bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 13, 2024
Abstract
Objectives
Normal
sleep
is
crucial
for
brain
health.
Recent
studies
have
reported
robust
associations
between
disturbance
and
various
structural
functional
traits.
However,
the
complex
interplay
health
macro-scale
organization
remains
inconclusive.
In
this
study,
we
aimed
to
uncover
links
imaging
features
diverse
health-related
characteristics
by
means
of
Machine
Learning
(ML).
Methods
We
used
28,088
participants
from
UK
Biobank
calculate
4677
neuroimaging
markers.
Then,
employed
them
predict
self-reported
insomnia
symptoms,
duration,
easiness
getting
up
in
morning,
chronotype,
daily
nap,
daytime
sleepiness,
snoring.
built
seven
different
linear
nonlinear
ML
models
each
characteristic
assess
their
predictability.
Results
performed
an
extensive
analysis
that
involved
more
than
100,000
hours
computing.
observed
relatively
low
performance
predicting
all
(e.g.,
balanced
accuracy
ranging
0.50-0.59).
Across
models,
best
achieved
was
0.59,
using
a
Linear
SVM
morning.
Conclusions
The
capability
multimodal
markers
characteristics,
even
under
optimization
large
population
sample
suggests
relationship
organization.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 15, 2024
Sleep
is
a
modifiable
behavior
that
can
be
targeted
in
interventions
aimed
at
promoting
healthy
aging.
This
study
aims
to
(i)
identify
the
sleep
duration
trend
US
adults;
(ii)
investigate
relationship
between
and
phenotypic
age;
(iii)
explore
role
of
exercise
this
relationship.
Phenotypic
age
as
novel
index
was
calculated
according
biomarkers
collected
from
adults
based
on
National
Health
Nutrition
Examination
Survey
(NHANES).
information
self-reported
by
participants
discerned
through
individual
interviews.
The
principal
analytical
method
employed
weighted
multivariable
linear
regression
modeling,
which
accommodated
for
complex
multi-stage
sampling
design.
potential
non-linear
explored
using
restricted
cubic
spline
(RCS)
model.
Furthermore,
subgroup
analyses
evaluated
effects
sociodemographic
lifestyle
factors
primary
outcomes.
A
total
13,569
were
finally
included
in,
thereby
resulting
population
78,880,615.
An
examination
temporal
trends
revealed
declining
proportion
individuals
with
insufficient
markedly
deficient
time
since
2015-2016
cycle.
Taken
normal
group
reference,
extreme
short
[β
(95%
CI)
0.582
(0.018,
1.146),
p
=
0.044]
long
0.694
(0.186,
1.203),
0.010]
both
positively
associated
fully
adjusted
According
dose-response
age,
benefit
regular
activity,
whereas
more
tended
have
higher
age.
There
an
inverted
U-shaped
durations
represents
important
step
forward
our
understanding
By
shedding
light
topic
providing
practical
recommendations
habits,
researchers
help
live
longer,
healthier,
fulfilling
lives.
BMJ Public Health,
Год журнала:
2024,
Номер
2(1), С. e001000 - e001000
Опубликована: Май 1, 2024
To
explore
the
nuanced
relationship
between
sleep
patterns,
chronotype,
quality
and
influence
of
health
lifestyle
factors
on
cognitive
performance.
This
cross-sectional
analysis
used
ordinary
least
squares
regression
within
UK
Biobank
database,
assessing
26
820
participants
aged
53-86
years,
categorised
into
two
cohorts:
Cohort
1
(10
067
participants,
56%
female;
completed
all
four
tests
Fluid
Intelligence/reasoning,
Pairs
Matching,
Reaction
Time
Prospective
Memory)
2
(16
753
only
assessments
Matching
Time).
Participant's
self-reported
duration,
chronotype
quality.
Cognitive
function
was
assessed
through
standardised
computerised
tests.
The
adjusted
for
demographic
comorbidity
covariates.
performance
scores
were
evaluated
against
parameters
including
sex,
age,
vascular
cardiac
conditions,
diabetes,
alcohol
intake,
smoking
habits
body
mass
index.
highlighted
a
positive
association
normal
duration
(7-9
hours)
in
(β=0.0567,
95%
CI
0.0284
to
0.0851),
while
extended
negatively
impacted
across
both
cohorts
(Cohort
1:
β=-0.188,
-0.2938
-0.0822;
2:
β=-0.2619,
-0.3755
-0.1482).
Chronotype
distinctions,
particularly
intermediate
evening
types,
linked
superior
function.
Gender,
angina,
high
blood
pressure,
intake
emerged
as
significant
influencers.
study
delineates
multifaceted
variables,
determining
outcomes.
These
findings
highlight
vital
role
health.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 7, 2025
It
has
been
demonstrated
that
older
adults'
cognitive
capacities
can
be
improved
with
sleep
duration.
However,
the
relationship
between
overweight,
obesity,
and
decline
remains
a
subject
of
debate.
The
impact
duration
on
performance
in
seniors
body
mass
index
(BMI)
≥
25
kg/m2
is
largely
unknown.
This
makes
it
an
intriguing
to
explore
further.
study
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
(2011-2014)
2,243
participants.
Weighted
multivariate
linear
regression
smooth
curve
fitting
were
employed
investigate
non-linear
relationships.
A
two-part
model
was
determine
threshold
effects.
Additionally,
subgroup
analysis
interaction
tests
conducted.
Results
showed
negative
association
found
scores
fully
adjusted
Consortium
Establish
Registry
for
Alzheimer's
Disease
(CERAD)
test,
Animal
Fluency
test
(AFT),
Digit
Symbol
Substitution
(DSST).
two-piecewise
then
applied
effect
performance.
When
less
than
5
6
h
per
day,
positively
correlated
CERAD
[ß
(95%
CI):
2.11
(1.17,
3.05),
p
<
0.0001],
AFT
[β
0.25
(-0.17,
0.67),
=
0.2376],
DSST
0.49
(-0.57,
1.56),
0.3654].
there
where
reached
three
inflection
points.
In
overweight
obese
adults,
clear
inverted
U-shaped
function,
consistent
results
across
different
subgroups.
Sleep
durations
around
5-6
may
help
prevent
adults
BMI
kg/m2.
The Neuroscientist,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
It
is
a
widely
held
opinion
that
sleep
important
for
human
brain
health.
Here
we
examine
the
evidence
this
view,
focusing
on
normal
variations
in
patterns.
We
discuss
functions
of
and
highlight
paradoxical
implications
theories
seeing
as
an
adaptive
capacity
versus
theory
benefits
clearance
metabolic
waste
from
brain.
also
evaluate
proposition
plays
active
role
consolidation
memories.
Finally,
review
research
possible
effects
chronic
deprivation
find
causal
health
surprisingly
weak
relative
to
amount
attention
science
society.
While
there
are
well-established
associations
between
parameters
aspects
health,
results
generally
not
consistent
across
studies
measures,
it
clear
what
extent
alterations
patterns
represent
symptoms
or
causes.
Especially,
long
(>8
hours)
general
beneficial
long-term
humans
seems
lack
empirical
support.
suggest
directions
future
establish
solid
foundation
knowledge
about
based
longitudinal
with
frequent
sampling,
individual
differences,
more
ecologically
valid
intervention
studies.
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Май 21, 2025
This
study
aims
to
explore
the
relationship
between
sleep
duration
and
Activity
of
Daily
Living
(ADL)
disability
among
older
adults
in
China.
ADL
severely
impacts
quality
life
is
associated
with
various
physical
mental
health
issues.
With
aging
population
China,
burden
increasing.
Data
were
sourced
from
2018
national
follow-up
Chinese
Longitudinal
Healthy
Longevity
Survey
(CLHLS),
including
9,572
participants
aged
65
above.
Sleep
was
assessed
via
self-reported
questionnaire
categorized
into
short
(<7
h),
medium
(7-8
long
(≥9
h).
evaluated
through
Basic
Activities
(BADL)
Instrumental
(IADL).
Logistic
regression
models
used
analyze
disability,
subgroup
analyses
conducted
differences
by
gender
activity.
The
found
a
significant
non-linear
disability.
Compared
7-8
h,
those
over
9
h
had
significantly
higher
risk
BADL
IADL
(OR
=
1.36,
OR
1.35).
Subgroup
indicated
that
this
existed
different
genders,
age,
activity
levels.
For
maintaining
may
be
an
effective
strategy
for
preventing
Both
excessively
are
increased
population.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 19, 2024
Sleep
has
been
shown
to
impact
navigation
ability.
However,
it
remains
unclear
how
different
sleep-related
variables
may
be
independently
associated
with
spatial
performance,
and
as
whether
gender
play
a
role
in
these
associations.
We
used
mobile
video
game
app,
Sea
Hero
Quest
(SHQ),
measure
wayfinding
ability
US-based
participants.
Wayfinding
performance
on
SHQ
correlate
real-world
wayfinding.
Participants
were
asked
report
their
sleep
duration,
quality,
daytime
sleepiness
nap
frequency
duration
typical
night
(n
=
766,
335
men,
431
women,
mean
age
26.5
years,
range
18-59
years).
A
multiple
linear
regression
was
identify
which
self-reported
performance.
Shorter
durations
significantly
worse
men
only.
Other
showed
non-significant
trends
of
association
When
removing
non-typical
sleepers
(<
6
or
>
9
h
night),
the
significant
between
no
longer
present.
These
findings
from
U.S.-based
participants
suggest
that
an
important
contributor
successful
men.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 9, 2023
Abstract
Sleep
has
been
shown
to
impact
navigation
ability.
However,
it
remains
unclear
how
different
sleep-related
variables
may
be
independently
associated
with
spatial
performance,
and
as
whether
gender
play
a
role
in
these
associations.
We
used
mobile
video
game
app,
Sea
Hero
Quest
(SHQ),
measure
wayfinding
ability
US-based
participants.
Wayfinding
performance
on
SHQ
correlate
real-world
wayfinding.
Participants
were
asked
report
their
sleep
duration,
quality,
daytime
sleepiness
nap
frequency
duration
typical
night
(n
=
737,
409
men,
328
women,
mean
age
27.1
years,
range
18-59
years).
A
multivariate
linear
regression
was
identify
which
self-reported
performance.
For
longer
durations
better
no
such
association
found.
While
other
showed
trends
of
none
significantly
our
model.
These
findings
from
younger
U.S.-based
participants
suggest
that
an
important
contributor
successful
men.
