Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Oct. 30, 2024
Cochlear ribbon synapses between sensory inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are vulnerable to rapid primary damage and/or loss due noise overexposure. Such damaged can repair spontaneously in mouse guinea pig. However, the mechanisms for synaptic unclear. Previously, we have demonstrated a critical role fractalkine signaling axis (CX
Language: Английский
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 14, 2024
Abstract Age-related auditory decline manifests across the animal kingdom, from humans and mice to zebrafish insects. Sex differences in are established for humans, but there is now evidence even zebrafish. Here, we found sex an insect, Desert Locust investigated its biological basis. We profiled gene expression a dedicated organ, Müller’s organ understand genetic underpinning of measured sound-evoked transduction currents electrophysiological properties neurons quantify decline. analysed young locusts where were absent older, noise-exposed maximal. The largest between sexes was stressed (aged noise-exposed) organs. sex-specific genes ontology terms juvenile hormone (JH) estrogen-related steroids. hypothesise that due hormones which then affect metabolic processes mitochondria. Highlights Female Locusts have less than males. Female’s organs maintain better metabolism under conditions. maximal during aging noise-exposure. minimal
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 23, 2024
Abstract Efficacy of chemokine fractalkine isoforms was evaluated for restoration loss inner hair cell ribbon synapses and hearing after noise-induced cochlear synaptopathy (NICS). Previously, we have demonstrated a critical role signaling axis (CX 3 CL1-CX CR1) in synaptic repair where the presence receptor expressed by macrophages, damaged are spontaneously repaired. Here, examined whether overexpression ligand CL1 or FKN) form peptide is effective restoring lost NICS. Remarkably, single transtympanic (TT) injection soluble isoform FKN (sFKN) at 1 day synaptopathic noise trauma showed significant recovery ABR thresholds, peak I amplitudes both FKN-wildtype knockout mice when compared to injected with full length membrane-bound (mFKN). Mechanistically, sFKN treatment increased macrophage numbers cochlea absence those failed restore Furthermore, attenuated inflammation overexposure without altering expression CX CR1. Finally, detectable inside localized sensory epithelium 24 hours TT injection. These data provide robust proof-of-principle that local delivery an immune factor, NICS macrophage-dependent manner highlights potential as immunotherapy due aging. Summary Transtympanic manner.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 20, 2024
Abstract Age-related hearing loss (ARHL) is a debilitating disorder for millions worldwide. While there are multiple underlying causes of ARHL, one common factor sensory hair cells. In mammals, new cells not produced postnatally and do regenerate after damage, leading to permanent impairment. By contrast, fish produce throughout life robustly these toxic insult. Despite regenerative abilities, zebrafish show features ARHL. Here, we that aged both sexes exhibited significant cell decreased proliferation in all inner ear epithelia (saccule, lagena, utricle). Ears from had increased expression pro-inflammatory genes significantly more macrophages than ears young adult animals. Aged also fewer lateral line less animals, although still regenerated following damage. Unlike zebrafish, African turquoise killifish (an emerging aging model) only showed the saccule males, but exhibit age-related changes line. Our work demonstrates key auditory aging, including inflammation. Further, our finding have yet retain capacity, suggests decoupling homeostatic addition regeneration acute trauma. Finally, species-specific strategies homeostasis may inform further comparative research on mechanosensory systems.
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37223 - e37223
Published: Aug. 31, 2024
Language: Английский
Citations
0
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Oct. 30, 2024
Cochlear ribbon synapses between sensory inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are vulnerable to rapid primary damage and/or loss due noise overexposure. Such damaged can repair spontaneously in mouse guinea pig. However, the mechanisms for synaptic unclear. Previously, we have demonstrated a critical role fractalkine signaling axis (CX
Language: Английский
Citations
0