Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Опубликована: Окт. 9, 2023

Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) parieto-occipital junction (LPOJ). After defining thousands of sulci a young adult cohort, we revised previous LPC/LPOJ sulcal landscape to include four previously overlooked, small, shallow, variable sulci. One these (ventral supralateral occipital sulcus, slocs-v) is present nearly every hemisphere morphologically, architecturally, functionally dissociable from neighboring A data-driven, model-based approach, relating depth behavior further revealed that morphology only subset including slocs-v, related performance on spatial orientation task. Our findings build classic neuroanatomical theories identify targets for future “precision imaging” studies exploring among brain structure, function, cognitive abilities individual participants.

Язык: Английский

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Sulcal variability in anterior lateral prefrontal cortex contributes to variability in reasoning performance among young adults

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 12, 2023

Identifying structure-function correspondences is a major goal among biologists, cognitive neuroscientists, and brain mappers. Recent studies have identified relationships between performance on tasks the presence or absence of small, shallow indentations, sulci, human brain. Building previous finding that one such sulcus in left anterior lateral prefrontal cortex (aLPFC) was related to reasoning task children adolescents, we tested whether this relationship extended different sample, age group, task. As predicted, aLPFC sulcus-the ventral para-intermediate frontal sulcus-was also associated with higher scores young adults (ages 22-36). These findings not only direct developmental, but evolutionary relevance-as recent work shows pimfs-v exceedingly rare chimpanzees. Thus, novel cognitive, evolutionarily relevant feature should be considered future examining how complex multiscale anatomical functional features give rise abstract thought.

Язык: Английский

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Better long-term learning ability is predicted by higher surface folding of the human premotor cortex

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 21, 2023

Abstract The capacity to learn enabled the human species adapt various challenging environmental conditions and pass important achievements on next generation. A growing body of research suggests links between neocortical folding numerous aspects behaviour, but their impact enhanced learning remains unexplored. Here we leverage multiple training cohorts demonstrate that higher levels premotor cortical reliably predict individual long-term gains in a new motor task, above beyond initial performance differences. Individual folding-related predisposition was found be independent thickness several intracortical microstructural parameters, dependent larger surface area. We further show learning-relevant features occurred close spatial proximity practice-induced structural plasticity were primarily localized hominoid-specific frontal tertiary sulci. Our results suggest link behavioural adaptability.

Язык: Английский

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Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Опубликована: Окт. 9, 2023

Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) parieto-occipital junction (LPOJ). After defining thousands of sulci a young adult cohort, we four previously unidentified LPC/LOPJ sulci—one which (ventral supralateral occipital sulcus, slocs-v) is present nearly every hemisphere, morphologically, architecturally, functionally dissociable from neighboring regions. A data-driven, model-based approach relating sulcal depth to behavior revealed that morphology only subset LPC/LPOJ including slocs-v, related performance on spatial orientation, but not relational reasoning task. Our findings build classic neuroanatomical theories identify targets for future “precision imaging” studies exploring among brain structure, function, cognitive abilities individual participants.

Язык: Английский

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Lateral frontoparietal functional connectivity based on individual sulcal morphology

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 18, 2024

Abstract A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there mounting evidence that sulcal morphology relevant to functional architecture cognition. However, our understanding relationships between anatomy, activity, behavior still in infancy. We previously found depth three small, shallow sulci lateral prefrontal cortex (LPFC) was linked reasoning performance childhood adolescence (Voorhies et al., 2021). These findings beg question: what linking mechanism cognition? To shed light on this question, we investigated connectivity among LPFC parietal (LPC). leveraged manual parcellations (21 sulci/hemisphere, total 1806) magnetic resonance (fMRI) data from a task 43 participants aged 7–18 years (20 female). conducted clustering classification analyses individual- level sulci. Broadly, 1) patterns individual could be differentiated – more accurately than rotated labels equated for size shape; 2) did not consistently correspond with probabilistic or large-scale networks; 3) clustered together into groups similar patterns, dictated by spatial proximity; 4) across individuals, greater associated higher network centrality several under investigation. results highlight can meaningfully anchored demonstrate vary as function depth. Significance Statement salient, behaviorally relevant, folding. links anatomy are poorly understood particularly shallow, individually variable association cortices. Here, focusing defined regions, offer novel, anatomically informed approach defining connectomes. Further, demonstrate, first time, link morphology.

Язык: Английский

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Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 6, 2023

Recent studies identify a surprising coupling between evolutionarily new sulci and the functional organization of human posteromedial cortex (PMC). Yet, no study has compared this modern PMC sulcal patterning humans non-human hominoids. To fill gap in knowledge, we first manually defined 918 120 chimpanzee ( Pan Troglodytes ) hemispheres 1619 144 hemispheres. We uncovered four sulci, quantitatively identified species differences incidence, depth, surface area. Interestingly, some are more common others, chimpanzees. Further, found that prominent marginal ramus cingulate sulcus differs significantly species. Contrary to classic observations, present results reveal anatomy substantially chimpanzees â€" findings which lay foundation for better understanding evolution neuroanatomical-functional neuroanatomical-behavioral relationships highly expanded region cerebral cortex.

Язык: Английский

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Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 9, 2023

Abstract Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) parieto-occipital junction (LPOJ). After defining thousands of sulci a young adult cohort, we revised previous LPC/LPOJ sulcal landscape to include four previously overlooked, small, shallow, variable sulci. One these (ventral supralateral occipital sulcus, slocs-v) is present nearly every hemisphere morphologically, architecturally, functionally dissociable from neighboring A data-driven, model-based approach, relating depth behavior further revealed that morphology only subset including slocs-v, related performance on spatial orientation task. Our findings build classic neuroanatomical theories identify targets for future “precision imaging” studies exploring among brain structure, function, cognitive abilities individual participants.

Язык: Английский

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Individual differences, missing sulci, and nomenclature: A comment on “On presentation of the human cerebral sulci from inside the cerebrum”

Journal of Anatomy, Год журнала: 2023, Номер 243(6), С. 1066 - 1068

Опубликована: Июль 17, 2023

An average hemisphere of the human cerebral cortex contains over 100 individual folds (sulci). Many these sulci have been overlooked by classic and modern atlases neuroimaging tools. These also show prominent differences: They can be broken into variable "complexes" some may not present altogether.

Язык: Английский

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Microstructural pruning in human prefrontal cortex scaffolds its functional reorganization across development

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 30, 2024

Summary Neural representations in occipitotemporal cortex emerge during development response to visual experience with ecological stimulus categories, such as faces or words. While similar category-selective have also been observed the frontal lobe, how they across development, whether current models of brain extend prefrontal cortex, and extent which high-level are anatomically consistent lifespan is unknown. Through a combination functional quantitative MRI scans, we observe previously undescribed cortical folding patterns human-specific inferior whose consistency reveals that childhood for object categories rearrange into stable adulthood patterns. This restructuring was distinct from where adult-like only scale magnitude development. The unique form accompanied by tissue properties: macromolecules pruned adolescence while proliferate temporal cortex. These results suggest lobes undergo developmental trajectories, shows an especially protracted maturational process necessitates late-stage detectable living brain.

Язык: Английский

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An Insight into developmental changes in reasoning skills among Indian Preschoolers: A cross-sectional study using a story-based approach

F1000Research, Год журнала: 2024, Номер 12, С. 446 - 446

Опубликована: Июль 9, 2024

Background: Considering the importance of exploring development reasoning skills during preschool period and suitability using a culturally linguistically relevant story-based approach for same, present research intended to profile in typically developing Indian children between 36 72 months approach. The specific objectives were determine test-retest inter-rater reliability tasks within an existing cognitive-communicative assessment tool use this assess children. Method: Reasoning across explanation, prediction inference domains evaluated its psychometric properties administered 63 attending English medium schools Mangalore. preschoolers equally divided into three age groups. responses obtained groups analyzed quantitatively qualitatively. Results: developed confirmed have good like reliability. comparisons abilities one-way ANOVA suggested increase with period. qualitative analysis further that increasing age, nature changed from content-based based on prior knowledge which was integrated story content. Conclusion: study describes skill task preschoolers. findings provide clinical educational implications foster among preschoolers.

Язык: Английский

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