Psychoneuroendocrinology, Год журнала: 2023, Номер 161, С. 106920 - 106920
Опубликована: Дек. 7, 2023
Язык: Английский
Molecular Psychiatry, Год журнала: 2021, Номер 26(6), С. 2299 - 2315
Опубликована: Янв. 11, 2021
Abstract Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to energy deficits and play a key role control of feeding behavior metabolism. Here, we demonstrate chronic unpredictable stress, an animal model depression, decreases spontaneous firing rates, increases irregularity alters properties both male female mice. These changes are associated with enhanced inhibitory synaptic transmission reduced intrinsic neuronal excitability. Chemogenetic inhibition susceptibility subthreshold stress. Conversely, chemogenetic activation completely reverses anhedonic despair behaviors induced by results indicate stress induces maladaptive plasticity, leading hypoactivity subsequently causing behavioral changes. Our findings suggest ARC component neural circuitry involved mediating depression-related increasing activity coule be novel effective treatment for depression.
Язык: Английский
Процитировано
67
Science Advances, Год журнала: 2024, Номер 10(19)
Опубликована: Май 10, 2024
Corticotropin releasing factor (CRF) network in the oval nucleus of bed nuclei stria terminalis (ovBNST) is generally indicated stress, but its role female-biased susceptibility to anxiety unknown. Here, we established a stress paradigm. We found that CRF release ovBNST during showed pattern, and neurons were more prone be hyperexcited female mice both vitro vivo studies. Moreover, optogenetic modulation exchange activation pattern between male could reverse their anxiety. Last, receptor type 1 (CRFR1) mediated CRF-induced excitation expression. Specific knockdown CRFR1 level or overexpression Therefore, identify CRFR1-mediated hyperexcitation encode
Язык: Английский
Процитировано
11
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
11
Frontiers in Neuroendocrinology, Год журнала: 2021, Номер 63, С. 100928 - 100928
Опубликована: Июнь 24, 2021
Язык: Английский
Процитировано
44
Behavioral Sciences, Год журнала: 2022, Номер 12(8), С. 262 - 262
Опубликована: Июль 29, 2022
In modern society, there has been a rising trend of depression and anxiety. This heavily impacts the population's mental health thus contributes significantly to morbidity and, in worst case, suicides. Modern medicine, with many antidepressants anxiolytics at hand, is still unable achieve remission patients. The pathophysiology anxiety only marginally understood, which encouraged researchers focus on neuropeptides, as they are vast group signaling molecules nervous system. Neuropeptides involved regulation physiological functions. Some act neuromodulators often co-released neurotransmitters that allow for reciprocal communication between brain body. Most studied past were antidepressant anxiolytic effects oxytocin, vasopressin or neuropeptide Y S, Substance P. However, recent years, more novel neuropeptides have added list, implications research development new targets, diagnostic elements, even therapies treat depressive disorders. this review, we take close look all currently their related pathways, roles stress adaptation, etiology humans animal models. We will latest information regarding these associated picture potential uses future.
Язык: Английский
Процитировано
39
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 163, С. 105748 - 105748
Опубликована: Июнь 8, 2024
Язык: Английский
Процитировано
9
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111311 - 111311
Опубликована: Июль 24, 2024
Язык: Английский
Процитировано
9
Translational Psychiatry, Год журнала: 2020, Номер 10(1)
Опубликована: Ноя. 11, 2020
Abstract Early-life stress (ELS) leads to stress-related psychopathology in adulthood. Although dysfunction of corticotropin-releasing hormone (CRH) signaling the bed nucleus stria terminalis (BNST) mediates chronic stress-induced maladaptive affective behaviors that are historically associated with mood disorders such as anxiety and depression, it remains unknown whether ELS affects CRH function adult BNST. Here we applied a well-established paradigm (24 h maternal separation (MS) at postnatal day 3) assessed effects on electrophysiology oval BNST (ovBNST) male mouse offspring. increased behaviors, amplified mEPSCs decreased M-currents (a voltage-gated K + current critical for stabilizing membrane potential) ovBNST neurons, suggesting enhanced cellular excitability. Furthermore, numbers PACAP (the pituitary adenylate cyclase-activating polypeptide, an upstream regulator) cells STEP (striatal-enriched protein tyrosine phosphatase, inhibitor) Interestingly, also brain-derived neurotrophic factor (BDNF) expression, indicating neuronal plasticity. These electrophysiological behavioral were reversed by application CRHR1-selective antagonist R121919 into ovBNST, but not when BDNF was co-administered. In addition, neurophysiological neurons mimic abolished PKC antagonism. Together, our findings indicate results long-lasting activation ovBNST. data highlight regulatory role CRHR1 mediating ELS-induced long-term changes.
Язык: Английский
Процитировано
40
Handbook of clinical neurology, Год журнала: 2021, Номер unknown, С. 385 - 402
Опубликована: Янв. 1, 2021
Язык: Английский
Процитировано
37
Neurochemistry International, Год журнала: 2021, Номер 152, С. 105254 - 105254
Опубликована: Дек. 6, 2021
Язык: Английский
Процитировано
34