Walking humans and running mice: perception and neural encoding of optic flow during self-motion DOI Creative Commons
Edward A. B. Horrocks, Isabelle Mareschal, Aman B. Saleem

и другие.

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2022, Номер 378(1869)

Опубликована: Дек. 13, 2022

Locomotion produces full-field optic flow that often dominates the visual motion inputs to an observer. The perception of is in turn important for animals guide their heading and interact with moving objects. Understanding how locomotion influences processing therefore essential understand successfully environment. Here, we review research investigating neural encoding are altered during self-motion, focusing on locomotion. Self-motion has been found influence estimation sensitivity speed direction. Nonvisual self-motion signals also increase compensation self-driven when parsing integration nonvisual largely follows principles Bayesian inference can improve precision accuracy perception. calibration dynamic, reflecting changing visuomotor contingencies across different environmental contexts. Throughout this review, consider experimental using humans, non-human primates mice. We highlight challenges opportunities afforded by each these species draw parallels between findings. These findings reveal a profound species. This article part discussion meeting issue 'New approaches 3D vision'.

Язык: Английский

Behavioral origin of sound-evoked activity in mouse visual cortex DOI Creative Commons
Célian Bimbard, Timothy Sit, Anna Lebedeva

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(2), С. 251 - 258

Опубликована: Янв. 9, 2023

Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to multisensory. For instance, primary visual cortex (V1) is influenced not only images but also sounds. Here we show that the activity evoked sounds in V1, measured with Neuropixels probes, stereotyped across neurons even mice. It independent projections from auditory resembles hippocampal formation, which receives little direct input. Its low-dimensional nature starkly contrasts high-dimensional code V1 uses represent images. Furthermore, this sound-evoked precisely predicted small body movements elicited each sound trials Thus, neural apparently multisensory may simply arise signals associated internal state behavior.

Язык: Английский

Процитировано

87
Triple dissociation of visual, auditory and motor processing in mouse primary visual cortex DOI
Matthijs N. Oude Lohuis, Pietro Marchesi, Umberto Olcese

и другие.

Nature Neuroscience, Год журнала: 2024, Номер 27(4), С. 758 - 771

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

18
Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics DOI Creative Commons
Thomas Vaissière,

Sheldon D. Michaelson,

Thomas K. Creson

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 18, 2025

Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice expression of the autism/intellectual disability gene, Syngap1, cortical excitatory neurons is formation somatomotor networks promote SMI-mediated perception. Cortical Syngap1 was necessary and sufficient setting tactile sensitivity, sustaining object exploration, promoting learning. Mice with deficient exhibited impaired neural dynamics induced by exploratory touches within cortical-thalamic network promotes attention Disrupted neuronal were associated circuit-specific long-range synaptic connectivity abnormalities. Our data support model where autonomous abilities assembly circuits integrate temporally-overlapping sensory motor signals, process attention. These provide systems-level insights into robust association between ability.

Язык: Английский

Процитировано

2
Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition DOI Creative Commons
Xiao‐Jing Wang

Annual Review of Neuroscience, Год журнала: 2022, Номер 45(1), С. 533 - 560

Опубликована: Июль 8, 2022

The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable rigorous research. Here, I review recent experimental theoretical on the modus operandi of multiregional cortex. These studies revealed several general principles for neocortical interareal connectivity, low-dimensional macroscopic gradients biological properties across cortical areas, hierarchy timescales information processing. Theoretical suggests testable predictions regarding differential excitation inhibition along feedforward feedback pathways in hierarchy. Furthermore, modeling distributed working memory simple decision-making given rise novel mathematical concept, dubbed bifurcation space, that potentially explains how different canonical circuit organization but heterogeneities, are able their respective (e.g., sensory coding versus executive control) functions modularly organized brain.

Язык: Английский

Процитировано

58
Multiregion neuronal activity: the forest and the trees DOI
Timothy A. Machado,

Isaac Kauvar,

Karl Deisseroth

и другие.

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(11), С. 683 - 704

Опубликована: Окт. 3, 2022

Язык: Английский

Процитировано

40
Activity in primate visual cortex is minimally driven by spontaneous movements DOI Creative Commons
Bharath Chandra Talluri, In‐Cheol Kang,

Adam Lazere

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(11), С. 1953 - 1959

Опубликована: Окт. 12, 2023

Organisms process sensory information in the context of their own moving bodies, an idea referred to as embodiment. This is important for developmental neuroscience, robotics and systems neuroscience. The mechanisms supporting embodiment are unknown, but a manifestation could be observation mice brain-wide neuromodulation, including primary visual cortex, driven by task-irrelevant spontaneous body movements. We tested this hypothesis macaque monkeys (Macaca mulatta), primate model human vision, simultaneously recording cortex activity facial also sought direct comparison using analogous approach those used mouse studies. Here we found that (V1, V2 V3/V3A) was associated with animals' movements, modulation largely explained impact movements on retinal image, is, changes input. These results indicate primates minimally may reflect species-specific sensorimotor strategies.

Язык: Английский

Процитировано

39
Separating cognitive and motor processes in the behaving mouse DOI
Munib A. Hasnain, Jaclyn E Birnbaum,

Juan Luis Ugarte Nunez

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

1
Long-term stability of single neuron activity in the motor system DOI
Kristopher T. Jensen,

Naama Kadmon Harpaz,

Ashesh K. Dhawale

и другие.

Nature Neuroscience, Год журнала: 2022, Номер 25(12), С. 1664 - 1674

Опубликована: Ноя. 10, 2022

Язык: Английский

Процитировано

38
A stable, distributed code for cue value in mouse cortex during reward learning DOI Creative Commons
David J. Ottenheimer, Madelyn M. Hjort, Anna J. Bowen

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 24, 2023

The ability to associate reward-predicting stimuli with adaptive behavior is frequently attributed the prefrontal cortex, but stimulus-specificity, spatial distribution, and stability of cue-reward associations are unresolved. We trained head-fixed mice on an olfactory Pavlovian conditioning task measured coding properties individual neurons across space (prefrontal, olfactory, motor cortices) time (multiple days). Neurons encoding cues or licks were most common in respectively. By quantifying responses cue-encoding six varying probabilities reward, we unexpectedly found value all regions sampled, some enrichment cortex. further that cue lick codes preserved days. Our results demonstrate stably encode components learning within a larger gradient properties.

Язык: Английский

Процитировано

22
Not everything, not everywhere, not all at once: a study of brain-wide encoding of movement DOI Open Access

Ziyue Wang,

Susu Chen, Yi Liu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 9, 2023

Abstract Activity related to movement is found throughout sensory and motor regions of the brain. However, it remains unclear how movement-related activity distributed across brain whether systematic differences exist between areas. Here, we analyzed in brain-wide recordings containing more than 50,000 neurons mice performing a decision-making task. Using multiple techniques, from markers deep neural networks, find that signals were pervasive brain, but systematically differed Movement-related was stronger areas closer or periphery. Delineating terms sensory- motor-related components revealed finer scale structures their encodings within We further identified modulation correlates with uninstructed movement. Our work charts out largescale map encoding provides roadmap for dissecting different forms multi-regional circuits.

Язык: Английский

Процитировано

21