The psychophysiology of music-based interventions and the experience of pain

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

In modern times there is increasing acceptance that music-based interventions are useful aids in the clinical treatment of a range neurological and psychiatric conditions, including helping to reduce perception pain. Indeed, belief music, whether listening or performing, can alter human pain experiences has long history, dating back ancient Greeks, its potential healing properties have been appreciated by indigenous cultures around world. The subjective experience acute chronic complex, influenced many intersecting physiological psychological factors, it therefore be expected impact music therapy on may vary from one situation another, person another. Where persists becomes chronic, aberrant central processing key feature associated with ongoing experience. Nonetheless, beneficial effects exposure relief reported across wide shown effective neonates, children adults. this comprehensive review we examine various neurochemical, factors underpin experience, potentially operate at levels – periphery, spinal cord, brainstem, limbic system multiple areas cerebral cortex. We discuss extent which these individually combination, influence how affects both quality intensity pain, noting remains controversy about respective roles diverse peripheral processes play Better understanding mechanisms underlie music’s together insights into should aid developing more synergistic approaches when combined treatments. ubiquitous nature also facilitates application therapeutic environment daily life, for individual social benefit.

Язык: Английский

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Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102519 - 102519

Опубликована: Сен. 1, 2024

Язык: Английский

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Cerebellar Roles in Motor and Social Functions and Implications for ASD

The Cerebellum, Год журнала: 2024, Номер 23(6), С. 2564 - 2574

Опубликована: Июль 17, 2024

Язык: Английский

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Exploring Psychological Factors and Brain Alterations in Functional Anorectal Pain Patients: Insights From Multimodal Magnetic Resonance Imaging Investigations

Neurogastroenterology & Motility, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

ABSTRACT Background Functional anorectal pain (FAP) is classified as one of the disorders gut‐brain interaction (DGBI). It involves impairments afferents and disrupted communication. However, neuroimaging studies focused on FAP are lacking. Methods A total 25 patients 18 healthy controls (HC) underwent structural magnetic resonance imaging (MRI), diffusion tensor (DTI), resting‐state functional MRI (rs‐fMRI) scans, collection demographic data, mental health assessment scales questionnaires. Voxel‐based morphometry (VBM), tract‐based spatial statistics (TBSS), regional homogeneity (ReHo), amplitude low‐frequency fluctuations (ALFF) were utilized to analyze data. Correlation analyses conducted explore relationships between findings clinical symptoms. Key Results exhibited higher levels anxiety, depression scores lower sleep quality compared HC. VBM analysis revealed increased gray matter volume (GMV) in bilateral fusiform, right parahippocampal, inferior temporal gyrus (ITG), decreased GMV superior frontal (SFG), left middle (MFG), (IFG), Calcarine, occipital (MOG), (MTG) patients. TBSS showed fractional anisotropy (FA) longitudinal fasciculus (SLF), anterior thalamic radiation (ATR), forceps minor Additionally, ALFF cerebellum ReHo MFG observed Conclusions Inferences These a worse psychological condition suggested neuroanatomical neurofunctional alterations associated with processing, emotion regulation, cognitive control

Язык: Английский

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Altered functional activity and connectivity in Parkinson’s disease with chronic pain: a resting-state fMRI study

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 3, 2025

Background Chronic pain is a common non-motor symptom of Parkinson’s disease (PD) that significantly impacts patients’ quality life, but its neural mechanisms remain poorly understood. This study investigated changes in spontaneous neuronal activity and functional connectivity (FC) associated with chronic PD patients. Methods The included 41 patients (PDP), without (nPDP), 29 healthy controls. Pain severity was assessed using the visual analog scale (VAS). Resting-state fMRI images were used to measure amplitude low-frequency fluctuations (ALFF) as an indicator regional brain activity. Subsequently, FC analysis performed evaluate synchronization between ALFF-identified regions entire brain. Results Compared nPDP patients, PDP exhibited decreased ALFF right putamen, increased motor regions, including superior frontal gyrus/supplementary area left paracentral lobule/primary cortex. Additionally, diminished putamen-based midbrain, anterior cingulate cortex, orbitofrontal middle gyrus, temporal posterior cerebellar lobe. correlation revealed values putamen negatively VAS scores Conclusion demonstrates reduced disrupted involved perception modulation, highlighting critical role dopaminergic degeneration development maintenance PD.

Язык: Английский

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Cortical networks activated when aggravating baseline chronic pain of an individual with New Daily Persistent Headache: A Case Study

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

In this study we examined the neuronal mechanisms of chronic pain by recruiting a participant diagnosed with New Daily Persistent Headache (NDPH), who had reliable characteristic in that his baseline could be immediately and consistently modulated (partially relieved or aggravated) applying deep pressure to specific locations along face head. We sought map brain regions responsive modulations using functional magnetic resonance imaging (fMRI). constructed MRI-compatible 3D-printed masks skull plates affixed syringe plungers apply remove discrete face/head locations. Using On/Off block paradigms, collected fMRI data across nine sessions while pressing on either increased, decreased, no effect pain. Although displacement artifacts precluded use relief point data, did reveal five showed significantly increased responses when stimulating aggravated headache pain, including right anterior insula, bilateral inferior parietal lobule (IPL) foci, plus cerebellar (lobule VIIIb). Resting-state connectivity MRI analyses, structural vector autoregression (Granger causality), somatosensory-related network further revealed effective (positive paths) from left IPL these two positive paths IPL. This cortical circuit was coupled foci participant’s anatomically derived periaqueductal gray (PAG) region. Moreover, days greater degrees PAG exhibited negative cerebellum, respectively, thereby revealing additional psychophysiological attributes circuit. Together, results not only identified candidate targets for patient-customized neuromodulation therapies but also novel testable model regarding potential underlying one form neuropathic perception.

Язык: Английский

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Trigeminal Semilunar Ganglion Stimulation Modulates Default Mode Network Connectivity in Trigeminal Neuralgia

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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fMRI-based explanations for how meditation could modulate pain processing

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 16, 2025

Meditation is a widely recognized umbrella term encompassing diverse range of techniques with shared foundational characteristics, celebrated for their potential to alleviate mental and physical challenges. While subjective reports behavioral studies have long highlighted meditation’s benefits, recent neuroscientific research has sought provide tangible physiological evidence its efficacy as non-invasive intervention managing pain. This review examines the neurophysiological mechanisms by which meditation influences brain activity in response both acute chronic pain experiences. Drawing on findings from functional magnetic resonance imaging (fMRI) studies, general models are categorized explain how alters cortical responses naïve expert practitioners when exposed stimuli. First, we discuss three major components processing analyze affects each stage. Next, identify key regions consistently implicated modulation through meditation, elucidating roles perception regulation. Finally, propose framework differentiating based distinct effects These insights significant implications understanding therapeutic various management, particularly conditions.

Язык: Английский

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Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 29, 2024

Abstract Somatoform traits, which manifest as persistent physical symptoms without a clear medical cause, are prevalent and pose challenges to clinical practice. Understanding the genetic basis of these disorders could improve diagnostic therapeutic approaches. With publicly available summary statistics, we conducted multivariate genome-wide association study (GWAS) multi-omic analysis four somatoform traits—fatigue, irritable bowel syndrome, pain intensity, health satisfaction—in 799,429 individuals genetically similar Europeans. Using genomic structural equation modeling, GWAS identified 134 loci significantly associated with common factor, including 44 not significant in input 8 novel for traits. Gene-property analyses highlighted an enrichment genes involved synaptic transmission enriched gene expression 12 brain tissues. Six genes, members CD300 family, had putatively causal effects mediated by protein abundance. There was substantial polygenic overlap (76-83%) between externalizing, internalizing, general psychopathology factors. scores were most strongly obesity, Type 2 diabetes, tobacco use disorder, mood/anxiety independent biobanks. Drug repurposing suggested potential targets, MEK inhibitors. Mendelian randomization indicated potentially protective gut microbiota, Ruminococcus bromii . These biological insights provide promising avenues treatment development.

Язык: Английский

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Delayed Recovery After Exercise-Induced Pain in People with Chronic Widespread Muscle Pain Related to Cortical Connectivity

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1102 - 1102

Опубликована: Окт. 30, 2024

There is a subset of patients with pain who become worse after exercise. To explore this, we examined the responses people chronic primary to standardized high intensity exercise protocol used induce delayed onset muscle soreness (DOMS).

Язык: Английский

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