Life,
Год журнала:
2024,
Номер
14(11), С. 1499 - 1499
Опубликована: Ноя. 17, 2024
Fibromyalgia
is
a
chronic
illness
usually
accompanied
by
long-lasting,
general
pain
throughout
the
body,
often
anxiety,
depression,
fatigue,
and
sleep
disruption.
Meanwhile,
doctors
scientists
have
not
entirely
discovered
detailed
mechanisms;
patients
always
an
exaggerated
sensation
to
pervasive
without
satisfied
medical
service.
Given
lack
of
knowledge
on
its
underlying
mechanism,
current
treatments
aim
provide
and/or
symptom
relief.
The
present
study
aimed
clarify
role
cannabinoid
receptor
1
(CB1)
signaling
in
mouse
fibromyalgia
model.
To
develop
model,
mice
were
subjected
intermittent
cold
stress
(ICS).
Our
results
indicated
that
mechanical
(2.09
±
0.09
g)
thermal
hyperalgesia
(4.77
0.29
s),
which
evaluated
von
Frey
Hargraves’
tests,
induced
ICS,
suggesting
successful
modeling.
hurting
replies
then
provoked
electroacupuncture
(EA)
but
for
sham
EA
mice.
Further,
Western
blot
analysis,
we
found
significantly
decreased
CB1
protein
levels
thalamus,
somatosensory
cortex,
anterior
cingulate
cortex.
In
addition,
pain-related
kinases
transcription
factor
increased.
Treatment
with
reliably
increased
expression
various
brain
regions
sequentially
alleviated
nociceptive
mediators.
Furthermore,
administration
agonist
attenuated
pain,
reversed
analgesia
antagonist,
further
chemogenetic
inhibition
SSC.
innovative
findings
evidence
interaction
fibromyalgia,
potential
clinical
trials
as
treatment
target.
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Май 10, 2024
In
modern
times
there
is
increasing
acceptance
that
music-based
interventions
are
useful
aids
in
the
clinical
treatment
of
a
range
neurological
and
psychiatric
conditions,
including
helping
to
reduce
perception
pain.
Indeed,
belief
music,
whether
listening
or
performing,
can
alter
human
pain
experiences
has
long
history,
dating
back
ancient
Greeks,
its
potential
healing
properties
have
been
appreciated
by
indigenous
cultures
around
world.
The
subjective
experience
acute
chronic
complex,
influenced
many
intersecting
physiological
psychological
factors,
it
therefore
be
expected
impact
music
therapy
on
may
vary
from
one
situation
another,
person
another.
Where
persists
becomes
chronic,
aberrant
central
processing
key
feature
associated
with
ongoing
experience.
Nonetheless,
beneficial
effects
exposure
relief
reported
across
wide
shown
effective
neonates,
children
adults.
this
comprehensive
review
we
examine
various
neurochemical,
factors
underpin
experience,
potentially
operate
at
levels
–
periphery,
spinal
cord,
brainstem,
limbic
system
multiple
areas
cerebral
cortex.
We
discuss
extent
which
these
individually
combination,
influence
how
affects
both
quality
intensity
pain,
noting
remains
controversy
about
respective
roles
diverse
peripheral
processes
play
Better
understanding
mechanisms
underlie
music’s
together
insights
into
should
aid
developing
more
synergistic
approaches
when
combined
treatments.
ubiquitous
nature
also
facilitates
application
therapeutic
environment
daily
life,
for
individual
social
benefit.
Alcohol Clinical and Experimental Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Abstract
Background
Pituitary
adenylate
cyclase‐activating
polypeptide
(PACAP)
has
been
found
to
be
involved
in
a
wide
range
of
motivated
and
affective
behaviors.
While
the
PACAP‐38
isoform
is
more
densely
expressed
than
PACAP‐27
most
brain,
highly
rodent
paraventricular
nucleus
thalamus
(PVT),
where
females
also
have
greater
expression
males.
Notably,
role
cells
PVT
not
explored.
Methods
Adult,
female
Long‐Evans
rats
were
injected
with
an
adeno‐associated
virus
(AAV)
increase
PACAP
or
control
AAV.
They
then
investigated
for
subsequent
ethanol
drinking
preference;
sucrose
locomotor
activity
novel
chamber,
behavior
light–dark
box,
novelty
suppression
feeding
test,
familiar
forced
swim
test.
Results
Injection
AAV
resulted
specific
levels
PACAP‐27.
Rats
demonstrated
reduced
preference
under
intermittent‐access
procedure
compared
those
In
contrast,
showed
no
significant
difference
sucrose,
any
tested,
except
that
they
spent
less
time
swimming
Conclusions
light
low
overall
level
ability
drinking,
minimal
effects
on
other
behaviors,
supports
idea
compounds
related
should
as
potential
therapeutics
treatment
alcohol
use
disorder.
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 31, 2025
Depression
and
comorbid
pain
are
frequently
encountered
clinically,
the
comorbidity
complicates
overall
medical
management.
However,
mechanism
whereby
depression
triggers
development
of
needs
to
be
further
elucidated.
Here,
by
using
chronic
restraint
stress
(CRS)
mouse
model
pain,
we
showed
that
CRS
hyperactivated
glutamatergic
neurons
in
anterior
cingulate
cortex
(ACC),
as
well
increasing
dendrite
complexity
number.
Chemogenetic
activation
these
can
induce
while
chemogenetic
blockade
reverse
such
depression-induced
pain.
Moreover,
utilized
translating
ribosome
affinity
purification
(TRAP)
combination
with
c-Fos-tTA
strategy
pharmacological
approaches
identified
SIGMAR1
a
potential
therapeutic
molecular
target.
These
results
revealed
previously
unknown
neural
for
provided
new
mechanistic
insights
into
antidepressive
analgesic
effects
disease.
Diseases,
Год журнала:
2025,
Номер
13(4), С. 105 - 105
Опубликована: Март 31, 2025
Aim:
The
aim
of
this
study
is
to
assess
the
prevalence
depressive
disorders
in
patients
with
pelvic
fractures
treated
surgically
at
our
center
years
2017–2022.
Materials
and
Methods:
included
75
patients,
57
men
18
women,
operated
on
2017–2022
due
acetabular
fracture
ring
injury.
Factors
such
as
age,
gender,
chronic
pain
measured
VAS
scale,
incidence
suicidal
thoughts
were
also
analyzed.
participants
completed
Beck
Depression
Inventory
(BDI).
Results:
Thirty-five
out
seventy-five
showed
symptoms
depression
(BDI
score
>
11),
which
47%,
an
average
29
(p
<
0.0001).
Women
obtained
BDI
23,
corresponds
moderate
Beck’s
scale
0.008).
correlation
between
trauma
has
been
found
be
positive
0.0003;
r
=
0.4094).
Furthermore,
women
studied
population
reported
more
often
than
(44%
vs.
14%;
p
0.01).
No
statistically
significant
was
occurrence
length
hospital
stay
patient’s
age
0.5
0.06,
respectively).
Conclusions:
determined
47%.
The
psychological
symptoms
of
temporomandibular
joint
(TMJ)
ankylosis
were
similar
to
that
depressive
disorder,
but
there
no
relevant
evidences
confirm
the
humans
or
animals
with
TMJ
had
disorder.
aim
this
study
was
investigate
association
between
and
disorder
in
rat
model.
Thirty
3-week-old
male
Sprague-Dawley
(SD)
rats
used
study.
damage
complexes
narrowed
space
performed
unilateral
test
group
induce
bony
(experimental
side).
other
underwent
a
sham
operation
(sham
TMJs
control
did
not
undergo
any
operations.
At
8
weeks
postoperatively,
behavioral
tests,
body
weight,
passive
maximum
mouth
opening
(PMMO),
morphological
features
evaluated,
hippocampuses
analyzed
using
western
blotting
immunocytochemistry.
data
compared
by
independent
t-test,
experimental
side
paired
t-test.
correlations
PMMO/area
fusion
duration
immobility,
sucrose
preference,
CB1
receptor
protein,
mean
optical
density
number
BrdU-positive
cell
evaluated
linear
regression
analysis.
level
significance
0.05.
In
group,
traumatic
developed
ankylosis,
area
mass
(21.26
mm2)
larger
than
(1.73
(p
<
0.001).
There
significant
difference
preference
(test
group:
0.36,
0.76,
p
0.001),
immobility
127.36
s,
59.41
weight
156.70
g,
270.06
PMMO
9.98
mm,
28.79
protein
41.00%,
86.69%,
29.60
a.u.,
54.69
2133.71,
4301.95,
negatively
correlated
(r
=
0.953,
while
positively
0.961,
0.955,
0.976,
0.958,
0.001,
all),
0.970,
0.981,
0.971,
all).
present
verified
found
model
ankylosis.
severity
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8636 - 8636
Опубликована: Авг. 8, 2024
Pain
perception
is
the
consequence
of
a
complex
interplay
between
activation
and
inhibition.
Noradrenergic
pain
modulation
inhibits
nociceptive
transmission
perception.
The
main
source
norepinephrine
(NE)
in
central
nervous
system
Locus
Coeruleus
(LC),
small
but
cluster
cells
pons.
aim
this
study
to
review
literature
on
LC-NE
inhibitory
system,
its
influence
chronic
pathways
frequent
comorbidities.
research
showed
that
environmental
processing
modulated
by
system.
If
perpetuated
time,
inputs
can
generate
neuroplastic
changes
reduce
effects
facilitate
development
comorbidities,
such
as
anxiety,
depression
or
sleeping
disturbances.
exact
mechanisms
involved
LC
functional
shift
remain
unknown,
there
some
evidence
they
occur
through
plastic
medial
lateral
their
brain
projections.
Additionally,
are
other
influencing
factors,
like
developmental
issues,
neuroinflammatory
glial
changes,
NE
receptor
affinity
neuronal
firing
rates.
