Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients DOI Creative Commons
Shobi Veleri

Experimental Brain Research, Journal Year: 2021, Volume and Issue: 240(1), P. 9 - 25

Published: Oct. 25, 2021

Language: Английский

Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation DOI Creative Commons
Susan T. Lubejko, Giulia Livrizzi,

Stanley A. Buczynski

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 26, 2024

The supraspinal descending pain modulatory system (DPMS) shapes perception via monoaminergic modulation of sensory information in the spinal cord. However, role and synaptic mechanisms noradrenergic signaling remain unclear. Here, we establish that neurons locus coeruleus (LC) are essential for opioid antinociception. While much previous work has emphasized serotonergic pathways, find antinociception is primarily driven by excitatory output from ventrolateral periaqueductal gray (vlPAG) to LC. Furthermore, identify a previously unknown opioid-sensitive inhibitory input rostroventromedial medulla (RVM), suppression which disinhibits LC drive We describe pain-related activity throughout this circuit report presence prominent bifurcating outputs vlPAG RVM. Our findings substantially revise current models DPMS antinociceptive pathway may contribute multiple forms modulation.

Language: Английский

Citations

14
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA DOI
Nan Song, Zhenhong Liu, Yan Gao

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(5), P. 1550 - 1566

Published: Feb. 15, 2024

Language: Английский

Citations

10
Endocannabinoids facilitate transitory reward engagement through retrograde gain control DOI Open Access
David J. Marcus,

Anthony E. English,

Ge Chun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting crucial tuning factor influence neuronal activity by dynamically shaping excitatory and inhibitory fast neurotransmission. The endocannabinoid (eCB) system, the most widely expressed neuromodulatory system in mammalian brain, known filter inputs through retrograde, pre-synaptic action. However, whether eCBs exert retrograde control ultimately facilitate reward-seeking behaviors freely moving mammals not established. Using suite of vivo physiological, imaging, genetic machine learning-based approaches, we report fundamental role controlling behavioral engagement behavior defined thalamo-striatal circuit.

Language: Английский

Citations

1
Amygdalo-cortical dialogue underlies memory enhancement by emotional association DOI Creative Commons
Yoshihito Saito, Yuma Osako, Maya Odagawa

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients DOI Creative Commons
Shobi Veleri

Experimental Brain Research, Journal Year: 2021, Volume and Issue: 240(1), P. 9 - 25

Published: Oct. 25, 2021

Language: Английский

Citations

55