The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents DOI Creative Commons
Takahiro Inoue, Masaki Ueno

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Март 21, 2025

Descending neural pathways to the spinal cord plays vital roles in motor control. They are often damaged by brain injuries such as stroke and trauma, which lead severe impairments. Due limited capacity for regeneration of circuits adult central nervous system, currently no essential treatments available complete recovery. Notably, accumulating evidence shows that residual descending dynamically reorganized after injury contribute Furthermore, recent technological advances cell-type classification manipulation have highlighted structural functional diversity these pathways. Here, we focus on three major pathways, namely, corticospinal tract from cerebral cortex, rubrospinal red nucleus, reticulospinal reticular formation, summarize current knowledge their structures functions, especially rodent models (mice rats). We then review discuss process patterns reorganization induced following injury, compensate lost connections Understanding basic properties each pathway principles induction outcome rewired will provide therapeutic insights enhance interactive rewiring multiple

Язык: Английский

Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation DOI Creative Commons
Susan T. Lubejko, Giulia Livrizzi,

Stanley A. Buczynski

и другие.

Science Advances, Год журнала: 2024, Номер 10(17)

Опубликована: Апрель 26, 2024

The supraspinal descending pain modulatory system (DPMS) shapes perception via monoaminergic modulation of sensory information in the spinal cord. However, role and synaptic mechanisms noradrenergic signaling remain unclear. Here, we establish that neurons locus coeruleus (LC) are essential for opioid antinociception. While much previous work has emphasized serotonergic pathways, find antinociception is primarily driven by excitatory output from ventrolateral periaqueductal gray (vlPAG) to LC. Furthermore, identify a previously unknown opioid-sensitive inhibitory input rostroventromedial medulla (RVM), suppression which disinhibits LC drive We describe pain-related activity throughout this circuit report presence prominent bifurcating outputs vlPAG RVM. Our findings substantially revise current models DPMS antinociceptive pathway may contribute multiple forms modulation.

Язык: Английский

Процитировано

16
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA DOI
Nan Song, Zhenhong Liu, Yan Gao

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер 29(5), С. 1550 - 1566

Опубликована: Фев. 15, 2024

Язык: Английский

Процитировано

11
Endocannabinoids facilitate transitory reward engagement through retrograde gain control DOI Open Access
David J. Marcus,

Anthony E. English,

Ge Chun

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting crucial tuning factor influence neuronal activity by dynamically shaping excitatory and inhibitory fast neurotransmission. The endocannabinoid (eCB) system, the most widely expressed neuromodulatory system in mammalian brain, known filter inputs through retrograde, pre-synaptic action. However, whether eCBs exert retrograde control ultimately facilitate reward-seeking behaviors freely moving mammals not established. Using suite of vivo physiological, imaging, genetic machine learning-based approaches, we report fundamental role controlling behavioral engagement behavior defined thalamo-striatal circuit.

Язык: Английский

Процитировано

1
Effects of chronic ethanol exposure on dorsal medial striatal neurons receiving convergent inputs from the orbitofrontal cortex and basolateral amygdala DOI Creative Commons

Sudarat Nimitvilai‐Roberts,

Marcelo F. Lopez, John J. Woodward

и другие.

Neuropharmacology, Год журнала: 2025, Номер 267, С. 110303 - 110303

Опубликована: Янв. 13, 2025

Язык: Английский

Процитировано

1
The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents DOI Creative Commons
Takahiro Inoue, Masaki Ueno

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Март 21, 2025

Descending neural pathways to the spinal cord plays vital roles in motor control. They are often damaged by brain injuries such as stroke and trauma, which lead severe impairments. Due limited capacity for regeneration of circuits adult central nervous system, currently no essential treatments available complete recovery. Notably, accumulating evidence shows that residual descending dynamically reorganized after injury contribute Furthermore, recent technological advances cell-type classification manipulation have highlighted structural functional diversity these pathways. Here, we focus on three major pathways, namely, corticospinal tract from cerebral cortex, rubrospinal red nucleus, reticulospinal reticular formation, summarize current knowledge their structures functions, especially rodent models (mice rats). We then review discuss process patterns reorganization induced following injury, compensate lost connections Understanding basic properties each pathway principles induction outcome rewired will provide therapeutic insights enhance interactive rewiring multiple

Язык: Английский

Процитировано

1