bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
Age-related
auditory
decline
manifests
across
the
animal
kingdom,
from
humans
and
mice
to
zebrafish
insects.
Sex
differences
in
are
established
for
humans,
but
there
is
now
evidence
even
zebrafish.
Here,
we
found
sex
an
insect,
Desert
Locust
investigated
its
biological
basis.
We
profiled
gene
expression
a
dedicated
organ,
Müller’s
organ
understand
genetic
underpinning
of
measured
sound-evoked
transduction
currents
electrophysiological
properties
neurons
quantify
decline.
analysed
young
locusts
where
were
absent
older,
noise-exposed
maximal.
The
largest
between
sexes
was
stressed
(aged
noise-exposed)
organs.
sex-specific
genes
ontology
terms
juvenile
hormone
(JH)
estrogen-related
steroids.
hypothesise
that
due
hormones
which
then
affect
metabolic
processes
mitochondria.
Highlights
Female
Locusts
have
less
than
males.
Female’s
organs
maintain
better
metabolism
under
conditions.
maximal
during
aging
noise-exposure.
minimal
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 23, 2024
Abstract
Efficacy
of
chemokine
fractalkine
isoforms
was
evaluated
for
restoration
loss
inner
hair
cell
ribbon
synapses
and
hearing
after
noise-induced
cochlear
synaptopathy
(NICS).
Previously,
we
have
demonstrated
a
critical
role
signaling
axis
(CX
3
CL1-CX
CR1)
in
synaptic
repair
where
the
presence
receptor
expressed
by
macrophages,
damaged
are
spontaneously
repaired.
Here,
examined
whether
overexpression
ligand
CL1
or
FKN)
form
peptide
is
effective
restoring
lost
NICS.
Remarkably,
single
transtympanic
(TT)
injection
soluble
isoform
FKN
(sFKN)
at
1
day
synaptopathic
noise
trauma
showed
significant
recovery
ABR
thresholds,
peak
I
amplitudes
both
FKN-wildtype
knockout
mice
when
compared
to
injected
with
full
length
membrane-bound
(mFKN).
Mechanistically,
sFKN
treatment
increased
macrophage
numbers
cochlea
absence
those
failed
restore
Furthermore,
attenuated
inflammation
overexposure
without
altering
expression
CX
CR1.
Finally,
detectable
inside
localized
sensory
epithelium
24
hours
TT
injection.
These
data
provide
robust
proof-of-principle
that
local
delivery
an
immune
factor,
NICS
macrophage-dependent
manner
highlights
potential
as
immunotherapy
due
aging.
Summary
Transtympanic
manner.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 20, 2024
Abstract
Age-related
hearing
loss
(ARHL)
is
a
debilitating
disorder
for
millions
worldwide.
While
there
are
multiple
underlying
causes
of
ARHL,
one
common
factor
sensory
hair
cells.
In
mammals,
new
cells
not
produced
postnatally
and
do
regenerate
after
damage,
leading
to
permanent
impairment.
By
contrast,
fish
produce
throughout
life
robustly
these
toxic
insult.
Despite
regenerative
abilities,
zebrafish
show
features
ARHL.
Here,
we
that
aged
both
sexes
exhibited
significant
cell
decreased
proliferation
in
all
inner
ear
epithelia
(saccule,
lagena,
utricle).
Ears
from
had
increased
expression
pro-inflammatory
genes
significantly
more
macrophages
than
ears
young
adult
animals.
Aged
also
fewer
lateral
line
less
animals,
although
still
regenerated
following
damage.
Unlike
zebrafish,
African
turquoise
killifish
(an
emerging
aging
model)
only
showed
the
saccule
males,
but
exhibit
age-related
changes
line.
Our
work
demonstrates
key
auditory
aging,
including
inflammation.
Further,
our
finding
have
yet
retain
capacity,
suggests
decoupling
homeostatic
addition
regeneration
acute
trauma.
Finally,
species-specific
strategies
homeostasis
may
inform
further
comparative
research
on
mechanosensory
systems.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Окт. 30, 2024
Cochlear
ribbon
synapses
between
sensory
inner
hair
cells
(IHCs)
and
spiral
ganglion
neurons
(SGNs)
are
vulnerable
to
rapid
primary
damage
and/or
loss
due
noise
overexposure.
Such
damaged
can
repair
spontaneously
in
mouse
guinea
pig.
However,
the
mechanisms
for
synaptic
unclear.
Previously,
we
have
demonstrated
a
critical
role
fractalkine
signaling
axis
(CX
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
Age-related
auditory
decline
manifests
across
the
animal
kingdom,
from
humans
and
mice
to
zebrafish
insects.
Sex
differences
in
are
established
for
humans,
but
there
is
now
evidence
even
zebrafish.
Here,
we
found
sex
an
insect,
Desert
Locust
investigated
its
biological
basis.
We
profiled
gene
expression
a
dedicated
organ,
Müller’s
organ
understand
genetic
underpinning
of
measured
sound-evoked
transduction
currents
electrophysiological
properties
neurons
quantify
decline.
analysed
young
locusts
where
were
absent
older,
noise-exposed
maximal.
The
largest
between
sexes
was
stressed
(aged
noise-exposed)
organs.
sex-specific
genes
ontology
terms
juvenile
hormone
(JH)
estrogen-related
steroids.
hypothesise
that
due
hormones
which
then
affect
metabolic
processes
mitochondria.
Highlights
Female
Locusts
have
less
than
males.
Female’s
organs
maintain
better
metabolism
under
conditions.
maximal
during
aging
noise-exposure.
minimal
