Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences

Nature Neuroscience, Год журнала: 2023, Номер 26(10), С. 1791 - 1804

Опубликована: Сен. 4, 2023

Язык: Английский

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Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain

Perspectives on Psychological Science, Год журнала: 2023, Номер 19(1), С. 103 - 125

Опубликована: Июнь 30, 2023

The multiple-memory-systems framework-that distinct types of memory are supported by brain systems-has guided learning and research for decades. However, recent work challenges the one-to-one mapping between structures central to this taxonomy, with key memory-related supporting multiple functions across substructures. Here we integrate cross-species findings in hippocampus, striatum, amygdala propose an updated framework subsystems (MMSS). We provide evidence two organizational principles MMSS theory: First, opposing representations colocated same structures; second, parallel structures. discuss why burgeoning has potential a useful revision classic theories long-term memory, what is needed further validate framework, how novel perspective on organization may guide future research.

Язык: Английский

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Making habits measurable beyond what they are not: A focus on associative dual-process models

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 142, С. 104869 - 104869

Опубликована: Сен. 13, 2022

Язык: Английский

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Stimulus control of habits: Evidence for both stimulus specificity and devaluation insensitivity in a dual‐response task

Journal of the Experimental Analysis of Behavior, Год журнала: 2023, Номер 121(1), С. 52 - 61

Опубликована: Дек. 15, 2023

Abstract Goal‐directed and habitual actions are clearly defined by their associative relations. Whereas goal‐directed control can be confirmed via tests of outcome devaluation contingency‐degradation sensitivity, a comparable criterion for positively detecting habits has not been established. To confirm responding, test the stimulus–response association is required while also ruling out control. Here we describe an approach to developing such in rats using two discriminative stimuli that set occasion different responses then earn same outcome. Performance was insensitive showed specificity, indicative stimulus‐controlled behavior. The reliance associations further supported lack sensitivity during single extinction session used here. These results demonstrate concurrently trained come under when they share common By reducing ability one stimulus signal its corresponding response–outcome association, found evidence dissociated from habits. Overall, these experiments provide assessing specific investigate

Язык: Английский

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Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Behavioral flexibility allows animals to adjust actions changing environments. While the basal ganglia are critical for adaptation, specific role of external globus pallidus (GPe) is unclear. This study examined contributions two major GPe cell types-prototypic neurons projecting subthalamic nucleus (Proto GPe→STN neurons) and astrocytes-to behavioral flexibility. Using longitudinal operant conditioning with context reversals, we found that Proto dynamically represent contextual information correlating optimality. In contrast, astrocytes exhibited gradual encoding independent performance. Deleting impaired adaptive responses action-outcome contingencies without altering initial reward-seeking acquisition, highlighting their in enabling Furthermore, discovered integrate inhibitory striatal excitatory inputs, modulating downstream circuits support flexible behavior. research elucidates complementary roles cellular mechanisms

Язык: Английский

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Emotion in action: When emotions meet motor circuits

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105475 - 105475

Опубликована: Ноя. 22, 2023

The brain is a remarkably complex organ responsible for wide range of functions, including the modulation emotional states and movement. Neuronal circuits are believed to play crucial role in integrating sensory, cognitive, information ultimately guide motor behavior. Over years, numerous studies employing diverse techniques such as electrophysiology, imaging, optogenetics have revealed network neural involved regulation or processes. Emotions can exert substantial influence on performance, encompassing both everyday activities pathological conditions. aim this review explore how shape movements by connecting processing circuits. We first provide comprehensive overview impact different control humans rodents. In line with behavioral studies, we set out identify emotion-related structures capable modulating output, behaviorally anatomically. extensively connected system. These drive behavior, essential survival, but also continuously ongoing summary, investigation intricate relationship between emotion movement offers valuable insights into human opportunities enhance holds promise improving mental physical health. This integrates findings from multiple scientific approaches, anatomical tracing, circuit-based dissection, conducted animal subjects. By incorporating these methodologies, present current understanding physiological

Язык: Английский

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Habit and persistence

Journal of the Experimental Analysis of Behavior, Год журнала: 2023, Номер 121(1), С. 88 - 96

Опубликована: Дек. 27, 2023

Abstract Voluntary behaviors (operants) can come in two varieties: Goal‐directed actions, which are emitted based on the remembered value of reinforcer, and habits, evoked by antecedent cues performed without reinforcer's active memory. The perhaps most clearly distinguished with reinforcer‐devaluation test: actions suppressed when reinforcer is separately devalued responding tested extinction, habitual not. But what function habit learning? Habits often thought to be strong unusually persistent. present selective review examines this idea asking whether habits identified test more resistant effects other contingency change, vulnerable relapse, weakening context or permanently place once they learned. Surprisingly little evidence supports that permanent context‐specific than goal‐directed are. Methods make behavior persistent do not necessarily work encouraging habit. learning may a but it automatic efficient particular context.

Язык: Английский

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Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates

iScience, Год журнала: 2022, Номер 26(1), С. 105818 - 105818

Опубликована: Дек. 16, 2022

We previously reported the rapid development of habitual behavior in a discrete-trials instrumental task which lever insertion and retraction act as reward-predictive cues delineating sequence execution. Here we asked whether or performance variables reflective skill automaticity might account for male rats. Behavior habit-promoting was compared with two variants lacking sequence-delineating extension retraction. find that is under goal-directed control absence but not their presence, skilled does predict vs. behavior. Neural activity recordings revealed an engagement dorsolateral striatum disengagement dorsomedial during execution task, specifically. Together, these results indicate delineation promote habit differential striatal subregions responding, pattern may reflect cue-elicited behavioral chunking.

Язык: Английский

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Where Actions Meet Outcomes: Medial Prefrontal Cortex, Central Thalamus, and the Basal Ganglia

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Июль 5, 2022

Medial prefrontal cortex (mPFC) interacts with distributed networks that give rise to goal-directed behavior through afferent and efferent connections multiple thalamic nuclei recurrent basal ganglia-thalamocortical circuits. Recent studies have revealed individual roles for different nuclei: mediodorsal (MD) regulation of signaling properties in mPFC neurons, intralaminar control cortico-basal ganglia networks, ventral medial facilitation integrative motor function, hippocampal functions supported by midline anterior nuclei. Large scale mapping identified functionally distinct subnetworks provide a structural basis understanding information processing functional heterogeneity within the ganglia. Behavioral analyses comparing deficits produced lesions or inactivation specific subregions elucidated interdependent these areas adaptive behavior. Electrophysiological recordings neurons rats performing delayed non-matching-to position (DNMTP) other complex decision making tasks populations activity related actions outcomes underlie behaviors. These include responses preparation, instrumental actions, movement, anticipation delivery action outcomes, memory delay, spatial context. Comparison results mPFC, MD, pallidum (VP) suggest critical prospective processes precede MD reinforcing task-relevant VP providing feedback about outcomes. Synthesis electrophysiological behavioral indicates connecting thalamus are organized support allow organisms act efficiently obtain intended

Язык: Английский

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Habit formation viewed as structural change in the behavioral network

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Апрель 4, 2023

Abstract Habit formation is a process in which an action becomes involuntary. While goal-directed behavior driven by its consequences, habits are elicited situation rather than consequences. Existing theories have proposed that actions controlled corresponding two distinct systems. Although canonical based on such distinctions starting to be challenged, there few theoretical frameworks implement and within single system. Here, we propose novel framework hypothesizing network composed of several responses. With this framework, shown the transition caused change structure. Furthermore, confirmed model behaves manner consistent with existing experimental results reported animal behavioral studies. Our revealed habit could formed under control system By capturing as change, provides new perspective studying structure for research.

Язык: Английский

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