A novel approach to the assessment of higher-order rule learning in male mice. DOI
Renee Chasse, Peter A. Perrino, Ruth M McLeod

и другие.

PubMed, Год журнала: 2023, Номер 30(10), С. 271 - 277

Опубликована: Окт. 1, 2023

Historically, the development of valid and reliable methods for assessing higher-order cognitive abilities (e.g., rule learning transfer) has been difficult in rodent models. To date, limited evidence supports existence higher such as generation complex decision-making mice, rats, rabbits. this end, we sought to develop a task that would require mice learn transfer rule. We trained visually discriminate series images (image set, six total) increasing complexity following three stages: (1) visual target, (2) (ignore any new around target), finally (3) apply abstract form comparable but image set. evaluate each stage, measured days (and performance by day) original target at criterion, get back criterion when set were altered introduction distractors (rule learning), overall experienced versus naïve cohorts tested on same transfer). Twenty-seven wild-type male C57 using Bussey-Saksida touchscreen operant conditioning boxes (Lafayette Instruments). Two black-white sets delivered sequentially (counterbalanced order) two identical mice. Results showed all able effectively their initial could recall it >80 d later. also found quickly "rule" : Ignore continue identify embedded more images. The presence was supported because thresholds regained much faster than introduced. On other hand, appeared unable stimuli. This is discrimination curves no better an (naïve) matched cohort Overall results have important implications phenotyping research particularly modeling disorders

Язык: Английский

Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system DOI
Kurt M. Fraser,

Val Collins,

Amy R. Wolff

и другие.

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Neurocircuits for motivation DOI
Garret D. Stuber

Science, Год журнала: 2023, Номер 382(6669), С. 394 - 398

Опубликована: Окт. 26, 2023

The nervous system coordinates various motivated behaviors such as feeding, drinking, and escape to promote survival evolutionary fitness. Although the precise behavioral repertoires required for distinct are diverse, common features approach or avoidance suggest that brain substrates a wide range of behaviors. In this Review, I describe framework by which neural circuits specified some innate drives regulate activity ventral tegmental area (VTA) dopamine neurons reinforce ongoing planned actions fulfill motivational demands. This may explain why signaling from VTA is ubiquitously involved in many types diverse volitional actions, well how sensory interoceptive cues can initiate specific goal-directed actions.

Язык: Английский

Процитировано

21
Widespread coding of navigational variables in prefrontal cortex DOI
David J.-N. Maisson, Roberto Lopez Cervera, Benjamin Voloh

и другие.

Current Biology, Год журнала: 2023, Номер 33(16), С. 3478 - 3488.e3

Опубликована: Авг. 1, 2023

Язык: Английский

Процитировано

17
A persistent prefrontal reference frame across time and task rules DOI Creative Commons
Hannah Muysers, Hung-Ling Chen, Johannes Hahn

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 8, 2024

Abstract Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons the medial prefrontal cortex (mPFC) mice that reliably maintains trajectory-specific tuning several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame stabilized during learning, upon which repeatedly show little representational drift and maintain their across long pauses exposure repeated changes cue-target location pairings. These data thus suggest ‘core ensemble’ forming task-relevant space for performance consistent behavior periods time.

Язык: Английский

Процитировано

8
Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex DOI Creative Commons
Noel Federman, Sebastián A. Romano, Macarena Amigo-Duran

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 2, 2024

Olfaction is influenced by contextual factors, past experiences, and the animal's internal state. Whether this information integrated at initial stages of cortical odour processing not known, nor how these signals may influence encoding. Here we revealed multiple diverse non-olfactory responses in primary olfactory (piriform) cortex (PCx), which dynamically enhance PCx discrimination according to behavioural demands. We performed recordings neurons from mice trained a virtual reality task associate odours with visual contexts obtain reward. found that learning shifts activity encoding solely regime positional, contextual, associative emerge on odour-responsive become mixed-selective. The modulation was dynamic, improving decoding during engagement rewarded contexts. This improvement relied acquired mixed-selectivity, demonstrating integrating extra-sensory inputs sensory cortices can while relevance stimuli.

Язык: Английский

Процитировано

6
An opponent striatal circuit for distributional reinforcement learning DOI Creative Commons
Adam S. Lowet, Zheng Qiao, Melissa Meng

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 3, 2024

Abstract Machine learning research has achieved large performance gains on a wide range of tasks by expanding the target from mean rewards to entire probability distributions — an approach known as distributional reinforcement (RL) 1 . The mesolimbic dopamine system is thought underlie RL in mammalian brain updating representation value striatum 2,3 , but little about whether, where, and how neurons this circuit encode information higher-order moments reward 4 To fill gap, we used high-density probes (Neuropixels) acutely record striatal activity well-trained, water-restricted mice performing classical conditioning task which mean, variance, stimulus identity were independently manipulated. In contrast traditional accounts, found robust evidence for abstract encoding variance striatum. Remarkably, chronic ablation inputs disorganized these representations without interfering with coding. Two-photon calcium imaging optogenetics revealed that two major classes medium spiny D1 D2 MSNs contributed code preferentially right left tails distribution, respectively. We synthesize findings into new model harnesses opponency between 5–15 reap computational benefits RL.

Язык: Английский

Процитировано

6
Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells DOI Creative Commons
Sander Lindeman, Xiaochen Fu, Janine Kristin Reinert

и другие.

PLoS Biology, Год журнала: 2024, Номер 22(3), С. e3002536 - e3002536

Опубликована: Март 1, 2024

Associating values to environmental cues is a critical aspect of learning from experiences, allowing animals predict and maximise future rewards. Value-related signals in the brain were once considered property higher sensory regions, but their wide distribution across many regions increasingly recognised. Here, we investigate how reward-related begin be incorporated, mechanistically, at earliest stage olfactory processing, namely, bulb. In head-fixed mice performing Go/No-Go discrimination closely related mixtures, rewarded odours evoke widespread inhibition one class output neurons, that is, mitral cells not tufted cells. The temporal characteristics this suggest it odour-driven, also context-dependent since absent during pseudo-conditioning pharmacological silencing piriform cortex. Further, modulation present somata apical dendritic tuft cells, suggesting an involvement circuit components located deep Depth-resolved imaging granule cell gemmules suggests target receive extrinsic drive. Thus, our study supports notion value-related characteristic processing primary area narrows down possible underlying mechanisms deeper contact perisomatically.

Язык: Английский

Процитировано

5
Deep-brain optical recording of neural dynamics during behavior DOI Creative Commons
Zhe Zhou, Adam Gordon-Fennell, Sean C. Piantadosi

и другие.

Neuron, Год журнала: 2023, Номер 111(23), С. 3716 - 3738

Опубликована: Окт. 6, 2023

Язык: Английский

Процитировано

13
Microprisms enable enhanced throughput and resolution for longitudinal tracking of neuronal ensembles in deep brain structures DOI Creative Commons
Madelyn M. Hjort, Raajaram Gowrishankar, Lucy Tian

и другие.

Neurophotonics, Год журнала: 2024, Номер 11(03)

Опубликована: Март 20, 2024

SignificanceMicroprism-mediated calcium imaging of deep brain structures allows for reliable tracking thousands cells across days, a marked improvement compared with industry-standard approaches utilizing gradient-index (GRIN) lenses.AimWe aim to develop method record, track, and functionally characterize cortical subcortical neurons using an endoscopic microprism benchmark the performance against traditional GRIN lenses.ApproachTo improve visualization throughput ensembles, we developed characterized protocol implant microprism. We performed two-photon through microprisms yield, cell quality, optical characteristics lenses.ResultsWe found that our can stably isolate track active days weeks. This high-throughput approach facilitates longitudinal functional characterization large groups neural ensembles in vivo structures. produces high fidelity trackable superior resolution quality higher spatial precision when lenses.ConclusionsThe technique represents significant neuronal ensemble dynamics within tissues.

Язык: Английский

Процитировано

4
An opponent striatal circuit for distributional reinforcement learning DOI
Adam S. Lowet, Zheng Qiao, Melissa Meng

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0