
we
examine
various
neurochemical,
factors
underpin
experience,
potentially
operate
at
levels
–
periphery,
spinal
cord,
brainstem,
limbic
system
multiple
areas
cerebral
cortex.
We
discuss
extent
which
these
individually
combination,
influence
how
affects
both
quality
intensity
pain,
noting
remains
controversy
about
respective
roles
diverse
peripheral
processes
play
Better
understanding
mechanisms
underlie
music’s
together
insights
into
should
aid
developing
more
synergistic
approaches
when
combined
treatments.
ubiquitous
nature
also
facilitates
application
therapeutic
environment
daily
life,
for
individual
social
benefit.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Март 3, 2025
Background
Chronic
pain
is
a
common
non-motor
symptom
of
Parkinson’s
disease
(PD)
that
significantly
impacts
patients’
quality
life,
but
its
neural
mechanisms
remain
poorly
understood.
This
study
investigated
changes
in
spontaneous
neuronal
activity
and
functional
connectivity
(FC)
associated
with
chronic
PD
patients.
Methods
The
included
41
patients
(PDP),
without
(nPDP),
29
healthy
controls.
Pain
severity
was
assessed
using
the
visual
analog
scale
(VAS).
Resting-state
fMRI
images
were
used
to
measure
amplitude
low-frequency
fluctuations
(ALFF)
as
an
indicator
regional
brain
activity.
Subsequently,
FC
analysis
performed
evaluate
synchronization
between
ALFF-identified
regions
entire
brain.
Results
Compared
nPDP
patients,
PDP
exhibited
decreased
ALFF
right
putamen,
increased
motor
regions,
including
superior
frontal
gyrus/supplementary
area
left
paracentral
lobule/primary
cortex.
Additionally,
diminished
putamen-based
midbrain,
anterior
cingulate
cortex,
orbitofrontal
middle
gyrus,
temporal
posterior
cerebellar
lobe.
correlation
revealed
values
putamen
negatively
VAS
scores
Conclusion
demonstrates
reduced
disrupted
involved
perception
modulation,
highlighting
critical
role
dopaminergic
degeneration
development
maintenance
PD.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
In
this
study
we
examined
the
neuronal
mechanisms
of
chronic
pain
by
recruiting
a
participant
diagnosed
with
New
Daily
Persistent
Headache
(NDPH),
who
had
reliable
characteristic
in
that
his
baseline
could
be
immediately
and
consistently
modulated
(partially
relieved
or
aggravated)
applying
deep
pressure
to
specific
locations
along
face
head.
We
sought
map
brain
regions
responsive
modulations
using
functional
magnetic
resonance
imaging
(fMRI).
constructed
MRI-compatible
3D-printed
masks
skull
plates
affixed
syringe
plungers
apply
remove
discrete
face/head
locations.
Using
On/Off
block
paradigms,
collected
fMRI
data
across
nine
sessions
while
pressing
on
either
increased,
decreased,
no
effect
pain.
Although
displacement
artifacts
precluded
use
relief
point
data,
did
reveal
five
showed
significantly
increased
responses
when
stimulating
aggravated
headache
pain,
including
right
anterior
insula,
bilateral
inferior
parietal
lobule
(IPL)
foci,
plus
cerebellar
(lobule
VIIIb).
Resting-state
connectivity
MRI
analyses,
structural
vector
autoregression
(Granger
causality),
somatosensory-related
network
further
revealed
effective
(positive
paths)
from
left
IPL
these
two
positive
paths
IPL.
This
cortical
circuit
was
coupled
foci
participant’s
anatomically
derived
periaqueductal
gray
(PAG)
region.
Moreover,
days
greater
degrees
PAG
exhibited
negative
cerebellum,
respectively,
thereby
revealing
additional
psychophysiological
attributes
circuit.
Together,
results
not
only
identified
candidate
targets
for
patient-customized
neuromodulation
therapies
but
also
novel
testable
model
regarding
potential
underlying
one
form
neuropathic
perception.
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Май 16, 2025
Meditation
is
a
widely
recognized
umbrella
term
encompassing
diverse
range
of
techniques
with
shared
foundational
characteristics,
celebrated
for
their
potential
to
alleviate
mental
and
physical
challenges.
While
subjective
reports
behavioral
studies
have
long
highlighted
meditation’s
benefits,
recent
neuroscientific
research
has
sought
provide
tangible
physiological
evidence
its
efficacy
as
non-invasive
intervention
managing
pain.
This
review
examines
the
neurophysiological
mechanisms
by
which
meditation
influences
brain
activity
in
response
both
acute
chronic
pain
experiences.
Drawing
on
findings
from
functional
magnetic
resonance
imaging
(fMRI)
studies,
general
models
are
categorized
explain
how
alters
cortical
responses
naïve
expert
practitioners
when
exposed
stimuli.
First,
we
discuss
three
major
components
processing
analyze
affects
each
stage.
Next,
identify
key
regions
consistently
implicated
modulation
through
meditation,
elucidating
roles
perception
regulation.
Finally,
propose
framework
differentiating
based
distinct
effects
These
insights
significant
implications
understanding
therapeutic
various
management,
particularly
conditions.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 29, 2024
Abstract
Somatoform
traits,
which
manifest
as
persistent
physical
symptoms
without
a
clear
medical
cause,
are
prevalent
and
pose
challenges
to
clinical
practice.
Understanding
the
genetic
basis
of
these
disorders
could
improve
diagnostic
therapeutic
approaches.
With
publicly
available
summary
statistics,
we
conducted
multivariate
genome-wide
association
study
(GWAS)
multi-omic
analysis
four
somatoform
traits—fatigue,
irritable
bowel
syndrome,
pain
intensity,
health
satisfaction—in
799,429
individuals
genetically
similar
Europeans.
Using
genomic
structural
equation
modeling,
GWAS
identified
134
loci
significantly
associated
with
common
factor,
including
44
not
significant
in
input
8
novel
for
traits.
Gene-property
analyses
highlighted
an
enrichment
genes
involved
synaptic
transmission
enriched
gene
expression
12
brain
tissues.
Six
genes,
members
CD300
family,
had
putatively
causal
effects
mediated
by
protein
abundance.
There
was
substantial
polygenic
overlap
(76-83%)
between
externalizing,
internalizing,
general
psychopathology
factors.
scores
were
most
strongly
obesity,
Type
2
diabetes,
tobacco
use
disorder,
mood/anxiety
independent
biobanks.
Drug
repurposing
suggested
potential
targets,
MEK
inhibitors.
Mendelian
randomization
indicated
potentially
protective
gut
microbiota,
Ruminococcus
bromii
.
These
biological
insights
provide
promising
avenues
treatment
development.
Brain Sciences,
Год журнала:
2024,
Номер
14(11), С. 1102 - 1102
Опубликована: Окт. 30, 2024
There
is
a
subset
of
patients
with
pain
who
become
worse
after
exercise.
To
explore
this,
we
examined
the
responses
people
chronic
primary
to
standardized
high
intensity
exercise
protocol
used
induce
delayed
onset
muscle
soreness
(DOMS).
