Similar somatotopy for active and passive digit representation in primary somatosensory cortex

Human Brain Mapping, Год журнала: 2023, Номер 44(9), С. 3568 - 3585

Опубликована: Май 5, 2023

Abstract Scientists traditionally use passive stimulation to examine the organisation of primary somatosensory cortex (SI). However, given close, bidirectional relationship between and motor systems, active paradigms involving free movement may uncover alternative SI representational motifs. Here, we used 7 Tesla functional magnetic resonance imaging compare hallmark features digit representation tasks which were unmatched on task or stimulus properties. The spatial location maps, somatotopic organisation, inter‐digit structure largely consistent tasks, indicating consistency. We also observed some differences. produced higher univariate activity multivariate information content (inter‐digit distances). showed a trend towards greater selectivity for digits versus their neighbours. Our findings highlight that, while gross are invariant, it is important consider contributions representation.

Язык: Английский

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PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Язык: Английский

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Early brain activity: Translations between bedside and laboratory

Progress in Neurobiology, Год журнала: 2022, Номер 213, С. 102268 - 102268

Опубликована: Март 29, 2022

Язык: Английский

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Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus

Current Biology, Год журнала: 2021, Номер 31(24), С. 5501 - 5511.e5

Опубликована: Ноя. 1, 2021

With our eyes closed, we can track a limb's moment-to-moment location in space. If this capacity relied solely on sensory feedback from the limb, would always be step behind because takes time: for execution of rapid and precise movements, such lags are not tolerable. Nervous systems solve problem by computing representations—or internal models—that mimic movements as they happening, with associated neural activity occurring after motor command but before feedback. Research adults indicates that cerebellum is necessary to compute models. What known, however, when—and under what conditions—this computational develops. Here, taking advantage unique kinematic features discrete, spontaneous limb twitches characterize active sleep, captured developmental emergence cerebellar-dependent model. Using rats at postnatal days (P) 12, P16, P20, compared ventral posterior (VP) lateral (VL) thalamic nuclei, both which receive somatosensory input only latter receives cerebellar input. At all ages, twitch-related VP lagged movement, consistent processing; similar was observed VL through P16. no longer movement instead precisely mimicked itself; depended In addition demonstrating models these findings implicate their development calibration through, least, preweanling period.

Язык: Английский

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Activity in developing prefrontal cortex is shaped by sleep and sensory experience

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 6, 2023

In developing rats, behavioral state exerts a profound modulatory influence on neural activity throughout the sensorimotor system, including primary motor cortex (M1). We hypothesized that similar state-dependent modulation occurs in prefrontal cortical areas with which M1 forms functional connections. Here, using 8- and 12-day-old rats cycling freely between sleep wake, we record M1, secondary (M2), medial (mPFC). At both ages all three areas, increased during active (AS) compared wake. Also, regardless of state, periods when limbs were moving. The movement-related M2 mPFC, like is driven by sensory feedback. Our results, diverge from those previous studies anesthetized pups, demonstrate AS-dependent responsivity extend to cortex. These findings expand range possible factors shaping activity-dependent development higher-order areas.

Язык: Английский

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Passive Mapping of Hand Motor Cortex across Altered States of Consciousness

International Journal of Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Апрель 22, 2025

To evaluate the ability of median nerve stimulation (MNS)-induced high gamma band (HGB) activity in mapping hand motor cortex at different states consciousness. Five patients undergoing awake craniotomy were recruited. MNS-induced electrocorticographic signals recorded from to anesthetic states, with loss consciousness (LOC) session divided into three stages (LOC1, LOC2, and LOC3) based on conscious level. HGB analyzed localize cortex. Linear models applied analyze dynamics during LOC. The sensitivity average envelope short-latency period was 100%, 96.67%±3.33%, 83.47%±8.19%, 82.22%±11.44% for awake, LOC1, LOC2 LOC3 stages. long-latency 92.67%±4.52%, 90.85%±4.13%, 72.27%±17.07%, 40.53%±12.82% across same power decreased 100% stage 72.83%±12.95%, 48.11%±15.95%, 21.12%±5.70% LOC dropped 92.67%±4.52% 70.94%±10.79%, 58.37%±17.49%, 25.71%±14.95% subsequent slope coefficient simple linear model significantly smaller than that short-latency. In mixed effects model, Condition × Sliding Window estimate -0.794. state, both effectively localized With declining consciousness, deteriorated, while remained relatively stable.

Язык: Английский

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Investigation of changes in the interaction of cerebral cortex during the oral swallowing task

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111399 - 111399

Опубликована: Май 1, 2025

The main swallowing activities in the oral phase include chewing and tongue movements. Cortical control is essential for initiation coordination of phase. This study aims to further investigate whether there are differences neural mechanisms cortical interactions underlying by simulating movement. recruited 25 healthy adult participants, functional magnetic resonance imaging collect data Empty task Tongue-to-Palate posterior Retraction task. Dynamic causal modelling Parametric Empirical Bayes were used analyze best model effective connectivity between brain regions under different tasks. In Chewing task, primary motor cortex(M1) driving input area with significant excitatory somatosensory cortex(S1) supplementary area(SMA). However, S1 becomes maintains bidirectional connections M1 SMA, but shows an inhibitory effect on SMA. reveals interaction among during activity. Results suggest SMA vital whole a key region while important sensory feedback. may inhibit aid reduce interference pharyngeal action.

Язык: Английский

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Elucidating Development Trajectories of Brain Functional Abnormalities in Major Depressive Disorder Utilizing a Data‐Driven Disease Progression Model

Human Brain Mapping, Год журнала: 2025, Номер 46(8)

Опубликована: Июнь 1, 2025

ABSTRACT Concerns have arisen regarding the heterogeneity of patients with major depressive disorder (MDD), particularly when varying disease progression trajectories among individuals are overlooked. Recognizing these distinct is crucial for personalized assessments and accurate predictions in MDD, posing a significant challenge clinical practice. We utilized data‐driven subtype stage inference (SuStaIn) model to infer based on cross‐sectional amplitude low‐frequency fluctuations (ALFF) derived from resting‐state functional magnetic resonance imaging data 833 MDD 834 healthy controls. Based trajectories, two subtypes were identified: Subtype 1 showed declining ALFF paracentral lobule (PCL) thalamus medial orbitofrontal cortex (OFCmed), higher core depression scores gray matter atrophy, whereas 2 had an opposing trajectory, initial OFCmed decrease gradually extending PCL. Our findings contribute better understanding facilitate precise predictions.

Язык: Английский

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Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Июнь 4, 2025

Язык: Английский

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Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse

Frontiers in Neuroanatomy, Год журнала: 2023, Номер 17

Опубликована: Янв. 25, 2023

The development of functionally interconnected networks between primary (S1), secondary somatosensory (S2), and motor (M1) cortical areas requires coherent neuronal activity via corticocortical projections. However, the anatomical substrate functional connections S1 M1 or S2 during early remains elusive. In present study, we used ex vivo carbocyanine dye (DiI) tracing in paraformaldehyde-fixed newborn mouse brain to investigate axonal projections neurons different layers barrel field (S1Bf), M1, toward subplate (SP), a hub layer for sensory information transfer immature cortex. addition, performed extracellular recordings neocortical slices unravel connectivity these areas. Our experiments demonstrate that already at P0 from plate (CP), 5/6 (L5/6), SP both send through S1Bf. Reciprocally, CP S1Bf S2. Electrophysiological with multi-electrode arrays revealed weak, but synaptic L5/6 within M1. An even lower was observed summary, our findings upper are not confined same area, connection adjacent exist day birth. Hereby, can integrate S1, shape sensorimotor integration an stage.

Язык: Английский

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